[PDF] Top 20 Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis
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Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis
... inflammatory arthritis (not med- ically confirmed as RA, but excluding OA) in their fam- ily only on the maternal side (mother, siblings, maternal ...of arthritis (OR = ... See full document
13
Modulation of peripheral T cell function by interleukin 7 in rheumatoid arthritis
... Lack of IL-7 recovery in CR is associated with relapse Importantly, levels of IL-7 in CR were lower in patients who experienced a flare within an 18-month follow-up period (Figure 1B, left panel, P = ... See full document
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Modulation of T cell responses by anti tumor necrosis factor treatments in rheumatoid arthritis: a review
... + T cells, called T peripheral helper (Tph) cells, has been identified in the synovial mem- brane of RA patients using mass cytometry technology ...+ T cells that express high levels of the ... See full document
9
Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia
... To date, IL-7 is not a cytokine that has been associated with RA. However, there are conflicting results regarding its expression in RA patients. In one study [48] IL-7 was present at high levels in the ... See full document
14
Interleukin 7 deficiency in rheumatoid arthritis: consequences for therapy induced lymphopenia
... new T- cells. This was evident not only when comparing naïve T- cell reconstitution in RA and cancer cohorts ...activity, T- cell proliferation and death, and TREC measurements ...and ... See full document
13
Interleukin 7 aggravated joint inflammation and tissue destruction in collagen induced arthritis is associated with T cell and B cell activation
... mainly T-cell activation but can also directly induce proinflammatory activities from several other cell ...RA peripheral blood (PB) and SF produce primarily Th1 and Th17 cytokines [8,12], and ... See full document
9
Different T cells' distribution and activation degree of Th17 CD4+ cells in peripheral blood in patients with osteoarthritis, rheumatoid arthritis, and healthy donors: preliminary results of the MAGENTA CLICAO study
... We analyzed blood samples of 91 subjects (75 females, 16 males): 15 patients with well-defined RA, 56 with hip or knee OA, and 20 healthy age matched controls. Median age was 43 (range 34–52) years old (P.0.05 between ... See full document
6
Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL 1β/TNF
... CD4+ T cells and others ...[14], T cells [12] and fibroblasts ...This peripheral rhythm of fibroblasts can be modulated by systemic factors, such as glucocorticoids ... See full document
12
MicroRNA 146a expresses in interleukin 17 producing T cells in rheumatoid arthritis patients
... TGA T -3′(reverse); RORgt, 5′- TGA GAA GGA CAG GGA GCC AA-3′(forward), 5′- CCA CAG ATT TTG CAA GGG ATC A -3′ (reverse); SOCS1, 5′- GAA CTG CTT TTT CGC CCT TA -3′(for- ward), 5 ′ - CTC GAA GAG GCA GTC GAA G -3 ′ ... See full document
11
T cells in rheumatoid arthritis
... (cytotoxic T-lymphocyte antigen 4) and GITR (glucocorticoid-induced TNF receptor) ...and function remains a topic of great ...and function of Treg subsets, inflammatory cytokines such as IL-7, ... See full document
10
Heterogeneous expression pattern of interleukin 17A (IL 17A), IL 17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti IL 17 therapy?
... USA), T cells (biotin-conjugated mouse anti-CD4: IgG1, clone RPA-T4; Biolegend, San Diego, CA, USA; and biotin-conjugated mouse anti-CD8: IgG1, clone RFT8; SouthernBiotech, Birmingham, AL), B cells ... See full document
10
Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis
... Seropositive rheumatoid arthritis (RA) in adult and juvenile patients is associated with the serologic marker ...biological function of class II molecules is to restrict the recognition of antigen by ... See full document
9
Rheumatoid arthritis patients exhibit impaired Candida albicans specific Th17 responses
... in rheumatoid arthritis. Rheumatoid arthritis (RA) subjects exhibit impaired Candida albicans-specific T-cell responses compared with healthy ...(A) Peripheral blood ... See full document
9
Interleukin-34: Regulator of T Lymphocytes in Rheumatoid Arthritis
... on T and B lymphocytes via PTP- (and syndecan-1), as PTP- protein was detected in T and B lymphocytes in renal biopsies from mice with advanced lupus nephritis ... See full document
5
Original Article Correlation between miRNA-126 expression abnormality and hypo-methylation of DNA in T cells of rheumatoid arthritis patients with respiratory failure
... SLE patients played a role in T cell methylation via mediating DNMT1 expression. Bioin- formatics analysis found that EGFL7 was the host gene of miR-126, between which certain correlation existed. A ... See full document
6
Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis
... of T cell specificities in the synovial fluid of patients has been taken as evidence for a local stimulation of T ...the T cell receptor (TCR) repertoire of CD4+ T cells in the ... See full document
10
Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6
... enabling cell cycle and may sustain proliferation of autoreactive T and B cell ...autoantibodies. Rheumatoid factor, anti-Fc-gamma antibodies, belongs to the canonical autoantibody repertoire ... See full document
15
Targeting interleukin-6 in rheumatoid arthritis
... lack head-to-head success in regards to superiority of the biologics given as monotherapy against methotrexate [3-5]. Even when a TNF-inhibitor is given in combination with DMARDs, the rate of inadequate response has ... See full document
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Original Article CD38 positive natural killer cells may be involved in progression of inflammation in rheumatoid arthritis patients
... Rheumatoid arthritis (RA) is a chronic inflam- matory process of synovial membrane, which induces the destruction of cartilage and ...impaired cell activity in the peripheral blood (PB) in RA ... See full document
9
Ageing, autoimmunity and arthritis: T cell senescence and contraction of T cell repertoire diversity – catalysts of autoimmunity and chronic inflammation
... senescent T cells appears not only to be important in autoimmune disease manifesta- tions but also in more subtle inflammatory reactions that are associated with tissue homeostasis and ...null T cells, ... See full document
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