[PDF] Top 20 Multiple Pathways of Escape from HIV Broadly Cross-Neutralizing V2-Dependent Antibodies
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Multiple Pathways of Escape from HIV Broadly Cross-Neutralizing V2-Dependent Antibodies
... Broadly cross-neutralizing (BCN) antibodies are likely to be critical for an effective HIV ...such antibodies and their relationship with autologous viral evolution is ...BCN ... See full document
13
Immune escape by human immunodeficiency virus type 1 from neutralizing antibodies: evidence for multiple pathways.
... We have previously shown that neutralization resistance of an escape mutant with an amino acid substitution in the transmembrane protein (A582T) occurs because of alteration of a conform[r] ... See full document
8
Mechanisms of escape from the PGT128 family of anti HIV broadly neutralizing antibodies
... Residues in V3 can modulate promiscuous binding to the mannose‑patch The difference in sensitivity of the 3AA N295 N334 and 7AA N295 N334 viruses to neutralization by PGT128 (Fig. 3a) suggests that the ability of the ... See full document
15
The expanding array of HIV broadly neutralizing antibodies
... between escape virus populations and antibodies in vivo [114, ...against HIV? An alternative consideration to what we can learn from bnAbs is how can we practically use the expanding array of ... See full document
12
Development of broadly neutralizing antibodies in HIV 1 infected elite neutralizers
... Env escape patterns, providing a template for vaccine ...shorter pathways to breadth. The insights from these studies have been harnessed for the development of optimized immunogens, novel vaccine ... See full document
14
Sequences in Glycoprotein gp41, the CD4 Binding Site, and the V2 Domain Regulate Sensitivity and Resistance of HIV-1 to Broadly Neutralizing Antibodies
... of HIV, such as SF162 (36), ...by multiple HIV-infected ...people from different parts of the world who are infected with different clades of virus, leading to the production of bNAbs that ... See full document
10
Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies
... lower HIV-1 infection risk and declines soon after ...cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene ... See full document
16
Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies
... encoding broadly HIV-1-neutralizing human monoclonal antibodies (MAbs) are highly divergent from their germ line ...the broadly neutralizing (bn) Abs and that ... See full document
9
Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop
... of antibodies elic- ited in natural infection and that mediate neutralization breadth and potency is key in the design and development of suitable Env- based immunogens capable of eliciting similar antibody ... See full document
12
HIV 1 clade C escapes broadly neutralizing autologous antibodies with N332 glycan specificity by distinct mechanisms
... the HIV-1 envelope (Env) is a target for broadly neutralizing antibodies (bnAbs) such as PGT121 and ...of HIV-1 clade C Envs obtained from broadly cross ... See full document
9
Broadly Neutralizing Antibodies Developed by an HIV-Positive Elite Neutralizer Exact a Replication Fitness Cost on the Contemporaneous Virus
... with HIV-1 develop broad and potent serum cross-neutralizing antibody ...viral escape from contemporaneous potent and broad serum neutralizing anti- bodies developed by an elite ... See full document
10
Broadly Cross-Neutralizing Antibodies in HIV-1 Patients with Undetectable Viremia
... sera from ART patients showed a strong inhibition of the ...sera from the immunoglobulin- mediated effect, we decided to purify IgGs from all the sera that showed good viral inhibition and analyzed ... See full document
10
Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms
... elicit antibodies (Abs) with broad strain recogni- tion that bind to regions that are difficult to mutate for ...which broadly neutralized all MNV strains tested. Importantly, escape mutants ... See full document
19
The potential of broadly neutralizing HIV antibodies to function as microbicides
... OF BROADLY NEUTRALIZING ANTIBODIES AGAINST ALTERNATIVE INOCULA ...of HIV microbicides use models of cell-free HIV infection; however in the context of sexual transmission, ... See full document
107
Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies
... indistinguishable from a wild type virus, and can elicit direct responses by binding sur- face Ig on B cells, as well as bind target cells through CD4 and CCR5, induce all of the conformational changes, and expose ... See full document
6
HIV 1 cell to cell transmission and broadly neutralizing antibodies
... cell-associated HIV-1 [151, ...free HIV-1 (reviewed in ...cell-associated HIV-1 in vitro, requir- ing higher concentrations than during cell-free infection [116, ...of antibodies to confer ... See full document
14
Signature Biochemical Properties of Broadly Cross-Reactive HIV-1 Neutralizing Antibodies in Human Plasma
... of broadly cross-reactive HIV-1 neutralization antibodies found in certain HIV-1-infected individuals holds significant value for understanding natural and vaccine-mediated ... See full document
12
Towards HIV 1 remission: potential roles for broadly neutralizing antibodies
... data from macaque studies are inconclusive in terms of viral clearance ...control HIV and inter- fering with the latent reservoir are also necessary to achieve ... See full document
10
Epitope Mapping of Broadly Neutralizing HIV-2 Human Monoclonal Antibodies
... by HIV-2 leads to the elicitation of high titers of broadly neutralizing antibod- ies (NAbs) against primary HIV-2 strains ...monoclonal antibodies (MAbs), 14 of which were newly ... See full document
14
Anti-gp41 Antibodies Cloned from HIV-Infected Patients with Broadly Neutralizing Serologic Activity
... constructed from patients and that were selected on recombinant gp41 showed a much lower frequency of cluster I binders (5 out of 25) ...by multiple rounds of selection and amplification; in addition, the ... See full document
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