[PDF] Top 20 Study of negative pressure wound therapy as an adjunct treatment for acute burns in children (SONATA in C): protocol for a randomised controlled trial

... young children differ markedly from adults in skin thickness and composition [132, 133], body surface area [134], and formation rates of granulation tissue ...the therapy in children indicating that ... See full document

... of wound care, and to compare the benefit of various forms of NPWT for acute and chronic wounds with regard to patient-relevant outcomes on the basis of the published ...conventional wound ... See full document

... burn wound care, it was reported that hydrogel dressings conform well to the wound bed, are quick and easy to apply, and allow for wound inspection through the dressing ...ness burns and act ... See full document

... this trial will reflect that of the surgery, with the attending clinician assessing capacity before taking consent for the surgical procedure, and this capacity assessment then being used to decide on the proper ... See full document

... are children with a burn injury who are managed in the acute phase post burn (up to 16 years of age, as per current practice) or who receive burn scar reconstructive surgery (up to 18 years of age, as per ... See full document

... most wound types, a key area of uncertainty is the clinical and cost effectiveness of NPWT in the treat- ment of severe pressure ...ulcers. Pressure ulcers (also called bed/pressure sores or ... See full document

... severe burns involves meticulous wound care in order to prevent ...of wound care is recognised as one of the most painful procedures that can be undertaken, with some patients reporting severe to ... See full document

... proposed trial the cost-effectiveness of negative pressure wound therapy in this clinical popula- ...proposed trial, and also by data collected from other primary and secondary ... See full document

... (including wound infection, intra- abdominal abscess and adhesional small bowel obstruction) is up to 25% [3], with a need for hospital readmission in 4 – 5% of cases [4, ...for acute appendicitis in 19 ... See full document

... the study is not powered to detect clinically important treatment ...surgery, wound infection), along with the stratification factor (baseline wound size) used in the randomisation for this ... See full document

... the wound apposed with sutures or ...best treatment for these complex wounds, with limited robust evidence regarding the clinical and cost-effectiveness of different dressings and treatments; one such ... See full document

... iron-deficient children. However, a community-based randomised con- trolled trial in Zanzibar designed to evaluate the impact of zinc and iron plus folic acid supplementation on morbidity and ... See full document

... reliable protocol adherence. At the design phase of the trial we noted that the published scientific literature on all these aspects was ...FEAST trial recently published indicates that of 1422 ... See full document

... with acute intracerebral haemorrhage, rapid blood pressure lowering may be effective and is recommended in international guidelines [3, ...with acute ischaemic stroke, the benefit of acute ... See full document

... human study, in which significant positive regulatory effects were reported, directly via radioimmunoassay and/or enzyme-immunoassay or quan- titative real-time polymerase chain reaction (qRT-PCR) analysis ... See full document

... in children have long been neglected owing to the perception that paediatric TB is not a public health ...a study endpoint ...where children are diagnosed, treated and monitored predominantly using ... See full document

... Music Therapy Clinic for Research and ...Every therapy session will be video recorded for data collection and ...music therapy clinicians who have committed to the study have professional ... See full document

... overall study population, assuming an effect that leads to a 7% absolute risk reduction (ARR) in poor functional outcome (mRS 3 to 6) in the GTN group compared with controls (48% vs ...simulation study with ... See full document

... the trial will be used for transitions between states, costs and ...for treatment of ...the trial we will follow rec- ommended best practice in identifying and synthesising the best available ... See full document

... individually randomised trials: in a meta-analysis that includes both cluster and individually randomised trials, or cluster-randomised trials with different types of clusters, possible differences ... See full document