[PDF] Top 20 Phorbol esters modulate the phosphorylation of human T-cell leukemia virus type I Tax.
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Phorbol esters modulate the phosphorylation of human T-cell leukemia virus type I Tax.
... 4436 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest The Tax protein from human T-cell leukemia virus type I HTLV-I is a 40-kDa phosphoprotein capable of activating tran[r] ... See full document
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Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathy.
... form I, II, and III DNA. Jurkat T cells were transfected by the DEAE-dextran method with 5 to 10 m g of the indicated ZipNeoSV(X)1-tax construct and 2 m g of reporter plasmid ...and cell ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Dysregulates β-Catenin Signaling
... transformed T-cell lines and that Tax activates Akt in these cells ...HTLV-1-infected T-cell lines, we examined the phosphorylation status of Akt and the in vitro Akt kinase ... See full document
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Characterization of an infectious molecular clone of human T-cell leukemia virus type I.
... tion, cell-associated viral protein expression, and analyses of supernatants for complete virus ...K30 cell line, consistent with a new integration event ...the tax probe, but not the env ... See full document
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Role of protein kinase A in tax transactivation of the human T-cell leukemia virus type I long terminal repeat.
... To further substantiate the critical role of PKA in HTLV-I LTR induction by cyclic AMP and to determine if the decrease in transactivation by tax seen in the kinase-deficient cells would[r] ... See full document
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Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells.
... above I k B a was detected immediately after PMA addition to MT-2 cells ...of I k B a phosphorylation in MT-2 cells ...increased I k B a levels and also in- creased the amount of the putative ... See full document
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The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.
... Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are oncogenic retroviruses associated with human T-cell malignancies and degenerative ... See full document
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Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activator tax.
... T C GT A A among -179 to -159 -35 to -55 A cCC C G G T T AA to 48 -48 to -68 -39 to -59 68 the TREs, CREs, and the 5'-CCCACAGTCCCCCGTGACGTCACCCGGGAGCCCGGGGGATCC-3' 3'-CCTAGGGGGTGTCAGGGGG[r] ... See full document
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Influence of human T-cell leukemia virus type I tax and rex on interleukin-2 gene expression.
... 67, 1993 HTLV-I tax AND rex INFLUENCE ON IL-2 GENE EXPRESSION structs also confirm this observation, because expression of tax and rex in those experiments is promoted by the HTLV-I DISC[r] ... See full document
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Mutational analysis of human T-cell leukemia virus type 2 Tax.
... Several Tax-2 mutants, including three of the four truncation mutants (F4Term, Y70Term, and Y157Term) and point mutants T113-A and S258-A, lost all transactivation capacity (Table ...that Tax-2 mutant ... See full document
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Human T cell leukemia virus type I (HTLV I) infection and the onset of adult T cell leukemia (ATL)
... as T-lym- phocytes, B-lymphocytes, monocytes and fibroblasts ...on cell surfaces [47]. However, the HTLV-I pro- virus is mainly detected in CD4-positive lymphocytes, with about 10% in ... See full document
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Phosphorylation of Two Serine Residues Regulates Human T-Cell Leukemia Virus Type 2 Rex Function
... Human T-cell leukemia virus (HTLV) types 1 (HTLV-1) and 2 (HTLV-2) are complex retroviruses that have been caus- ally associated with leukemia and neurological disorders in ... See full document
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Target epitope in the Tax protein of human T-cell leukemia virus type I recognized by class I major histocompatibility complex-restricted cytotoxic T cells.
... 2928-2933 0022-538X/92/052928-06$02.00/0 Copyright © 1992, American Society for Microbiology Target Epitope in the Tax Protein of Human T-Cell Leukemia Virus Type I Recognized by Class I[r] ... See full document
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Silencing of human T cell leukemia virus type I gene transcription by epigenetic mechanisms
... and tax gene transcription was analyzed ...of tax gene transcripts (Case 1, 9, 12, 20), 5'-LTR was not methylated or slightly ...of tax gene is asso- ciated with unmethyalted or slightly methylated ... See full document
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Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins.
... All constructs containing the HIV-1 direct repeats proved inducible in the Jurkat tax-9 cell line but not in the Jurkat anti-tax-10 cell line, suggesting that the observed induction of t[r] ... See full document
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Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax.
... the tax gene of human T-cell leukemia virus type I (HTLV-I), although the sequence variation between patients is small compared with that of human ... See full document
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Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Modulates Its Activity
... tein Tax serves an important role for the initial transformation of T cells (54, 59, 67), but long-term adult T-cell leukemia cells are paradoxically lost for Tax expression (35, ... See full document
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Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein.
... The transactivator Tax from human T-cell leukemia virus type I HTLV-I 7, 22, 32, the X protein from hepatitis B virus 38, 47, 48, and the IEl protein from cytomegalovirus CMV 34 have bee[r] ... See full document
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The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein.
... Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.. Adult T-cell leukemia antigen in an ATL cell line and[r] ... See full document
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Expression and characterization of the trans-activating protein Tax of human T-cell leukemia virus type I in Saccharomyces cerevisiae.
... To test the ability of the Tax protein to trans activate the HTLV-I enhancer in yeast cells, the pX region of HITLV-I, encoding the Tax protein, was cloned under the control of the yeast[r] ... See full document
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