[PDF] Top 20 Ongoing clinical trials of the pleiotropic effects of statins

... antiinflammatory effects, statins may reduce the risk of coronary events by contributing to plaque stabilization through effects on matrix metalloproteinases, macrophages, T cells, and vascular ... See full document

... of statins in protecting against vascular events irrespective of cholesterol status has prompted investigation of the pleiotropic effects of these ...immune-modulatory effects of ... See full document

... beneficial effects of statins on AF have been reported in several ...randomized clinical and large observational studies have shown similar result that show the beneficial effect of statins in ... See full document

... observational trials who were on statin therapy for cardio- vascular risk prevention revealed a 32% decreased risk of venous thromboembolism (P , ...that statins may be of particular benefit in cancer ... See full document

... as statins, a class of cholesterol lowering drugs reputed for their pleiotropic effects independent of cholesterol lowering are reported to play a crucial role in prevention and treatment of ...from ... See full document

... that statins exert their main effect by inhibiting cholesterol syn- thesis through the inhibition of the 3-hydroxy-3-methyl-glutaryl-CoA reductase ...The pleiotropic effects of statins, which ... See full document

... [4]. Statins promote eNOS activity through the AMP-activated pro- tein kinase (AMPK) and PI3K/Akt pathways ...antioxidant effects that decrease reactive oxygen species production ...by statins ... See full document

... It is now established that atherosclerotic plaques are hetero- geneous and vary in their tendency to undergo thrombosis and the consequent acute clinical events. Plaques rich in inflam- matory macrophages and ... See full document

... Once the process of homing and extravasation have taken place, the metastatic cells encounter native bone microenvironment cells. These cells play a vital role in maintaining homeostasis of the bone and include: osteo- ... See full document

... in clinical trials of HMG-CoA reductase inhibitors ...statin clinical trials conducted on cohorts of adults at elevated risk for cardiovascular ...of statins is based, in part, on the ... See full document

... group effects. So to separate the two effects, one needs to model participation with both factors in the ...many trials incorporated repeated measures also required some special ... See full document

... By 1997, almost 14,000 women had enrolled in the study. Half were randomized to receive tamoxifen, the rest placebo. The two funding agencies, the National Cancer In- stitute and the National Heart, Lung, and Blood ... See full document

... Eleven trials (20% of all ongoing trials using metformin as an anti-cancer agent; Tables 1-3) are focused on evaluating metformin as a treatment for breast ...two trials are using metformin as ... See full document

... the clinical diagnosis of ...from ongoing biomarker studies, future treatment and prevention trial, and pharmacodynamic modeling are expected to establish the appropriate level of BACE1 inhib- ition and ... See full document

... Demand-side measures undertaken in China include the development of an essential medicine list, clinical guidance and guidelines (30,33,35,46,47). However, currently there are limited measures being taken by ... See full document

... baseline clinical variables, including age, gender, BMI, HbA1c, FPG, lipid parameters, medications, and LDL-lowering therapy allocation (ezetimibe or ...various clinical pa- rameters and percent changes in ... See full document

... The treatment for early breast cancer has evolved over the past decade. Nowadays, there is an increasing demand for minimally invasive treatments for small breast cancer. Breast conservation therapy has largely replaced ... See full document

... In this study, we present the clinical results of a new absorbable punctual plug made of atelocollagen (Keeptear; Koken Bioscience Institutes, Tokyo, Japan). Atelocollagen is a collagen solution that is extracted ... See full document

... Chronic obstructive pulmonary disease (COPD) is charac- terised by irreversible air fl ow limitation and is currently the third leading cause of death worldwide in 2018. 1 Exertional dyspnoea, the most debilitating ... See full document

... Fourteen trials with 2866 participants were included in our ...the effects of statins were much stronger in subjects with pathologic albuminuria: change of − ...contrast, statins did not ... See full document