[PDF] Top 20 p53: emerging roles in stem cells, development and beyond

... abnormal cells (Vousden and Prives, 2009). Adding complexity to the p53 regulatory network are the potential modulatory roles played by other p53 family members, p63 and p73, that are found in ... See full document

... non-redundant roles in the elaboration of the chambers of the linear heart ...the development and patterning of the non-chamber myocardium of the AVC and in the EMT that is required to form cushion ... See full document

... ES cells, as an excellent model for early development, have provided many novel insights into the developmen- tal roles of ...ES cells only represent a snap- shot of development. ... See full document

... the development of new methods for iPSC generation through the use of integrating and non-integrating recombinant viruses [7–12], DNA ex- pression vectors [13], episomal vectors [14, 15], mini- circle vectors ... See full document

... Three-dimensional nanofiber niche mimicry platforms Various interwoven protein fibers compose the native ECM. Nanofibers with diameters between 50 and 300 nm mimicking the native ECM in size and structure have been ... See full document

... + cells from pre-leukemic Ctsg - PML-RARA mice ...AML development [45]; however, other studies have shown opposite function of Notch signaling in AML (Table ...hematopoietic stem cells (HSCs), ... See full document

... mal development of each ...tumor cells differ from those of c-Myc within a specific cell ...quiescent stem cells, but this expression switches to c-Myc upon differentiation to ... See full document

... to cells and how the dynamics of these anchors are regulated under load remain ...fascicles, cells upregulate MMP2 and MMP13 after very short cycles of loading, but downregulate MMP1 after longer cycles ... See full document

... cancer stem cell, with high-proliferative capacity, self- renewal properties and multi-lineage potential, could be responsible for tumor development and the differentia- tion of more mature epithelial ... See full document

... system development, plasticity and disease (Barres, 2008; Fields et ...during development. We then discuss emerging roles for each glial cell type (astrocytes, oligodendrocytes, Schwann ... See full document

... of cells in extraembryonic membranes, re- duced size, abnormal gastrulation and trophoblast cells, absence of an amnion, and death by embryonic day ... See full document

... immune cells from either innate immunity or adaptive immunity, such as T cells, B cells, DCs, NK cells and ...T cells, MSCs implemented inhibitory function through secreting high levels ... See full document

... tumor cells. Studies have demonstrated that a variety of non-tumor cells in the tumor microenvironment affect tumor behavior; thus, a new focus of cancer research has been the development of novel ... See full document

... Cancer stem cells (CSCs), a small subpopulation of cancer cells, can self-renew, differentiate, and ...tumor development, chemotherapy resistance, metastasis, and recurrence, and are ... See full document

... mES cells was not altered in comparison to that of the control group detected at day 8 after infection by MTT assay ...mES cells were treated with shRNA-Raptor, the cardiomyocyte differentiation efficiency ... See full document

... in p53 mRNA expression levels in the presence or absence of DOXO, indicating posttranscriptional ...of p53-regulated p21 and TP53I3 ...HCT116 cells suggested that HuR directly binds to the ARE at the ... See full document

... of p53 (p53DD) (Shaulian et ...wild-type p53 with p73 (Gaiddon et al., 2001). This form of p53 therefore should specifically inhibit p53 and not ...the cells in these conditions or ... See full document

... precursor cells that also give rise to skeletal muscle (Seale et ...precursor cells by RNAi leads to loss of BAT-specific genes and upregulation of the myocyte (see Glossary, Box 1) program, leading to ... See full document

... of p53 between the senescence and quiescence program in the p53-arrested cells [76, ...the p53-induced quiescence is in fact a result of suppression of senescence by ...cancer cells ... See full document

... Pipepro decided it needed to add a high-tech product to its product portfolio to enhance the national and international image of the company. In the first instance, they invited one of their international partner ... See full document