[PDF] Top 20 Mutational analysis of human papillomavirus type 16 E7 functions.
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Mutational analysis of human papillomavirus type 16 E7 functions.
... Whereas the immortalizing function transformation in conjunction with activated ras for primary rat cells paralleled the transforming function for rat 3Y1 cells, the transformation funct[r] ... See full document
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Systematic Analysis of Residues in Conserved Region 3 of the Human Papillomavirus 16 E7 Oncoprotein
... HPV E7 in cellular transformation and cancer progression has been extensively studied, we still do not fully understand how E7 deregulates one of its most vital interacting partners, the retinoblastoma ... See full document
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Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein.
... in E7-immortalized mammary epithelial cells and provided evidence for the involvement of the ubiq- uitin-mediated proteolysis pathway in pRB degradation in these cells ...or E7-expressing RKO ...and ... See full document
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Leaky Scanning Is the Predominant Mechanism for Translation of Human Papillomavirus Type 16 E7 Oncoprotein from E6/E7 Bicistronic mRNA
... HPV type 16 (HPV-16) and related types are classed as high-risk viruses because of their association with high-grade CIN and cervical carcinoma (reviewed in reference ...Transcriptional ... See full document
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A point mutational analysis of human papillomavirus type 16 E7 protein.
... It is evident from these studies that mutants which destroy both transforming and trans-activation activities p24GLY and mutants which are transformation competent but express no or very[r] ... See full document
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Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene.
... developed skin tumors late in life (Table 1). Grossly, these tumors belong to two classes, relatively small (,1 cm) but highly keratotic lesions and large, cystic but nonkeratotic le- sions. These tumors arose on the ... See full document
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The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19ARF
... anogenital human papillomaviruses (HPVs) is present ...HPV type 16 [HPV-16] and HPV-18) and the low-risk types commonly found in genital warts (HPV-6 and ...The E7 proteins from high- ... See full document
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The Human Papillomavirus Type 16 E7 Oncogene Is Required for the Productive Stage of the Viral Life Cycle
... oncogene E7 is not necessary for HPV-16 DNA replication during the nonproductive stage of the viral life ...of E7 in the HPV-16 life ...the E7-deficient HPV-16 genome episo- ... See full document
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Human Papillomavirus Type 16 E6/E7 Upregulation of Nucleophosmin Is Important for Proliferation and Inhibition of Differentiation
... a clear role for NPM in suppression of differentiation. NPM is a nucleolar phosphoprotein that shuttles between the nucleus and the cytoplasm and takes part in various cellular processes. It has several interacting ... See full document
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Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.
... Specifically, each displays oncogenic activity in the form of ras cooperativity, each encodes proteins that can trans-activate transcription as measured by activation of the adenovirus E[r] ... See full document
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Systematic Analysis of the Amino Acid Residues of Human Papillomavirus Type 16 E7 Conserved Region 3 Involved in Dimerization and Transformation
... wild-type E7 or our novel collec- tion of mutants to transform primary BRK cells in cooperation with ...wild type in this ...in E7, M84S and QKP96-98EEA, were identified as causing decreased ... See full document
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Destabilization of the Retinoblastoma Tumor Suppressor by Human Papillomavirus Type 16 E7 Is Not Sufficient To Overcome Cell Cycle Arrest in Human Keratinocytes
... Human papillomavirus (HPV) infects the basal cells of strat- ified squamous epithelia and replicates in the suprabasal lay- ...HPV type 16 (HPV16) (71). The E7 oncoprotein of HPV16 is ... See full document
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Genetic variability in E6 and E7 oncogenes of human papillomavirus Type 16 from Congolese cervical cancer isolates
... and E7 genes using type-specific primers PCR and direct ...Genetic analysis revealed 18 and 4 nucleotide changes in E6 and E7 genomic regions ...H78Y. E7 genomic region was found to be ... See full document
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Regulation of Human Papillomavirus Type 16 E7 Activity through Direct Protein Interaction with the E2 Transcriptional Activator
... of E7’s trans- forming activity and an increase in its stability in the presence of E2; we were then interested in seeing whether E7 might interfere with the functions of ...of E7 with E2 on ... See full document
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Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7
... that E7 induces multiubiquitina- tion of ...that E7-mediated pRB degra- dation by the proteasome may not require ubiquitination, add- ...HPV-16 E7 destabilizes p130. (A) Decreased p130 ... See full document
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Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells.
... ) to screen for mutant clones. Cys-63 Ser, Cys-63 Arg, and Cys-106 Arg were created by site-directed mutagenesis, using the oligonucleo- tides 59 ggg CAT ATG CTG TA(T/G) GTG 39 and 59 cgg TCC GGA CAC AGT TTC TTT TGA ... See full document
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Different Methods of Identifying New Antigenic Epitopes of Human Papillomavirus Type 16 E6 and E7 Proteins
... or E7-vac-infected autologous EBV-LCL (data not ...an E7 specificity, as shown by a chromium release assay ...the E7 protein, the epitope recognized by this T-cell clone was shown to be in the ... See full document
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Inhibition of Human Papillomavirus Type 16 E7 Phosphorylation by the S100 MRP-8/14 Protein Complex
... of functions, with consequent effects on gene expression, pro- tein synthesis, cell cycling, and differentiation (15, ...of E7 phosphorylation mediates the HPV- specific ...for E7 phosphorylation, ... See full document
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Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters.
... Cells were transfected with pSV2CAT contains the SV40 enhancer and early promoter upstream of the CAT gene, no DNA none, a construct containing the wild-type HPV-18 LCR upstream of the C[r] ... See full document
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Mutational analysis of human papillomavirus type 11 E5a oncoprotein.
... charges at the COOH terminus may cause a transformation defect. For example, substitution of an uncharged Gln for a charged amino acid at position 83 (His) and substitution of a charged His for an uncharged amino acid at ... See full document
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