[PDF] Top 20 Optimization of solid phase synthesis of quinazolin 4 ones

... Chemistry of quinazolines has been explored from the twilight of the 19 century [1]. Nowadays this scaffold still remains important privileged building block for many biochemical studies. Derivatives of ... See full document

... In conclusion, we have developed an efficient and environmentally benign synthetic method for the synthesis of 2, 3- disubstituted quinazolin-4(3H)-ones from isatoic anhydride, aldehyde and ... See full document

... A mixture of formalin (37-41% ; 1ml) and dimethyl amine (0.005mol) drop by drop with stirring to a slurry of 3-amino-2-butyl-3(H)quinazolin-4-one (0.005 mol) in dimethylformamide (15 ml). The reaction ... See full document

... substituted quinazolin-4(3H)-one ...7-amino- 4-methyl-quinoline-2(1H)-one on the carbonyl carbon of 2-methyl-4H-1,3-benzooxazin-4-one followed by ring opening by the breakage of C-O bond ... See full document

... To a solution of 2-chloro-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide (III) in dry DMF was added substituted heteroaryl amine/thiol slowly with stirring and the reaction mixture was refluxed for 18-24h. The ... See full document

... aromatic primary amine (2-amino-4- phenylthiazole, sulphaguanidine, 2-amino benzthiazole, 2-aminopyridine, sparfloxacin, 2,6- dichloro aniline and hydrazine hydrate) was refluxed for 6 hrs with 10 ml of acetic ... See full document

... potassium hydroxide (0.01mol.) in water (10 ml) were added. The reaction mixture was heated in boiling water bath for 1 hour then left to cool till 20 °C and to this cold solution of the mixture, the appropriate phenacyl ... See full document

... 3-(2-aminoethyl)-2-phenylquinazolin-4(3H)-one (2) was refluxed with various 2-phenyl-4- [(substitutedphenyl)methylidene]-1,3-oxazol-5(4H)-one [13] in dry pyridine for 18-26 hours, the reaction mixture was ... See full document

... Synthesis of 2-phenyl-3-{[1-thiophen-2-ylethylidene]amino}quinazolin-4(3H)-one (16-20). 3-amino-2-substitutedphenylquinazolin-4(3H)-ones (10mmol) was refluxed with 2-acetyl thiophene ... See full document

... The solution phase technique was employed to synthesize the dipeptides. Dipeptides were prepared by coupling Boc-amino acids with the amino acid methyl ester hydrochloride using EDC as coupling agent. All the ... See full document

... ethanol (10 ml) was stirred at ambient temperature for suitable time. After the completion of reaction indicated by Thin Layer Chromatography (TLC), the reaction mixture was diluted with water (15 ml) and extracted with ... See full document

... pyrazolo-[3’,4’-a] quinazolin-4(3H)one (4 a-1 ) was synthesized as follows; To a solution of compound (3 a-1 ) ...separated solid was filtered, recrystallized from DMF to get desired ... See full document

... 2-[2-(2,6-dichlorophenyl)amino]benzyl-3-acetamido-6-iodoquinazolin- 4(3H)one (0.01 moles) 4 in 50ml absolute ethanol, benzaldehyde ...The solid thus obtained was filtered, washed with water and ... See full document

... agents. Quinazolin-4(3H)-ones with substitution at position 3, has been reported to be associated with anti-microbial ...and synthesis of biologically active and pharmacologically important ... See full document

... A new series of 2-(3-oxo-3-phenylpropanoyl)-3-(substituted aryl)-1-thiazolidin-4-ones has been synthesized by cyclocondensation of ketoanils (the condensation products of 2, 4-dioxo-4- phenyl ... See full document

... 2-(1-ethylpropylidene-hydrazino)-3-ethyl- quinazolin-4(3H)-one (S2) emerged as the most active analgesic agent and it is more potent when compared to the reference standard diclofenac ... See full document

... Emission maximum of methoxyphenyl- and thienyl derivatives involving the fluorine atoms at 6 and 7 posi- tions (3c, 5b) is larger then one of non-fluorinated com- pounds 3a, 5a. Incorporation of fluorine atoms does not ... See full document

... Tharabai, M.Pharm., Professor& Head of the Department, Department of Pharmaceutical Chemistry, College of Pharmacy, Madurai Medical College, Madurai-20 CERTIFICATE This is to certify tha[r] ... See full document

... 3-di-substituted quinazolin-4-(3H)-ones (III) have been synthesized as a one pot procedure from the reaction of Anthranilic acid (I), acid chlorides and primary amines with the intermediate ... See full document

... and 4-hydroxy benzaldehyde (1.22 g, 0.01 mol) in 30 ml ethanol with 3–4 drops of piperidine was refluxed for 1 ...The solid separated was filtered, washed with cold ethanol, dried and crystallised ... See full document