[PDF] Top 20 Nuclear Import Defect of Human Immunodeficiency Virus Type 1 DNA Flap Mutants Is Not Dependent on the Viral Strain or Target Cell Type
Has 10000 "Nuclear Import Defect of Human Immunodeficiency Virus Type 1 DNA Flap Mutants Is Not Dependent on the Viral Strain or Target Cell Type" found on our website. Below are the top 20 most common "Nuclear Import Defect of Human Immunodeficiency Virus Type 1 DNA Flap Mutants Is Not Dependent on the Viral Strain or Target Cell Type".
Nuclear Import Defect of Human Immunodeficiency Virus Type 1 DNA Flap Mutants Is Not Dependent on the Viral Strain or Target Cell Type
... cPPT mutants of strains LAI, YU-2, and HXB2 all had severe defects in infectivity relative to the wild-type controls ...wild-type virus exhibited an unaccountable replication defect, ... See full document
8
Novel Nuclear Import of Vpr Promoted by Importin α Is Crucial for Human Immunodeficiency Virus Type 1 Replication in Macrophages
... active nuclear import of the viral PIC (4). The HIV-1 PIC contains viral proteins such as reverse transcriptase, integrase (IN), nucleocapsid (NC), Vpr, and ma- trix (MA; p17) in ... See full document
10
Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A.
... compounds, viral stocks produced by a cloned HIV-1 provirus were propagated in CD4 1 HeLa cells (21) in the presence of ...Four viral stocks capable of replicating in the presence of ... See full document
7
The Karyophilic Properties of Human Immunodeficiency Virus Type 1 Integrase Are Not Required for Nuclear Import of Proviral DNA
... of nuclear accumulation in mutants L, Q, and LQ was associated with a drastic reduc- tion of the multimerization of IN in viral ...the virus, did not impair nuclear localization or ... See full document
8
Evidence for a Functional Link between Uncoating of the Human Immunodeficiency Virus Type 1 Core and Nuclear Import of the Viral Preintegration Complex
... in target cells. In a previous study, we reported that the HIV-1 CA mutant Q63/67A was unusual: despite the reduced stability we observed for the mutant cores, the particles were compe- tent for reverse ... See full document
9
Cyclophilin A-Dependent Restriction of Human Immunodeficiency Virus Type 1 Capsid Mutants for Infection of Nondividing Cells
... CA mutants synthesized equivalent quantities of two-LTR circles in divid- ing and nondividing cells, arguing against a specific effect on nuclear ...wild type (our unpublished observations), ... See full document
8
Contribution of the C terminal tri lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import
... protein nuclear local- ization and their inability to bind to karyopherin α in vitro ...these mutants during HIV-1 replication, other studies did not reveal the importance of these IN mutants ... See full document
15
Nuclear Localization of Human Immunodeficiency Virus Type 1 Preintegration Complexes (PICs): V165A and R166A Are Pleiotropic Integrase Mutants Primarily Defective for Integration, Not PIC Nuclear Import
... host cell factors to gain nuclear entry even when cells disassemble their nuclear ...HIV-1 nuclear localization under these conditions, we characterized viral replication and ... See full document
10
Wild-Type Levels of Nuclear Localization and Human Immunodeficiency Virus Type 1 Replication in the Absence of the Central DNA Flap
... leukemia virus requires cell division to establish a productive infection (24, 32, ...nondividing cell nuclei by an energy-dependent process (6), Moloney murine leukemia virus requires ... See full document
9
Reassessment of the Roles of Integrase and the Central DNA Flap in Human Immunodeficiency Virus Type 1 Nuclear Import
... PIC nuclear import still requires further investigation, and these studies may be obscured by several potential ...achieve import by recruiting cellular NLS- containing proteins rather than by ... See full document
10
Proline Residues in Human Immunodeficiency Virus Type 1 p6Gag Exert a Cell Type-Dependent Effect on Viral Replication and Virion Incorporation of Pol Proteins
... HIV-1-positive human serum (1:200), mouse monoclonal antibody (MAb) against RT (1:400; BTI), or rabbit polyclonal serum against integrase ... See full document
9
Cytoplasmic Utilization of Human Immunodeficiency Virus Type 1 Genomic RNA Is Not Dependent on a Nuclear Interaction with Gag
... for virus particle formation, the encapsidation efficiency could be an- alyzed in the absence and presence of ...plasmid. Virus parti- cles were purified from the supernatant of the transfected cells by ... See full document
13
Human Immunodeficiency Virus Type 2 Produces a Defect in CD3-γ Gene Transcripts Similar to That Observed for Human Immunodeficiency Virus Type 1
... in viral pathogenesis. HIV-1 and HIV-2 have significant sequence di- vergence (640% homology, depending on the variant) (29), although the two viruses are similar in genomic organization, share mechanisms ... See full document
7
Induction of Indolamine 2,3-Dioxygenase in Primary Human Macrophages by Human Immunodeficiency Virus Type 1 Is Strain Dependent
... Quinolinic acid is produced de novo by the oxidative catab- olism of the essential amino acid tryptophan through the kynurenine pathway (5). The first and rate-limiting enzyme for this pathway is IDO, which can be ... See full document
6
Nuclear Import of the Preintegration Complex Is Blocked upon Infection by Human Immunodeficiency Virus Type 1 in Mouse Cells
... the viral life cycle (11, 27, 40, 42, 43, ...uninfected human cells (11, 52), indicating that the defects are due to the lack of necessary factors in rodent cells rather than the presence of dominant ... See full document
12
Circularization of human immunodeficiency virus type 1 DNA in vitro.
... Culture supernatant containing a high concentration of virus was Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Linear viral DNA present in cytoplasmic extracts of cel[r] ... See full document
11
Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.
... Table 1, neither the wild-type virus nor the V32I/V82I mutant showed any decrease in infectivity when the infection was done in the presence of the PR inhibitor at concentrations between ...inhibits ... See full document
5
Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants.
... The two regulatory protein coding regions for tat and rev that are essential for virus replication are intact, and transient expression of HIVgpt in COS7 cells results in assembly and re[r] ... See full document
10
Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent.
... of cell surface CXCR4 expression deter- mined by flow cytometry after 12G5 staining of the CD4 1 T-cell lines MOLT-4 and C8166, the CD4-transfected human rhabdomyosarcoma cell line RD, ... See full document
5
Genetic Analyses of DNA-Binding Mutants in the Catalytic Core Domain of Human Immunodeficiency Virus Type 1 Integrase
... bind DNA, and 16 of the 22 residues fell into this category (Table ...either viral or target DNA via in vitro activity (33, 43, 67, 68) or photo- cross-linking (28, 40, 41, 43, 56) assays ... See full document
13
Related subjects