[PDF] Top 20 Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution
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Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution
... the V1/V2 deletion variants used in this ...⌬ V1/V2 ...the V1/V2 stem and the bridging ...variants 1, 2, and 8 and an overlay of these variants (right bottom panel, ... See full document
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Antigenicity and Immunogenicity of Transmitted/Founder, Consensus, and Chronic Envelope Glycoproteins of Human Immunodeficiency Virus Type 1
... Human immunodeficiency virus type 1 (HIV-1) vaccine development requires selection of appropriate envelope (Env) immuno- ...Env glycoproteins were examined for ... See full document
17
Evolution of CXCR4-Using Human Immunodeficiency Virus Type 1 SF162 Is Associated with Two Unique Envelope Mutations
... Human immunodeficiency virus type 1 (HIV-1) isolated from infected individuals uses CCR5 and/or CXCR4 corecep- tors for cell entry ...variants using CXCR4 exclusively or ... See full document
5
Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.
... Structural studies of recombinant and mutant envelope glycoproteins suggest that the function of the V1/V2 region is to interact with the V3 domain and confer on the envelope gpl20 of HI[r] ... See full document
7
Cooperation of the V1/V2 and V3 Domains of Human Immunodeficiency Virus Type 1 gp120 for Interaction with the CXCR4 Receptor
... the human or rat CXCR4 (31) have been ...D193R human CXCR4 expression vectors (see below) and a vector allowing selection with ...HIV-1 envelope proteins as described previously (42). Viral ... See full document
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Presentation of native epitopes in the V1/V2 and V3 regions of human immunodeficiency virus type 1 gp120 by fusion glycoproteins containing isolated gp120 domains.
... Since the lack of correlation between reactivity of these hemophiliac patient sera with V1/V2 domain peptides by ELISA and with V1/V2 fusion glycoproteins by immunoprecipitation was surp[r] ... See full document
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Independent Evolution of Human Immunodeficiency Virus Type 1 env V1/V2 and V4/V5 Hypervariable Regions during Chronic Infection
... of V1/V2 and V4/V5 population ...either V1/V2 or V4/V5 or both over the course of the study, which were simply defined as replacements in the most abundant HTA variants as measured by ... See full document
5
Rescue of human immunodeficiency virus type 1 matrix protein mutants by envelope glycoproteins with short cytoplasmic domains.
... those associated with wild-type HIV-1 particles. It is possible that the alterations in the MA domain affected determinants that control the normal arrangement of Env protein spikes on the surface of the ... See full document
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Characterization of Stable, Soluble Trimers Containing Complete Ectodomains of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins
... HIV-1 envelope glycoprotein ectodomains to form dimers and ...HIV-1 envelope glycoprotein subunits have been de- vised (20, ...gp160 envelope glycoprotein precursor only when the ... See full document
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Conservation of Human Immunodeficiency Virus Type 1 gp120 Inner-Domain Sequences in Lentivirus and Type A and B Retrovirus Envelope Surface Glycoproteins
... between virus strains as well as different lentiviruses, which resulted in the evolution of viruses with large differences in genome organization and sequence ...the envelope glycoproteins of ... See full document
5
Human Immunodeficiency Virus Type 1 V1-V2 Envelope Loop Sequences Expand and Add Glycosylation Sites over the Course of Infection, and These Modifications Affect Antibody Neutralization Sensitivity
... done using the Wilcoxon matched-pair signed-rank ...FIG. 1. Phylogram of envelope sequences from the nine subjects described here, sequences from other subjects previously isolated in our laboratory, ... See full document
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In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression.
... CD4 1 cell counts were already below 200/ m l, and the patient died of Pneumocystis carinii pneumonia in ...(Table 1), the MDs of V3 were ...of V1 and V2 were 2% in 1992 and 5.1% in 1994. ... See full document
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Determinants of Syncytium Formation in Microglia by Human Immunodeficiency Virus Type 1: Role of the V1/V2 Domains
... of human immunodeficiency virus (HIV) encephalitis, the pathological correlate of HIV dementia (HIVD), a pro- gressive central nervous system (CNS) syndrome induced by HIV-1 infection (27, 43, ... See full document
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Sequence diversity of V1 and V2 domains of gp120 from human immunodeficiency virus type 1: lack of correlation with viral phenotype.
... in human immunodefi- ciency virus type 1 (HIV-1) has been shown for independent viral isolates (1, 42), for sequential isolates from the same patient (15, 18, 41), and within a ... See full document
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Solid-Phase Proteoliposomes Containing Human Immunodeficiency Virus Envelope Glycoproteins
... The human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein gp120 mediates receptor binding and is the major target for neutralizing ...trimeric ... See full document
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Genetic diversity of the highly variable V1 region interferes with Human Immunodeficiency Virus type 1 envelope functionality
... of V1 from cysteine to cysteine (126–157, HXB2 numbering) as we have implemented in our chimeras, leads to the replace- ment of β-sheet A, the V1 loop, and the beginning of β- sheet B (Figure ...the ... See full document
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Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2)
... velope glycoproteins to the evolution of a pathogenic SHIV, an env fragment was cloned from cells infected with the patho- genic SHIV isolate, KU-1 ...Figure 1 shows the predicted amino acid ... See full document
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Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120.
... Syncytium formation induced by CH14 derivatives Clonea pHenv pHenvCH14 pHenvCH14revlC pHenvCH14/418IM pHenvCH14/LIA pHenv/4181M b Relative syncytium Description formation' Wild-type pNL4[r] ... See full document
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Role of Low CD4 Levels in the Influence of Human Immunodeficiency Virus Type 1 Envelope V1 and V2 Regions on Entry and Spread in Macrophages
... strain V1, V2, and V3 regions (designated BBB) in the background of strain NL4-3 (1) and clone 49-5 with the NL4-3 strain V1 and V2 regions, followed by Ba-L sequences from StuI to NheI ... See full document
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The V1, V2, and V3 Regions of the Human Immunodeficiency Virus Type 1 Envelope Differentially Affect the Viral Phenotype in an Isolate-Dependent Manner
... the V2 loop alone from the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) increases the ... See full document
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