[PDF] Top 20 One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment
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One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment
... tumor cells by secreting adipokines including interleukin- 8 (IL-8) and also make tumors grow rapidly by providing fatty acids ...by tumor-associated macrophage (TAM), NK cells, T ... See full document
10
Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors
... Mesenchymal stem cells (MSCs) are multipotent adult stem cells of mesodermal germ layer origin that possess an innate ability for self-renewal and are capable of dif- ferentiating into ... See full document
15
Granulocyte-like myeloid derived suppressor cells (G-MDSC) are increased in multiple myeloma and are driven by dysfunctional mesenchymal stem cells (MSC)
... BM mesenchymal stem cells (MSC) are essential components in the formation and function of the BM microenvironment ...adult stem cells with an important role into the tumor ... See full document
12
The pro and anti tumor roles of mesenchymal stem cells toward BRCA1 IRIS overexpressing TNBC cells
... epithelial cells or luminal A/ER + cells converts them into genuine TNBC cells expressing basal bio- markers, epithelial-to-mesenchymal (EMT) inducers, and stemness enforcers, but lacking ... See full document
23
Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation
... where tumor cells reside is called the tumor microenvironment (TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM), stromal cells, ... See full document
11
Interaction of tumor cells with the microenvironment
... (CAFs), mesenchymal stem cells (MSC), and a variety of different immune cells including lymphocytes and tumor-associated macro- phages ...these multiple interactions with the ... See full document
8
Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm
... target cells residing in the microenvironment or carried to distant sites via bio- logical fluids ...and tumor susceptibility gene 101 (TSG101); however, they also have unique tissue type-specific ... See full document
8
Effects of pericytes and colon cancer stem cells in the tumor microenvironment
... Endothelial cells (ECs) that line the inner surface of vessels, directly participate in oxygen delivery, nutrient supply, and removal of waste ...endothelial cells (ECs) secrete plate- let-derived growth ... See full document
12
Mesenchymal stem cells in the osteosarcoma microenvironment: their biological properties, influence on tumor growth, and therapeutic implications
... the tumor resembling leiomyo- sarcoma much more than OS ...phenotype development. Calcium substrates can also contribute to the development of p53 −/− RB −/− MSC osteogenesis ...the tumor ... See full document
9
The roles of mesenchymal stem cells in tumor inflammatory microenvironment
... these cells, which could recruit immunosup- pressive cells such as CD11b + Ly6C + monocytes, F4/80 + macrophages, and CD11b + Ly6G + neutrophils to lymphoid ...L-MSC-mediated tumor-promoting effects ... See full document
10
Breast cancer stem cells, cytokine networks, and the tumor microenvironment
... of cells that display stem cell proper- ties, mediate metastasis, and contribute to treatment ...cancer stem cells (CSCs) are regulated by complex interactions with the components of ... See full document
7
TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function
... T cells produce pro- or anti-inflammatory ...T cell cytokine ...helper cells (Th1, Th2, Th17, and T reg) and cytotoxic T cells (Tc1, Tc2, Tc17, and T ...T cells. After 3 days, T ... See full document
15
Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance
... of tumor pathologic features ...in tumor with MMR defects by T-cells, macrophages, and natural killers, infiltration might be increased enhancing immune surveillance mechanisms ...of tumor ... See full document
11
EMT, CTCs and CSCs in tumor relapse and drug-resistance
... cancer stem cells (CSCs), which are highly resistant to ...circulating tumor cells (CTCs) of some cancer patients manifest phenotypes of both CSCs and epithelial-mesenchymal transition ... See full document
15
EMT and tumor metastasis
... Another exciting area of research is the use of EMT markers in the analysis of circulating tumor cells (CTC). Diagnostically, CTC has been a mainstay of clinical prac- tice in assessment of metastasis and ... See full document
13
Accumulation of FOXP3+T-cells in the tumor microenvironment is associated with an epithelial-mesenchymal-transition-type tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma
... for tumor marker prognostic studies ...gender, tumor diameter, number of positive lymph nodes and total number of lymph nodes harvested, TNM stage (7th Edition), perineural, as well as blood vessel and ... See full document
12
Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production
... in tumor development of breast and colon cancer ...cancer cells stimulated secretion of IL-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant ... See full document
14
Targeting microenvironment in cancer therapeutics
... non-tumor cell compartments in the past, significant challenges still lie ahead for implementing stromal targeting strategies in clinical ...is one of the few cancers for which survival has not been ... See full document
9
The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells
... cancer cells show strong nuclear accumulation of hypoxia- inducible factor 1α (HIF-1α) protein ...stemcell-like tumor cells in neuroblastomas [18, 19] or gliomas ...conditions, tumor ... See full document
15
Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges
... regulate stem cell differentiation either directly or indirectly and are frequently deregulated in tumors ...gastric stem cells are such a rare population of cells and can be affected ... See full document
11
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