[PDF] Top 20 Pathogenesis of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesions in B-Cell-Deficient Mice
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Pathogenesis of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesions in B-Cell-Deficient Mice
... for B-cell-mediated immunity in HSK ...from lesions if it is present in sufficient concentrations soon after infection (9, 22, 28, ...Furthermore, B cells may be important during the clinical ... See full document
8
Scrapie Pathogenesis in Subclinically Infected B-Cell-Deficient Mice
... 14 mice (13 to 65% within a confidence interval of 95%) tested positive by either Western blot analysis, infectivity bioassay, or both ...in B-cell-deficient mice (n ⫽ 27), even 665 ... See full document
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In Vitro-Generated Antigen-Specific CD4+ CD25+ Foxp3+ Regulatory T Cells Control the Severity of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesions
... the pathogenesis of a virus-induced immunoinflammatory le- ...that lesions caused by HSV infection in the eye were more severe in animals depleted of nTregs (29), so it was anticipated ... See full document
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Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice
... promotes ocular HSV-1 pathogenesis independently of viral entry receptor functions (16, ...following ocular challenge of HSV-1, which is critical for the development of HSK ...(8). Mice ... See full document
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Herpesvirus Entry Mediator on Radiation Resistant Cell Lineages Promotes Ocular Herpes Simplex Virus 1 Pathogenesis in an Entry Independent Manner
... T cell infiltrates; and (iii) lack of HVEM expression on radiation-resistant cell types is sufficient to protect against wild-type-like ...WT mice were also more heavily infiltrated by CD3 ⫹ T cells ... See full document
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Protective Mucosal Immunity to Ocular Herpes Simplex Virus Type 1 Infection in Mice by Using Escherichia coli Heat-Labile Enterotoxin B Subunit as an Adjuvant
... the virus within the TG was ...in mice immunized with Ctx-CtxB as an adjuvant (27). The ability of virus to establish latency in mice immunized in the presence of rEtxB may be the result of ... See full document
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Viral replication is required for induction of ocular immunopathology by herpes simplex virus.
... with herpes simplex virus ...latent virus from the trigeminal ganglion ...SCID mice unless the mice are reconstituted with T cells of the CD4 1 phenotype (1, 22, ...disease ... See full document
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Herpes Simplex Virus-Induced Keratitis: Evaluation of the Role of Molecular Mimicry in Lesion Pathogenesis
... HSK pathogenesis it should be a potent immunogen when the virus was used for ...in mice infected with HSV, although weak though undetectable responses remain a ...peptide-immunized mice, ... See full document
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Susceptibility of CCR5-Deficient Mice to Genital Herpes Simplex Virus Type 2 Is Linked to NK Cell Mobilization
... and B cells between the vaginal epithelium and the draining (iliac) lymph nodes during genital HSV-2 infection have been described previously ...NK cell re- cruitment and activity at the site of infection ... See full document
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Persistence of Herpes Simplex Virus Type 1 DNA in Chronic Conjunctival and Eyelid Lesions of Mice
... Herpes simplex virus type 1 (HSV-1) causes a number of important diseases in humans, including chronic ocular disease ...best-studied ocular disease induced by HSV (11), chronic ... See full document
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Pathogenesis of Herpes Simplex Virus Type 1-Induced Corneal Inflammation in Perforin-Deficient Mice
... the pathogenesis of HSK has been previously demonstrated in a MIP-1␣-deficient mouse model ...PKO mice was reflected by differences in the presence of MIP-1␣ in the ...PKO mice in our studies ... See full document
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TNFRSF25 Agonistic Antibody and Galectin-9 Combination Therapy Controls Herpes Simplex Virus-Induced Immunoinflammatory Lesions
... of virus spreading to the cornea after being reactivated from latency in nerve ganglia ...or virus specific ...T cell function represent logical approaches to ...in mice ocularly infected with ... See full document
15
Protective T-Cell-Based Immunity Induced in Neonatal Mice by a Single Replicative Cycle of Herpes Simplex Virus
... Sendai virus vaccines (55) but not with live attenuated measles virus ...Sindbis virus-based vectors containing gB (19) failed (data not ...of virus able to replicate in neonates until ... See full document
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Fusion-Deficient Insertion Mutants of Herpes Simplex Virus Type 1 Glycoprotein B Adopt the Trimeric Postfusion Conformation
... Figure 6 shows representative proteolytic patterns generated by limited digestion of gB730, T665i5, V667i5, I671i5, L673i5, and E187i5 with chymotrypsin. T665i5, V667i5, I671i5, and L673i5 were digested into fragments ... See full document
12
Herpes Simplex Virus Type 2-Induced Mortality following Genital Infection Is Blocked by Anti-Tumor Necrosis Factor Alpha Antibody in CXCL10-Deficient Mice
... ⫺/⫺ mice treated with anti-TNF- ␣ Ab, expression of CCL2, CXCL1, and CXCL9 in the CNSs of the infected mice was assessed as a means to identify a possible scenario responsible for the dramatic change in ... See full document
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Production of soluble suppressor factors by herpes simplex virus-stimulated splenocytes from herpes simplex virus-immune mice.
... In the present report we provide direct evidence that induction of in vitro HSV-specific CTL is regulated by soluble suppressor factors produced by HSV-specific T lymphocytes HSV-SF.. HS[r] ... See full document
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Physical mapping of herpes simplex virus-induced polypeptides.
... The previously undescribed recombinants B x 5 7, B x 5 10, B x 6 17, 17+ x llr 1, and F x 5 12 were generated and plaque purified by the Downloaded from http://jvi.asm.org/ on November 1[r] ... See full document
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Protection of mice from herpes simplex virus-induced retinitis by in vitro-activated immune cells.
... ATHERTON* Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida 33136 Received 3 May 1989/Accepted 1 August 1989 Inoculation of 2 x 104 PFU of[r] ... See full document
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Identification of a common antigen of herpes simplex virus bovine herpes mammillitis virus, and B virus.
... Of the additional polypep- to BHM virus per cm2; E 15 ,ul of [35SJmethioninetides present in the individual antigens Table labeled HSV-2 antigen precipitated in gel containing 1, the pol[r] ... See full document
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Altering the Expression Kinetics of VP5 Results in Altered Virulence and Pathogenesis of Herpes Simplex Virus Type 1 in Mice
... The fact that altering the expression of a structural protein like VP5 could have an impact on neuronal replication is intriguing, but not without precedent. Desai et al. demon- strated that null mutants of VP26, the ... See full document
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