[PDF] Top 20 Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.
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Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.
... p53 immunoprecipitations from the rare colonies of cells arising following transfection with pE7 plus ras plus wild-type p53 or Ela plus ras plus wild-type p53 show that the level of p53[r] ... See full document
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p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein
... coat. Expression of these ORFs is controlled by a non-cod- ing Long Control Region (LCR) that contains a complex array of transcription factor binding sites and the viral ori- gin of replication ...and E7 ... See full document
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Identification of the FHL2 Transcriptional Coactivator as a New Functional Target of the E7 Oncoprotein of Human Papillomavirus Type 16
... for human anogenital cancers ...the expression of the E6 and E7 oncoproteins. The E7 oncoprotein of human papillomavirus type 16 (HPV-16) was shown to ... See full document
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Interactions with Pocket Proteins Contribute to the Role of Human Papillomavirus Type 16 E7 in the Papillomavirus Life Cycle
... the properties of rafts harboring the E7 ⌬PTLHE mu- tant HPV16 replicon, in which the differentiation program is unaltered, yet DNA synthesis is induced in the suprabasal compartment ...that E7 ... See full document
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Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation.
... and E7 genes by genetic studies (17, 34, ...HPV type 18 (HPV-18)-positive cervical carcinoma cells (SW756 cells), in which E6 and E7 expression can be con- trolled by glucocorticoids, it was ... See full document
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Compromised Spindle Assembly Checkpoint due to Altered Expression of Ubch10 and Cdc20 in Human Papillomavirus Type 16 E6- and E7-Expressing Keratinocytes
... (26). Human papillomaviruses (HPVs) which cause various epithelial cancers, produce two proteins, E6 and E7, whose expression allows bypass or overriding of normal DNA damage and spindle checkpoint ... See full document
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Human Papillomavirus Type 16 E6/E7 Upregulation of Nucleophosmin Is Important for Proliferation and Inhibition of Differentiation
... and E7 oncoproteins to disrupt the normal process of differentiation of HFKs by targeting key tumor suppressors such as p53 (28) and pRb (17, 37), resulting in increased levels of cell survival proteins ... See full document
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Myc and Human Papillomavirus Type 16 E7 Genes Cooperate To Immortalize Human Keratinocytes
... oncogenic human papillomaviruses (HPVs), in combination with the E7 protein, is essential for the efficient immortalization of human foreskin keratinocytes ...the human telomerase reverse ... See full document
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Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation.
... a p53-independent manner (10). Expression of viral oncogenes simian virus 40 T antigen, adenovirus E1a, and HPV E7 have been shown to overcome TGF- b ...of p53 in differentiating keratinocytes ... See full document
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Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein.
... the E7-expressing clones, consistent with the FACS analysis data, verifying that the cells were continuing to ...in E7-expressing cells. No difference in mRNA levels was seen in the E7-expressing ... See full document
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The Human Papillomavirus Type 16 E7 Oncogene Is Required for the Productive Stage of the Viral Life Cycle
... The expression patterns of two p53-responsive genes, p21 and mdm2, were ...not E7-defective ...of E7 to bind and inactivate ...of E7 in the productive stage of the viral life cycle, ... See full document
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Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Centrosomal Component γ-Tubulin
... persistent expression of viral E6 and E7 oncoproteins, and the deregulated expression of these proteins is necessary for the initiation and mainte- nance of the transformed phenotype (reviewed in ... See full document
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The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19ARF
... MDM2 expression by antisense oligonucleotides resulted in dephosphorylation of pRb and in increased amounts of E2F1 in complexes with pRb in a human tumor cell ...which E7 stimulates the release of ... See full document
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Effects of human papillomavirus (HPV) type 16 oncoproteins on the expression of involucrin in human keratinocytes
... IVL expression by the HPV oncoproteins was caused by inhibiting the transcriptional activity of the IVL ...HPV 16 E6 and/or E7 expression vectors along with luciferase reporter con- structs ... See full document
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Perturbation of the p53 response by human papillomavirus type 16 E7.
... and E7-expressing ...wild-type p53 function ...the E7-expressing cells, indicating that the accumulation is not dependent on cell cycle ...that E7 expression resulted in an ... See full document
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Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene.
... the properties of the HPV-16 E7 oncogene when its expression is directed to the squamous epithelium in transgenic ...mice. E7 was found to efficiently induce epidermal ...of E7 ... See full document
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Peptide Interactions Stabilize and Restructure Human Papillomavirus Type 16 E6 To Interact with p53
... 16E6 expression but fails to tar- get the degradation of ...the p53 core DNA binding domain. (A) Diagram of p53 domains, adapted from ...of p53 domains with LXXLL-bound ...the p53 ... See full document
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A Synthetic E7 Gene of Human Papillomavirus Type 16 That Yields Enhanced Expression of the Protein in Mammalian Cells and Is Useful for DNA Immunization Studies
... HPV-16 E7 gene was engineered in vitro by introducing 64 silent mutations (22% of the E7 sequence), which created an open reading frame consisting entirely of preferred human ...synthetic ... See full document
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The E6 and E7 Proteins of the Cutaneous Human Papillomavirus Type 38 Display Transforming Properties
... as p53 and/or ras) act synergistically in the trans- formation of the host ...biological properties of the viral oncoproteins E6 and ...whose E7 proteins are almost 90% similar to HPV38 E7 and ... See full document
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Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells.
... Each lane was loaded with 200 ,ug of protein lysates from the normal parent cell line 76N, cervical carcinoma cell line Siha, known to contain HPV16 E6 protein 1, transfectants containin[r] ... See full document
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