[PDF] Top 20 Natural Suppression of Human Immunodeficiency Virus Type 1 Replication Is Mediated by Transitional Memory CD8+ T Cells

... HIV replication is suppressed in vitro by a CD8 ⴙ cell noncytotoxic antiviral response ...of CD8 ⴙ cell subsets having strong CNAR activity. CD8 ⴙ cell subset frequencies and CNAR levels were ... See full document

... ⴙ T cells are the primary sites of human immunodeficiency virus type 1 (HIV-1) replication in ...antigen-presenting cells (APCs), such as dendritic ... See full document

... CD4 1 T lymphocytes per ml and from uninfected healthy ...with 1% phyto- hemagglutinin (PHA) (Difco Laboratories, Detroit, ...These cells were used within 2 weeks of preactivation, when they ... See full document

... and memory T lymphocytes (43), it is usually thought that entry of HIV-1 occurs at similar rates in these two distinct cell ...external virus-en- coded envelope glycoprotein gp120 and ... See full document

... ⫹ T cells reflects the response of HIV-1-specific CTLs in vivo much better than cytokine production by such clones stimulated with peptide-pulsed ...⫹ T cells revealed that only 7 to 9% ... See full document

... viral replication in either monocytes ...target cells) was noted in some assays but was always weaker than inhibition by MHC-matched CTL clones (data not ...shown). Suppression of viral ... See full document

... of T cells ...HIV-1 replication and cell ...mononuclear cells, of histamine by basophils (15), and of superoxide anions by monocytes (28) was similarly affected by SRIH; so too was ... See full document

... (Table 1). Eval- uation of non-HIV-1-specific CTL also indicated that CTL with other specificities are capable of producing MIP or RAN- TES upon specific ...the T-tropic HIV-1 IIIB by CTL ... See full document

... HIV replication via several distinct mechanisms that are not mutually ...viral replication in freshly isolated PBMC, which contains a small fraction of activated or partially activated T cells ... See full document

... HIV-1 replication in PBMC, T-cell lines, and monocytoid cell lines have been demonstrated (8, 28, 32, 33, 40, 70, 80, 81), and IFN-␥ has pleiotropic effects on HIV-1 replication in ... See full document

... of human immunodeficiency virus type 1 (HIV-1)-specific CD8 ⫹ T cells with disease pro- gression remains ...HIV-1-specific CD8 ⫹ T ... See full document

... HIV-1 suppression was calibrated using the following calibration proteins (Sig- ma): thymus globulin (669 kDa), ferritin (440 kDa), catalase (232 kDa), aldolase (158 kDa), albumin (67 kDa), ovalbumin (45 ... See full document

... in T cells and monocytes and cooperates with Tat to enhance ...in T cells and monocytes, the natural ISG15 promoter was induced more efficiently by IFNA2 than the three copies of ISREs, ... See full document

... it virus spe- cific through the direct interaction of the hybrid receptor with gp120 on the surface of infected cells, bypassing the need for antigen processing ...These cells were efficient ... See full document

... ⫹ T cells ...viral replication in light of these escape ...viral replication (5, 6, 14, ...wild type occurs when the virus is transmitted to HLA-B*57-negative individuals ...or ... See full document

... of suppression occurred when the effector and target cells were class I and class II disparate or were similar at only one class II ...better suppression than class II mismatches and vice ... See full document

... Progressive human immunodeficiency virus type 1 (HIV-1) infection is often associated with high plasma virus load (pVL) and impaired CD8 ⴙ T-cell function; ... See full document

... FIG. 1. Noncytolytic suppression of HIV-1 by secreted membrane fractions from a CD8 ⫹ T-cell ...line. Suppression of HIV-1 replication in an acute infectious assay ... See full document

... ciency virus type 1 (anti-HIV-1) suppressive activity of CD8 1 T ...mononuclear cells and purified CD8 1 T ...restricted. Suppression of ... See full document

... A201.R5 cells in CM and were incubated at for the required time with or without the addition of ...using 1⫻ Eurogentec Mastermix (Eurogentec, ...between cells with differing efficiency of ... See full document