[PDF] Top 20 Foot-and-Mouth Disease Virus Nonstructural Protein 2C Interacts with Beclin1, Modulating Virus Replication
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Foot-and-Mouth Disease Virus Nonstructural Protein 2C Interacts with Beclin1, Modulating Virus Replication
... Foot-and-mouth disease virus (FMDV), the causative agent of foot-and-mouth disease, is an Apthovirus within the Picornaviri- dae ...family. Replication of the ... See full document
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Molecular Characterization of the Viroporin Function of Foot-and-Mouth Disease Virus Nonstructural Protein 2B
... Infectious virus was rescued from cells transfected using the construct pO1C harboring the wild-type version of 2B ...passage. Virus titers ranged from ... See full document
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Investigating the foot and mouth disease virus 3A protein
... on virus yield was reported by Monaghan et ...FMDV replication and the outcome of the experiment could be influenced by the ...vRNA replication may be masked by other beneficial effects on infection ... See full document
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Identification of T-Cell Epitopes in Nonstructural Proteins of Foot-and-Mouth Disease Virus
... animals analyzed. In general, the responses were dose depen- dent, and the higher SI were obtained with nitrocellulose- bound protein at from 0.5 to 2.5 g/ml. Figure 1C shows the peak responses found in each of ... See full document
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Chemiluminescence Immunoassay for the Detection of Antibodies against the 2C and 3ABC Nonstructural Proteins Induced by Infecting Pigs with Foot-and-Mouth Disease Virus
... the 2C and 3B epitopes to decrease the number of false-positive results generated by proteins produced in Escherichia ...from 2C and 3B to detect sera with a known status; however, the rate of concordance ... See full document
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Interaction of Foot-and-Mouth Disease Virus Nonstructural Protein 3A with Host Protein DCTN3 Is Important for Viral Virulence in Cattle
... FMDV replication in infected ...3A protein that mediate the protein interaction with DCTN3 by mutational analysis and, based on that information, we developed a mutant harboring the same mutations in ... See full document
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Employing transposon mutagenesis to investigate foot-and-mouth disease virus replication
... trations, replication-competent insertion sites were readily identified in 3A, with 16 separate 3A insertions identified across the two ...controls. Protein lysates were prepared at 8 h post-transfection ... See full document
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Foot-and-Mouth Disease Virus, but Not Bovine Enterovirus, Targets the Host Cell Cytoskeleton via the Nonstructural Protein 3Cpro
... trin– ␥-tubulin complexes to be transported along microtubules to the centrosome (60, 82). Using an antibody specific for pericentrin, we examined the effects of FMDV infection on the centrosomal structure. In uninfected ... See full document
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Role of RNA Structure and RNA Binding Activity of Foot-and-Mouth Disease Virus 3C Protein in VPg Uridylylation and Virus Replication
... the replication of picornavirus ...the foot-and-mouth disease virus (FMDV) 5 ⴕ untranslated region but outside of the cre/bus can enhance VPg uridylylation ...3C protein alone ... See full document
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Development of a foot and mouth disease virus replicon system for the study of RNA replication
... RNA replication and to improve our understanding of the viral life cycle: a process which will aid in the production of a new generation of live-attenuated vaccine candidate ...fluorescent protein (GFP) ... See full document
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The foot-and-mouth disease virus leader proteinase gene is not required for viral replication.
... viable virus, but cells transfected with RNAs that utilized the second AUG to drive translation of the viral polyprotein produced viable ...(WT) virus, grew to slightly lower titers than WT virus in ... See full document
7
Foot-and-mouth disease virus and poliovirus particles contain proteins of the replication complex.
... proteins 2C, 3CD, 3C, and 3D, and the cellular protein actin, are present in highly purified preparations of foot-and-mouth disease virus (FMDV) and ...the nonstructural ... See full document
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Comparative Genomics of Foot-and-Mouth Disease Virus
... of foot-and- mouth disease virus (FMDV) representing all seven serotypes and including the first complete sequences of the SAT1 and SAT3 ...SAT virus lineage containing ... See full document
18
Role of Nonstructural Proteins 3A and 3B in Host Range and Pathogenicity of Foot-and-Mouth Disease Virus
... of virus and examined to determine the lowest dose of virus able to cause complete CPE at 48 h, and these results were expressed as TCID 50 ...single-VPg virus was ⬃100 times lower in FPK cells. In ... See full document
11
Expression of Porcine Fusion Protein IRF7/3(5D) Efficiently Controls Foot-and-Mouth Disease Virus Replication
... This information is instrumental in supporting future experi- ments to explore if the use of Ad5-poIRF7/3(5D) will allow Ad5- poIFN dose sparing to protect animals from FMD. IBRS-2 cells have traditionally been used to ... See full document
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A Single Amino Acid Substitution in Nonstructural Protein 3A Can Mediate Adaptation of Foot-and-Mouth Disease Virus to the Guinea Pig
... of foot-and-mouth disease virus (FMDV) to the guinea pig have been ...the virus directly recovered from the lesions developed by the animals revealed the selection of variants with two ... See full document
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Foot-and-Mouth Disease Virus Modulates Cellular Vimentin for Virus Survival
... the virus ex- hibited reduced virus ...the virus from the rest of the cell, con- sequently serving as an initial site of ...viral replication or viral protein 2C is produced the ... See full document
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Use of Confocal Immunofluorescence Microscopy To Localize Viral Nonstructural Proteins and Potential Sites of Replication in Pigs Experimentally Infected with Foot-and-Mouth Disease Virus
... cellular replication of FMDV in infected ...FMDV replication—immunolabeling, which detects viral non- structural protein 3ABC, and RT-PCR, which provides numer- ical data on actual viral RNA copy ... See full document
9
The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication
... of virus entry and/or fusion of viral membranes with intracellular endosomal ...picornavirus, foot-and-mouth disease virus (FMDV), a member of the genus Aphthovirus and an important ... See full document
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The broad spectrum antiviral drug arbidol inhibits foot and mouth disease virus genome replication
... 2B protein move from the large juxtanuclear dots back to the diffuse cytoplasmic ER staining pattern, and after ...2B protein re-establish their punctate perinuclear staining ...of replication ... See full document
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