[PDF] Top 20 <p>A Molecular Epidemiological Analysis Of Programmed Cell Death Ligand-1 (PD-L1) Protein Expression, Mutations And Survival In Non-Small Cell Lung Cancer</p>
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<p>A Molecular Epidemiological Analysis Of Programmed Cell Death Ligand-1 (PD-L1) Protein Expression, Mutations And Survival In Non-Small Cell Lung Cancer</p>
... detects genomic alterations at extremely high coverage in 1053 cancer-related genes spanning a 4.6 Mb region of the genome, including base substitutions, insertions and dele- tions, copy number alterations, and ... See full document
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Original Article High level of programmed death ligand 1 (PD-L1) predicts longer survival in patients with resectable small cell lung cancer
... the expression of programmed cell death ligand 1 (PD-L1) and the survival of patients with small cell lung cancer (SCLC) who had ... See full document
8
Pembrolizumab and salvage chemotherapy in EGFR T790M-positive non-small-cell lung cancer with high PD-L1 expression
... for non-small-cell lung cancer ...(EGFR) mutations than in those with wild-type EGFR. We report here that an non-small-cell lung cancer patient ... See full document
5
Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy
... grammed cell death protein 1 (PD-1). PD-1 is expressed by T cells and interacts with its ligands programmed cell death protein ... See full document
7
PD-1/PD-L1 blockades in non-small-cell lung cancer therapy
... Abstract: Lung cancer is the leading cause of cancer death in males and the second leading cause of death in females ...worldwide. Non-small-cell lung ... See full document
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Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
... by programmed cell death protein-1 ...CTLA-4, PD-1 regulates immune activ- ity when effector T cell tissue infiltration ...cells, PD-1 is mainly ... See full document
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CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
... B; PD-1: Programmed cell death receptor-1; PD-L1: Programmed cell death ligand-1; NSCLC: Non- small-cell ... See full document
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The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody has a good effect in the treatment of ... See full document
6
Consistency of tumor and immune cell programmed cell death ligand-1 expression within and between tumor blocks using the VENTANA SP263 assay
... Resected non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC) and urothelial carcinoma (UC) tissue samples (five samples per tumor type) were ... See full document
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<p>BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes</p>
... BTLA expression and clinical baseline characteristics (eg, age, sex, smoking status, his- tologic type, and stage) was analyzed with the chi-square ...the expression levels of BTLA with PD-1, ... See full document
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Utility of PD-L1 immunohistochemistry assays for predicting PD-1/PD-L1 inhibitor response
... of programmed cell-death receptor (PD-1) and its associated ligand (PD-L1) have gained significant attention from the oncology ...community. PD-L1, ... See full document
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Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer
... the cancer-immunity cycle [19, ...T-lymphocyte protein 4 (CTLA4) and programmed cell death protein-1 (PD-1), are the best ...overall survival of ... See full document
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Intralymphatic histiocytosis in a patient with lung adenocarcinoma treated with pembrolizumab: a case report
... advanced non-small- cell lung cancer (NSCLC) [1, ...anti-programmed death (PD-1) antibody, has shown favorable antitumor efficacy in NSCLC patients ... See full document
5
Stratification of ovarian tumor pathology by expression of programmed cell death-1 (PD-1) and PD-ligand- 1 (PD-L1) in ovarian cancer
... for cancer has been the targeting of immune check- point inhibitory molecules ...and ligand suppresses T cell receptor signaling, and limits immune ...molecule programmed cell ... See full document
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Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer
... have declined significantly in developed countries, how- ever, the mortality is still high in developing countries. Approximately 90% of cervical cancer deaths occurred in low income and middle-income countries ... See full document
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<p>Programmed cell death 1 expression and Epstein-Barr virus infection in chronic lymphocytic leukaemia: a prospective cohort study</p>
... We isolated DNA from 5×10 6 PBMCs with the QIAamp DNA Blood Mini Kit (QIAGEN, Hilden, Germany) according to the manufacturer ’ s instructions. The concen- tration and purity of the isolated DNA were veri fi ed with the ... See full document
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<p>Immunological nomograms predicting prognosis and guiding adjuvant chemotherapy in stage II colorectal cancer</p>
... estimate PD-L1 expression in tumor cells for 168 patients with stage II ...univariate analysis, patients with high intraepithelial or stromal CD3+, CD8+, CD45RO+ and FOXP3+ TILs were ... See full document
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The frequency of high PD-L1 expression is low in lung adenocarcinoma patients from Northeast Brazil
... PD-L1 expression by immunohistochemistry (IHC) has emerged as an important factor, playing a major role in patient ...biomarker, PD-L1 helps to optimize therapy decisions by providing ... See full document
6
Checkpoint molecule PD-1-assisted CD8<sup>+</sup> T lymphocyte count in tumor microenvironment predicts overall survival of patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors
... and non- specific staining with 3% (v/v) hydrogen peroxide and normal goat serum, the sections were incubated with anti-primary antibody overnight at ...anti-human PD-1 (ab52587, Abcam), and rabbit ... See full document
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PD-L1 expression and tumor mutational burden status for prediction of response to chemotherapy and targeted therapy in non-small cell lung cancer
... longer survival in low/moderate TMB plus negative PD-L1 subgroup compared to other two subgroups ...advanced lung cancer showing significant associa- tions between TMB and response to ... See full document
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