[PDF] Top 20 A neuronal function of the tumor suppressor protein merlin
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A neuronal function of the tumor suppressor protein merlin
... the tumor burden ...nerve tumor burden, suggesting that factors other than gross tumor growth might be responsible for this disorder ...gross tumor load along peripheral nerves often lacks a ... See full document
10
Sro7p, a Saccharomyces cerevisiae Counterpart of the Tumor Suppressor l(2)gl Protein, Is Related to Myosins in Function
... MYO2 suggest that Sro7p plays a positive role in the Myo2 pathway. Myo2p is concentrated in the bud during bud growth, and it is critical for polarized cell growth and for vectorial transport of secretory vesicles to the ... See full document
12
Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts?
... of function for multiple interaction types ...important protein-protein interactions within the large pocket region ...pRB function will hopefully pave the way for a more rational ... See full document
15
Activation of tumor suppressor protein PP2A inhibits KRAS driven tumor growth
... substantial tumor-growth inhibition compared with vehi- cle ...a tumor-suppressor ...subunit function in the ABC holoenzymes is essential for SMAP activity ... See full document
11
Original Article SOX1 suppresses cell growth and induces apoptosis by regulating Wnt/β-catenin signaling pathway in gastric cancer
... eration and apoptosis. The transfect efficiency was confirmed on both mRNA and protein lev- els (Figure 2A, 2B). Then, results of MTT assay showed that ectopic expression of SOX1 signifi- cantly inhibited GC cells ... See full document
6
Transformation by E1A Oncoprotein Involves Ubiquitin-Mediated Proteolysis of the Neuronal and Tumor Repressor REST in the Nucleus
... its function with concomitant neuronal gene expres- sion has been implicated in several human tumors, such as breast, prostate, ovarian, colorectal, and pancreatic cancers (9, 18, ...for neuronal ... See full document
9
Detection of JC Polyomavirus tumor antigen in gastric carcinoma: a report from Iran
... multifunctional protein with the ability to bind and inactivate tumor suppressor proteins in- cluding pRb and ...and tumor suppressor genes and various cancers such as gastric cancer ... See full document
9
Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma
... gain-of- function on NB tumorigenicity in vivo, we generated cohorts of xenografts in athymic immunodeficient nude mice via orthotopic injection into the renal capsule as previously described ...in tumor ... See full document
9
The Coronavirus Endoribonuclease Nsp15 Interacts with Retinoblastoma Tumor Suppressor Protein
... pRb function. Oncoproteins from DNA tumor viruses can bind pRb and induce NIH 3T3 cells to undergo contact- independent cell growth in a focus formation assay (9, 11, 21, 23, 29, ... See full document
11
von Hippel–Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia inducible factor 2α signaling and splenic erythropoiesis
... (VHL) tumor suppressor protein (pVHL) is unique in that it is not associated with tumor development, but rather with Chuvash polycythemia, a heritable disease char- acterized by elevated ... See full document
12
A Genetic Screen for Dominant Modifiers of a cyclin E Hypomorphic Mutation Identifies Novel Regulators of S-Phase Entry in Drosophila
... the tumor suppressor protein, Retinoblastoma is controlled by the activity of the Cyclin-dependent ser/ (Rb; Lundberg and Weinberg 1998), which functions thr protein kinases (Cdks) associated ... See full document
26
Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer
... junctional protein involved in cell-cell ...scaffolding protein that functions in multiple signaling cascades including Wnt, p53, and transforming growth factor β (TGFβ) pathways [25, ...Axin protein ... See full document
15
The function, regulation and therapeutic implications of the tumor suppressor protein, PML
... the transition between two progenitor types, radial glial cells and basal progenitors, is disrupted [57]. These data suggest a role for PML in brain development. Interest- ingly, the number and size of PML NBs are ... See full document
14
The False Paradigm of RUNX3 Function as Tumor Suppressor in Gastric Cancer
... The issue of detecting Runx3 by IHC requires specific attention. As alluded to above, a detailed survey of the spatio-temporal expression of Runx3 and Runx1 proteins during embryonic development, using IHC, was ori- ... See full document
10
The neuronal RNA binding protein HuB as a potential tumor suppressor in glioblastoma
... p21 tumor suppressor is translationally enhanced by HuB in mouse neural tube ...known tumor suppressor gene which is indirectly transcriptionally targeted in glioblastomas by both inactivating ... See full document
63
Role of maspin in cancer
... regulating tumor metastasis. This review describes a tumor suppressor gene, Maspin, which is often silenced in cancer cells and exhibits suppressing activity against tumor growth and metasta- ... See full document
19
In Silico Analysis of the Protein Structure of Tumor Suppressor Genes in Humans
... similar protein structure (tertiary protein structure) in members of the same cluster pointing that all members in each cluster exhibit similar protein ... See full document
6
Mitochondria, cholesterol and cancer cell metabolism
... interacting protein 3 (BNIP3) and BNIP3-like (BNIP3L), which trigger mitochondrial autophagy, thereby decreas- ing the oxidative metabolism of both fatty acids and glu- cose ...and function, but also ... See full document
24
Original Article Investigating RASSF1A hypermethylation and endometrial carcinoma occurrence and development using in vivo and in vitro demethylation of 5-AZA-2’-deoxy cytidine
... DNA methylation is a common epigenetic molecular mechanism that involves reversible chemical modification. This occurs when the enzyme DNA methyltransferase (DNMT) adds a methyl group onto a cytosine base [18]. In con- ... See full document
11
Two Distinct Activities Contribute to the Oncogenic Potential of the Adenovirus Type 5 E4orf6 Protein
... E4orf6 protein (data not ...dl1-203 protein (dl1- 203/L245P) resulted in cytoplasmic restriction ...full-length protein did not abolish nuclear localization shows that E4orf6 contains at least one ... See full document
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