[PDF] Top 20 1 Pathogen at the Gates: HCMV Entry and Cell
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1 Pathogen at the Gates: HCMV Entry and Cell
... membrane fusion may explain why the trimer is required for the infectivity of cell-free virions in cellsA. 112.[r] ... See full document
13
Pathogen at the Gates: Human Cytomegalovirus Entry and Cell Tropism
... of cell types and tissues that the virus ...govern HCMV cell tropism, while CD90 and CD147 were also found to play roles during ...of cell-associated spread that resists antibody ... See full document
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Herpesvirus Entry Mediator on Radiation Resistant Cell Lineages Promotes Ocular Herpes Simplex Virus 1 Pathogenesis in an Entry Independent Manner
... T cell reactivity (59), we began by comparing mock-infected WT and HVEM KO corneas to rule out any differ- ences between the genotypes unrelated to HSV-1 ...T cell chemoat- tractant CXCL10 ... See full document
13
Wu, Yi-Quan (2017): The role of the cytomegalovirus glycoprotein complex gHgLgO in virus entry. Dissertation, LMU München: Medizinische Fakultät
... of HCMV occurs through different routes, either horizontally via direct contact with infected individuals who excrete infectious virus in their bodily secretions including respiratory droplets, blood, urine and ... See full document
107
Expression of Oncogenic Alleles Induces Multiple Blocks to Human Cytomegalovirus Infection
... limit HCMV repli- cation, we employed a genetically defined model of tumorigenesis, which consists of primary human foreskin fibroblasts, life-ex- tended telomerase-expressing fibroblasts, and life-extended fibro- ... See full document
11
Host pathogen reorganisation during host cell entry by Chlamydia trachomatis
... at entry sites, which have been observed by live fluorescence microscopy and scanning elec- tron microscopy ...at entry sites, the degree of actin recruitment was unexpectedly not as extensive as that in ... See full document
6
Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry
... the cell surface, consisting of a transmembrane protein linked to sulfated glycosaminoglycans ...the cell membrane barrier, using them for initial cell attachment or as entry ... See full document
8
Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes
... primary HCMV infection, circulating blood monocytes mediate the systemic spread of the ...that HCMV glycoprotein gB binding to cellular epidermal growth factor receptor (EGFR) during HCMV ... See full document
10
Human Cytomegalovirus Modulates Monocyte-Mediated Innate Immune Responses during Short-Term Experimental Latency In Vitro
... Latent HCMV modulates interferon signaling in CD14 ⴙ ...by HCMV presents a signifi- cant biological challenge to the ...by HCMV induces expression of cellular transcripts associated with antiviral ... See full document
15
Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium
... of cell divisions and cell fate, we demonstrate that: (1) the control of NSC proliferation by Notch primarily targets cell cycle re-entry from quiescence, and thus NSC activation, and ... See full document
13
Host pathogen reorganisation during host cell entry by Chlamydia trachomatis
... at entry sites, which have been observed by live fluorescence microscopy and scanning electron microscopy ...at entry sites, the degree of actin recruitment was unexpectedly not as extensive as that in ... See full document
15
Ischaemic stroke and Clostridium septicum sepsis and meningitis in a patient with occult colon carcinoma - a case report and review of the literature
... Therefore the antibiotic therapy was escalated with vanco- mycin. On the following day anaerobic blood cultures grew also Gram-positive rods with some of them showing endospore formation (Fig. 2b). Aerobic blood cultures ... See full document
6
Preventing HIV infection without targeting the virus: how reducing HIV target cells at the genital tract is a new approach to HIV prevention
... HESNs in this Nairobi cohort have reduced gene expression in the T cell receptor-signalling pathway, which is crucial to T cell activation [25, 26]. Furthermore, non-stimulated peripheral blood mononuclear ... See full document
5
Amino Acid Changes within Conserved Region III of the Herpes Simplex Virus and Human Cytomegalovirus DNA Polymerases Confer Resistance to 4-Oxo-Dihydroquinolines, a Novel Class of Herpesvirus Antiviral Agents
... 40 HCMV clinical isolates (7) demonstrated that the valine at amino acid 823 was present in the DNA polymerases of all of these ...and HCMV and the drop in antiviral activity against the V823A HSV-1 ... See full document
9
Human Cytomegalovirus Inhibits Transcription of the CC Chemokine MCP-1 Gene
... through a negative feedback loop. To determine whether the US28-encoded chemokine receptor is involved in the ob- served regulation of MCP-1 mRNA expression, we con- structed a mutant virus that could not express ... See full document
7
Antigenic Domain 1 Is Required for Oligomerization of Human Cytomegalovirus Glycoprotein B
... Studies of other type I viral glycoproteins have demon- strated the domains within the ectodomain of the TM compo- nent (lumenal domains) are essential for multimerization of monomeric forms of this glycoprotein through ... See full document
14
Capsid Structure of Kaposi's Sarcoma-Associated Herpesvirus, a Gammaherpesvirus, Compared to Those of an Alphaherpesvirus, Herpes Simplex Virus Type 1, and a Betaherpesvirus, Cytomegalovirus
... connected densities of about the right size for a protein of 10 to 20 kDa, overlying the positions of both the hexon and the penton subunits. Since similar densities are seen in all quasiequivalent sites, including those ... See full document
12
Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter
... an HCMV tegument ...novo HCMV gene expression but does not affect the abun- dance of tegument proteins, as confirmed by the detection of IE1 and pp65, respec- tively ... See full document
21
Viral Regulation of RANTES Expression during Human Cytomegalovirus Infection of Endothelial Cells
... allow HCMV to establish latency in the ...of HCMV infection and may also be a site of latent HCMV ...that HCMV down-regulates expression of the proinflammatory chemokine RANTES from the ... See full document
8
Inhibition of Cell Division by the Human Cytomegalovirus IE86 Protein: Role of the p53 Pathway or Cyclin-Dependent Kinase 1/Cyclin B1
... the HCMV IE86 pro- tein (Ad-IE86) were described previously ...per cell in a serum-free medium containing 3 l of Lipofectamine reagent (Life Technologies, Gaithersburg, ...After 1 h at 37°C, the ... See full document
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