[PDF] Top 20 PART 2: General methods for Cochrane reviews

... As with any research, the first and most important decision in preparing a systematic review is to determine its focus. This is best done by clearly framing the questions the re- view seeks to answer. Well-formulated ... See full document

... Numerical number 0 = inapplicable Copy the page of recommendation Copy the paragraph of recommendation Copy the recommendation 0 = included 1 = excluded 0 = level of evidence unclear SIG[r] ... See full document

... The production of Cochrane reviews and the subse- quent editorial review process is guided (but not ruled) by the Cochrane Handbook [31]. The overarching principle of the current Handbook (section ... See full document

... Systematic reviews use transparent criteria (such as Grading of Recommendations Assessment, Development and Evaluation (GRADE)) to evaluate the quality of evi- dence 2 and so systematic reviews ... See full document

... that Cochrane reviews and the use of the GRADE approach, but not industry ties, would be associated with the use of com- plete case analysis and judgement of the risk of bias asso- ciated with missing ... See full document

... (table 2). Nearly all Cochrane reviews assessed the method of random sequence generation (100%), concealment of the allocation sequence once randomised (100%), blinding (99%) and incomplete outcome ... See full document

... in reviews are currently generally ...non Cochrane reviews. However all the selected reviews were similar in searches without language restriction and assessment for risk of missing ...non ... See full document

... systematic reviews can provide robust and comparatively inexpen- sive evidence of what is known about intervention effec- tiveness, which may often be more likely to convince decision-makers than evidence from ... See full document

... accuracy of tests. Alternative tests are generally available; hence, it is appropriate to evaluate the accuracy of a test not in isolation, but relative to relevant alternative tests. Unfortunately, studies that directly ... See full document

... the Cochrane Database of Systematic Reviews (CDSR) according to the medical specialty, the types of interventions being compared and the type of ...2321 reviews containing 22,453 meta-analyses, which ... See full document

... the Cochrane risk of bias tool [109] concerning its ease of use and reliability [110,111] and the tool is currently be- ing ...ongoing Cochrane Methods Innovation Fund project will lead to the ... See full document

... systematic reviews reporting adverse drug reactions. In general, systematic reviews reporting adverse drug reactions failed methodo- logically ...systematic reviews reporting oph- thalmic ... See full document

... Systematic reviews are increasingly seen as a key source of information in policymaking, particularly in terms of assisting with descriptions of the impacts of ...Systematic reviews can be undertaken to ... See full document

... In situations where many sources of variation exist between interventions and the contexts in which they are evaluated, meta-analysis, subgroup analysis and meta- regression may identify that different interventions ... See full document

... Results: The search yielded 1666 SRs; 793 met the inclusion criteria. 38% of SRs were last assessed as up-to-date prior to 2007. Corresponding authors were most often from the UK (41%). Most SRs (59%) examined ... See full document

... other methods and tools discussed here it does not yet have sufficient methodological guidance ...the Cochrane Library [40]. These methods and tools were derived from an analysis of those used within ... See full document

... PAFs calculated for the targeted risk factors for Iran and the world are presented in table 2. In Iran, physical inactivity and smoking had the first degree in PAF for AD with 22 and 5%, respectively. The ... See full document

... systematic reviews or IQWiG ...systematic reviews of studies to answer questions about the benefits and harms of medical ...systematic reviews are provided when these are used, but the reviews ... See full document

... Inguinal hernia (IH) in children is a congenital lesion resulting from a persistent patent processus vaginalis (PPV) [1]. The reported incidence of IH varies from 3% to 5% in full-term newborns, 13% among newborns born ... See full document

... Surgery aims at draining multiple localized abscesses or treating a diffuse peritonitis (from severe abdominal sepsis or active bleeding) [2]. However, authors recom- mended to avoid surgery on fistulas occurring ... See full document