[PDF] Top 20 Pattern Recognition Receptor MDA5 Modulates CD8+ T Cell-Dependent Clearance of West Nile Virus from the Central Nervous System
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Pattern Recognition Receptor MDA5 Modulates CD8+ T Cell-Dependent Clearance of West Nile Virus from the Central Nervous System
... and MDA5, have been implicated in host control of virus infection, the relative role of each RLR in restricting pathogenesis in vivo remains ...adaptor central to RLR signaling, is required to ... See full document
15
The Bacteriostatic Protein Lipocalin 2 Is Induced in the Central Nervous System of Mice with West Nile Virus Encephalitis
... the central nervous system (CNS) of mice during West Nile virus (WNV) ...toll-like receptor 3 (TLR3) gene, retinoic acid-inducible gene 1 (RIG-I), and melanoma ... See full document
11
The Innate Immune Adaptor Molecule MyD88 Restricts West Nile Virus Replication and Spread in Neurons of the Central Nervous System
... after recognition by cytoplasmic or endosomal RNA sensors (RIG-I-like RNA helicases [RLR] and Toll-like receptors [TLR]), which signal through the cognate adaptor signaling molecules IPS-1, TRIF, and ...RLR ... See full document
14
CD4+ T-Cell Responses Are Required for Clearance of West Nile Virus from the Central Nervous System
... ⫹ T lymphocytes are believed to control viral infection through several mechanisms, including activation and priming of B- and T-cell responses, production of inflamma- tory and antiviral cytokines, ... See full document
10
Fas Ligand Interactions Contribute to CD8+ T-Cell-Mediated Control of West Nile Virus Infection in the Central Nervous System
... that CD8 ⫹ T cells utilize per- forin to clear WNV from infected neurons (41, ...and CD8 ⫺/⫺ mice were distinct, and thus, additional CD8 ⫹ T-cell-dependent ... See full document
9
ICAM-1 Participates in the Entry of West Nile Virus into the Central Nervous System
... how West Nile virus crosses the blood-brain barrier is critical to understanding the pathogen- esis of ...lethal West Nile ...in West Nile virus neuroinvasion and ... See full document
5
CXCR3 Mediates Region-Specific Antiviral T Cell Trafficking within the Central Nervous System during West Nile Virus Encephalitis
... by West Nile virus (WNV)-infected neurons is essential for the recruitment of CD8 T cells for the purpose of viral clearance within the ...CXCL10 receptor, CXCR3, to ... See full document
10
CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system
... that clearance of virus is associ- ated with prompt resolution of encephalitis, with decreased numbers of infiltrating T cells ...parenchymal T cells and low levels of WNV antigen at day 8 ... See full document
8
Neuronal CXCL10 Directs CD8+ T-Cell Recruitment and Control of West Nile Virus Encephalitis
... antigen-specific CD8 ⴙ T cells into the central nervous system is an essential step towards clearance of West Nile virus (WNV) from infected ...of ... See full document
10
Role of CD8+ T Cells in Control of West Nile Virus Infection
... with West Nile virus (WNV) causes fatal encephalitis more frequently in immunocompromised humans than in those with a healthy immune ...the central nervous ...of CD8 ⴙ T ... See full document
10
CD8+ T Cells Require Perforin To Clear West Nile Virus from Infected Neurons
... that CD8 ⫹ T cells have an essential role in eradicating WNV from infected tissues in the periphery and CNS (55, ...of clearance remained uncertain as CD8 ⫹ T cells may use ... See full document
11
CD8+ T Cells Mediate Recovery and Immunopathology in West Nile Virus Encephalitis
... of West Nile virus (WNV) develop a characteristic central nervous system (CNS) disease, including an acute inflammatory ...and virus could be detected in the CNS 7 days ... See full document
12
CD8+ T Cells Use TRAIL To Restrict West Nile Virus Pathogenesis by Controlling Infection in Neurons
... control West Nile virus (WNV) infection in peripheral and central nervous system (CNS) ...dengue virus, a closely related flavivirus, in cell ...viral ... See full document
12
The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection
... c Virus recognition and response by the innate immune system are critical components of host defense against ...of cell-intrinsic immunity and optimal priming of adaptive immunity against ... See full document
10
Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance
... NK T cells, and CD8 ⫹ T cells, can produce IL-17A (23, ...IL-17A receptor (IL-17R) is expressed ubiquitously in virtually all cell types and tissues examined (67, 68, ...Although ... See full document
22
T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system.
... To determine whether cell-mediated immunity might contribute to the reduction in viral titer in the CNS, spleen cells from mice immunized 6 days previously with JHMV were adoptively tran[r] ... See full document
6
Central Nervous System Pathology Caused by Autoreactive CD8+ T-Cell Clones following Virus Infection
... encephalomyelitis virus (TMEV) causes a demyelinating disease in infected mice which has similarities to multiple ...cells from TMEV-infected SJL/J mice stimulated with antigen- presenting cells infected ... See full document
7
Receptor Utilization and Antiviral CD8 T Cell Responses during Central Nervous System Infection with a Murine Coronavirus
... modulate CD8 T cell differentiation in the brain during MHV-GP33 infection, resulting in the modest defects in cytokine expression and upregulation of PD-1 ...the pattern of virus ... See full document
171
Dynamics of Tissue-Specific CD8+ T Cell Responses during West Nile Virus Infection
... IMPORTANCE West Nile Virus (WNV) is the leading cause of mosquito-borne en- cephalitis ...infection. CD8 ⫹ T cells are critical for con- trolling WNV replication and protecting against ... See full document
16
Collaboration of Antibody and Inflammation in Clearance of Rabies Virus from the Central Nervous System
... rabies virus CVS-F3 leads to replication of the virus in the CNS which is accompanied by signs of mild disease even in fully immunocompetent ...infectious virus, viral antigen, and viral RNA could be ... See full document
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