[PDF] Top 20 Phosphorylation of Transcription Factor Sp1 during Herpes Simplex Virus Type 1 Infection

... cases phosphorylation of Sp1 results in a change in its DNA binding affinity (2, 20, 33, ...infected-cell Sp1 and uninfected-cell Sp1 to bind to DNA in mobility shift ...baculovirus-produced ... See full document

... viral infection. It has been previously reported that herpes simplex virus type 1 (HSV-1) infection induces activation of protein kinase activity of ATM and ... See full document

... The ICP22/UL13 double-mutant d22/13 was constructed by using a marker transfer protocol (54), as follows. First, an ICP22 deletion virus, designated d22, was constructed. This mutant contains the same ICP22 gene ... See full document

... phosphorylated during HSV-1 ...cell. During stress, the stress-activated kinase p38 phosphorylates Hsp27 on any of three serines (Ser15, Ser78, and/or Ser82) and this phosphorylation triggers ... See full document

... of infection (MOI) for lytic growth in cultured cells (reviewed in reference ...cellular transcription factors such as Sp1 (re- viewed in reference ...why transcription occurs efficiently on ... See full document

... of infection in the cell, the tegument proteins which dissociated upon virion entry must associate to create the tegument of new ...The phosphorylation of VP1/2, VP13/14, VP16, and VP22 has been ... See full document

... rRNA transcription, process- ing, and assembly into the ribosomal ...of infection, like viral DNA replication, virus assembly, and control of intracellular trafficking (for reviews see references 22 ... See full document

... in herpes simplex virus type 1 (HSV-1) ...of infection in mice, HSV-1 replication in trigeminal ganglia and brain stem tissue was modestly but consistently enhanced ... See full document

... MILLETTE* Department of Biology, Portland State University, and Department of Microbiology and Immunology, Oregon Health Sciences University, Portland, Oregon 97207 Received 18 February [r] ... See full document

... through phosphorylation. As noted in the introduc- tion, phosphorylation of a serine-rich region of ICP4 from residues 140 to 210 by protein kinase A appears to be required for efficient HSV replication in ... See full document

... facilitate transcription. In this report we use lytic infection by herpes simplex virus type 1 (HSV-1) as a model to examine the temporal profile of histone H3 ... See full document

... that phosphorylation at sites in the C-ter- minal half of ICP27 targets the protein for early degradation, similar to the situation that occurs with ...tion factor NF-kB is sequestered in the cytoplasm by ... See full document

... lytic infection by herpes simplex virus type 1 (HSV-1), histones are present at relatively low levels on the viral ...when transcription of the viral ... See full document

... wild-type virus, the HSV-1 genome’s lytic gene promot- ers become associated with dimethyl histone H3 K9, a marker of transcriptional repression, during establishment of latency, while they ... See full document

... steps during the entry process could be effected. In MDCKII cells, virus internalization is not blocked by active Rac1 and Cdc42, and capsids seem to accumulate at the nu- cleus, suggesting that further ... See full document

... fragment 1; BGLF5: BamHI G leftward frame 5; BHRF1: BamHI fragment H rightward open reading frame 1; BNLF2a: BamHI-N leftward frame 2a; BZLF1: BamHI Z fragment leftward open reading frame 1; CCR5: ... See full document

... disassemble during mitosis and apoptosis and are structurally affected by many forms of stress, such as heat shock, heavy metal treat- ment, and a variety of drugs that alter cellular ...gene transcription ... See full document

... for Sp1 contact and ones that repress HIV-1 replication in cultured T cells ...(Fig. 1 and ...and Sp1 proteins ...phosphorylated Sp1 for Tat transactivation ac- ...of ... See full document

... viruses. During the past few years, pharmacological CDK in- hibitors have been used effectively to inhibit the replication of human cytomegalovirus, herpes simplex virus, and HIV (6, 8, 45, ... See full document

... On the other hand, the hypothesis that DNA binding is not important for transactivation by ICP4 is supported by the observation that certain temperature-sensitive mutants appear to have [r] ... See full document