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Perturbation of the p53 response by human papillomavirus type 16 E7.
... of E7-associ- ated kinase complexes from E7-expressing RKO cells showed that, in contrast to cyclin-associated kinase activities, the E7- associated kinase activity was not significantly ... See full document
9
Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene.
... The human papillomavirus type 16 (HPV-16) genome is commonly present in human cervical carcinoma, in which a subset of the viral genes, E6 and E7, are ...and E7 ... See full document
14
Different Methods of Identifying New Antigenic Epitopes of Human Papillomavirus Type 16 E6 and E7 Proteins
... man papillomavirus (HPV) infection and the development of squamous intraepithelial lesions (SIL) is well described, the exact mechanisms that lead from HPV infection to cancer are not well ...immune ... See full document
8
Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation.
... in response to TGF- b ...a p53-independent manner ...HPV E7 have been shown to overcome TGF- b ...of p53 in differentiating keratinocytes ... See full document
8
Anchorage-Independent Transcription of the Cyclin A Gene Induced by the E7 Oncoprotein of Human Papillomavirus Type 16
... that E7-dependent transactivation of the cyclin A promoter is reduced by about 50% in response to coexpression of a dominant negative mutant of cdk2 (56a, ...separate E7- dependent processes driving ... See full document
12
Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53 binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus induced DNA damage response
... cellular response to DNA damage, localizes to HPV rep- lication compartments, inside nuclear foci, whose size directly increases together with virus productive replica- tion ...particular E7 promotes DNA ... See full document
13
The Human Papillomavirus Type 16 E7 Oncogene Is Required for the Productive Stage of the Viral Life Cycle
... pol␣), p53, mdm2, and p21 immunohistochemistry was performed under the following con- ...anti-human p53 (clone DO-1) was used at a dilution of 1:1,000, all for 3 ... See full document
10
Human Papillomavirus Type 16 E6/E7 Upregulation of Nucleophosmin Is Important for Proliferation and Inhibition of Differentiation
... ulate p53- and pRb-associated growth arrest functions (18, ...of p53 (19) as well as interact with pRb (23, ...of p53 and ...regulated p53, and caused reduced proliferation rates in a number ... See full document
9
Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Centrosomal Component γ-Tubulin
... and E7 oncoproteins, and the deregulated expression of these proteins is necessary for the initiation and mainte- nance of the transformed phenotype (reviewed in reference ...and E7 proteins interfere with ... See full document
11
p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein
... HPV 16 E2 protein can induce apoptosis in HPV- transformed cells via the regulation of E6/E7 expression and via a direct interaction with ...wild type E2 protein or one of the E2 mutants and a ... See full document
9
The Tumor Suppressor Protein P53 and the Antagonizing Oncoprotein E6 from Human Papillomavirus Type 16
... First, p53 response elements are varied across the genome due to different base-pair spacing between half sites and response elements which fulfill the consensus sequence requirement (El-Diery et al, ... See full document
204
Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7
... of E7-induced pRB degradation? At this point we have not yet identified the factor(s) that is in- volved, but our studies have started to illuminate this ...that E7 induces pRB degradation through an ... See full document
9
Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16.
... and E7-encoded antigens in the Tg mice is ...the E7 gene in the epidermis may be too low to induce an immune response and even too low to render the epidermis as sensitive CTL targets in ...CTL ... See full document
7
Regulation of Human Papillomavirus Type 16 E7 Activity through Direct Protein Interaction with the E2 Transcriptional Activator
... relocalizes E7, but not E6, to mitotic chromosomes at ...of E7 by E2 is a highly specific ...an E7 mutant form that fails to bind E2, which likewise also failed to colocalize with E2 on mitotic ... See full document
11
Genetic variability in E6 and E7 oncogenes of human papillomavirus Type 16 from Congolese cervical cancer isolates
... At the E6 genomic region, five characteristic muta- tions, C143G, G145T, T286A, A289G, and C335T defin- ing the African lineage were found in our study as well as it’s was previously described [8,11,24]. However, some of ... See full document
7
The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19ARF
... expressing E7 but not E6, the levels of pRb protein are reduced while the levels of p53 are increased (13, ...that E7 stimulates the transition into S phase; however, the increase in the amount of ... See full document
9
Myc and Human Papillomavirus Type 16 E7 Genes Cooperate To Immortalize Human Keratinocytes
... ⫹ E7 cells contained high levels of p53 protein, there are compensatory cellular mecha- nisms that can functionally inactivate p53 transcriptional activ- ity and permit continued cell ... See full document
7
Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein.
... the E7-expressing clones, consistent with the FACS analysis data, verifying that the cells were continuing to ...in E7-expressing cells. No difference in mRNA levels was seen in the E7-expressing ... See full document
8
Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.
... p53 immunoprecipitations from the rare colonies of cells arising following transfection with pE7 plus ras plus wild-type p53 or Ela plus ras plus wild-type p53 show that the level of p53[r] ... See full document
6
Human Papillomavirus E7 Induces Rereplication in Response to DNA Damage
... in E7-expressing RPE1 ...in E7-expressing cells is longer than that in the vector- containing cells (⬃3 h versus ⬃1 h) ...in E7-expressing cells did not change significantly ...in ... See full document
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