[PDF] Top 20 Molecular Evolution: The HIV Envelope Protein
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Molecular Evolution: The HIV Envelope Protein
... The HIV envelope protein (Env) is essential for binding to a human lymphocyte or T ...transmembrane protein called gp41 and a surface protein gp120, which are attached to one another ... See full document
5
Evolution of the HIV 1 envelope glycoproteins with a disulfide bond between gp120 and gp41
... Env protein by the engineered disulfide bond and to identify viruses with potentially interesting second-site reversions, we passaged several virus cultures for a pro- longed period (table 1, cultures ...The ... See full document
11
The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV 2 infected patients
... and evolution and C2V3C3- specific antibody response over ...chronic HIV-1 infec- tions where the virus quickly escapes from anti-V3 and anti-C3 autologous neutralizing antibodies ...of HIV-2 to ... See full document
12
The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses.
... enhance HIV-2 par- ticle release. Such a putative Vpu-like activity of the HIV-2 Env was observed either in the context of the ROD10 mo- lecular clone or when provided in trans to HIV-1/HIV-2 ... See full document
16
Directed Molecular Evolution of an Engineered Gammaretroviral Envelope Protein with Dual Receptor Use Shows Stable Maintenance of Both Receptor Specificities
... The same change was seen in the base pair sequence of F183L in all four studies and results in a transition from a thymine to a cytosine; TTC becomes CTC. This could indicate that the muta- tion might already be present ... See full document
10
Molecular clock of HIV 1 envelope genes under early immune selection
... The HIV-1 gene population within an infected indi- vidual shows heavy selection signatures and fast-paced evolution due to a rapid turn-over rate and high muta- tion ...an HIV-1 population evolves ... See full document
12
RNA structures and their molecular evolution in HIV : evolution of robustness in RNA structures and theoretical systems
... of evolution at individual sites, since base-paired sites are expected to evolve more slowly than non-paired ...of protein-coding into account, places of very strong coding conservation can give a false ... See full document
102
Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV 1
... pNL4-3 molecular clone [catalog # 114, GenBank: AF324493] was obtained from the NIH AIDS Research & Reference Reagent ...way: HIV-1pNL4-3 was amplified by PCR with primers containing the XhoI and XbaI ... See full document
15
Adaptive Evolution of the SIV Envelope Protein During Early SIV Infection
... Most HIV and SIV gp120 subunits have an average of 24 N-linked glycosylation sites (NLGS) and an average of 3 NLGS in the ectodomain of ...from HIV-1 infected patients and SIV-infected rhesus macaques often ... See full document
186
Molecular Evolution: HIV Drug Targets and Resistance
... the envelope protein with CD4 and a coreceptor, the host and virus membranes fuse and the HIV core, called the matrix/capsid, containing its RNA genome and related proteins enter the ... See full document
5
Cell- and Protein-Directed Glycosylation of Native Cleaved HIV-1 Envelope
... In this study, we used ion mobility mass spectrometry (MS), negative-ion collision-induced dissociation (CID), and high-per- formance liquid chromatography (HPLC) (24–26) to compare, in detail, the glycan structures ... See full document
13
HIV 1 envelope, integrins and co receptor use in mucosal transmission of HIV
... In general the neutralizing antibody responses to HIV-1 in vivo are of limited breadth [92]. This is particularly true for the V1/V2 loop. Autologous neutralizing anti- bodies against V1/V2 are frequently detected ... See full document
10
Isolation and partial characterization of an unusual human immunodeficiency retrovirus from two persons of west-central African origin.
... Although the protein profile of ANT 70 was similar to those of HIV-1 and HIV-2, reproducible molecular weight differences were particularly evident for the major viral core protein, whic[r] ... See full document
10
Molecular evolution of HIV 1 integrase during the 20 years prior to the first approval of integrase inhibitors
... a very small phylogenetic distance and replaced them with one representative sequence (the sequence from the patient who was diagnosed first). For clustering, a multiple sequence alignment (MSA) including an HIV-1 ... See full document
13
Generation of Mucosal Anti-Human Immunodeficiency Virus Type 1 T-Cell Responses by Recombinant Mycobacterium smegmatis▿
... insert HIV-1 envelope (env) CON6-gp120 or CON6-gp140CF gene ...the HIV-1 CON6 env gene in the pMV261 and pMV361 vectors is regulated by the Mycobacterium tuberculosis heat shock protein 60 ... See full document
8
Different requirements for membrane fusion mediated by the envelopes of human immunodeficiency virus types 1 and 2.
... CD4independent fusion was not observed for the HIV-1 envelope or in cell lines permissive for CD4-dependent fusion mediated by the HIV-2 envelope, such as HeLa or U87MG cells 8, and prob[r] ... See full document
5
Molecular evolution of herpesviruses: genomic and protein sequence comparisons.
... We propose a measure of dinucleotide distance between two sequences f and g e.g., sequences from different organisms or from different regions of a genomic sequence, which controls for d[r] ... See full document
17
Mediation of human immunodeficiency virus type 1 binding by interaction of cell surface heparan sulfate proteoglycans with the V3 region of envelope gp120-gp41.
... the envelope protein, 13H8 and ...the envelope protein (F105 and 1B1), the anti-V2 domain MAb 6E10, and the anti-gp41 MAb ...the envelope and ... See full document
7
Inhibition of Murine Leukemia Virus Envelope Protein (Env) Processing by Intracellular Expression of the Env N-Terminal Heptad Repeat Region
... fluorescent protein (YFP) in plasmid YFP-GL-GPI (22), to generate plasmid NH-YFPgpi ...MLV envelope protein by ligating a 5 ⬘ -end-phosphorylated oli- gonucleotide adapter (sense strand, 5⬘ ... See full document
11
Recruitment of the Adaptor Protein 2 Complex by the Human Immunodeficiency Virus Type 2 Envelope Protein Is Necessary for High Levels of Virus Release
... the HIV-2 Env defined two func- tional domains in the protein that are required for EVR ac- tivity, a conserved GYxx motif in the membrane-proximal part of the cytoplasmic tail (GYPRV) and an unidentified ... See full document
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