[PDF] Top 20 PI3K mutations in breast cancer: prognostic and therapeutic implications
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PI3K mutations in breast cancer: prognostic and therapeutic implications
... of PI3K mutations, some of which asked if they have prognostic or predictive value, or ...both. Prognostic and predictive factors are often ...a prognostic biomarker is a marker that ... See full document
13
Identification of three subtypes of triple negative breast cancer with potential therapeutic implications
... of breast cancer tumors. Twelve GES were used for breast cancer molecular subtyping: 4-TNBC, androgen receptor (AR), basal-like, tumor identity card (CIT), claudin-CD24, claudin-low, ER, ... See full document
14
Original Article PIK3CA mutations and downstream effector p-mTOR expression: implication for prognostic factors and therapeutic targets in triple negative breast cancer
... PIK3CA mutations and phosphorylated mTOR (p-mTOR) expression are two main events on PI3K/Akt/mTOR pathway, limited data has reported their roles in triple negative breast cancer ...cohort, ... See full document
10
Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms
... ATM mutations have a twofold higher breast cancer ...ATM mutations are likely linked to an increased level of sensitivity to platinum-based antineoplastic drugs [110, ...of cancer ... See full document
25
<p>The distinct clinicopathological and prognostic implications of <em>PIK3CA</em> mutations in breast cancer patients from Central China</p>
... primary breast tumor tissue samples were collected at the Department of Pathology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China from ... See full document
20
Prognostic implications of immunohistochemically detected YKL 40 expression in breast cancer
... Breast cancer afflicts approximately 200,000 women per year in the United States and is the second leading cause of cancer death in this country ...have prognostic import, although they are ... See full document
7
Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression
... the PI3K/Akt pathway is linked to the development of cancer and the inhibition of this pathway has been shown to facilitate apoptosis and to sensitize cells to cytotoxic drugs in experimental studies [3, ... See full document
21
Prognostic Implications of Claudin 4 and Rock 1 in Triple Negative Breast Cancer
... potential therapeutic target in human breast cancer, with the possible use of ROCK inhibitors acting as antimetastatic chemotherapeutic agents ... See full document
9
Mutations in the phosphatidylinositol 3 kinase pathway: role in tumor progression and therapeutic implications in breast cancer
... of breast cancers. Clinical and experimental evidence suggest that PI3K pathway activation promotes resistance to some of the current breast cancer ...therapies. PI3K is a major ... See full document
12
Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression
... ER/PR breast cancer patients, acquired or de novo resistance and subsequent recurrence remain significant clinical ...and PI3K/Akt/mTOR inhibitors in neoadjuvant settings is necessary to break down ... See full document
17
Pi3k Signaling Pathway and Pten in Triple Negative Breast Cancer
... since breast cancer is a very heterogeneous ...PIK3CA mutations are more sensitive to inhibitors of the PI3K pathway but this has yet to be ... See full document
29
Actualities on diagnosis, targeting and treating bone metastases in breast cancer with radiotherapy and new drugs
... disease presentation. Other conditions in which biopsy can be mandatory are necessities of differential diagnosis. The differential diagnosis for bone metastases includes chondrosarcoma, primary malignant lymphoma of the ... See full document
23
Prognostic effect of pregnancy on young female patients with nasopharyngeal carcinoma: results from a matched cohort analysis
... of breast cancer, a worse survival outcome may be predicted. Breast cancer, which was frequently diagnosed during pregnancy, has two findings in recent years: pregnancy was a protective factor ... See full document
9
Impact of prognostic nutritional index on long term outcomes in patients with breast cancer
... There are several known predictors of breast cancer prognosis, such as tumor size, histological type, lymph node involvement, hormonal receptor status, and HER2 status. However, it is of interest that there ... See full document
5
Emerging Diagnostic and Prognostic Biomarkers of Triple Negative Breast Cancer
... in breast cancer for almost 10 ...in breast cancer appears to reside in the sequences and framework of the hMAG-lipophilin ...the breast cancer cases, independent of stage and ... See full document
5
mTOR pathway in colorectal cancer: an update
... subsequent PI3K activation and re- phosphorylation of Akt Thr308 sufficient to reactivate Akt activity and ...that PI3K is activated in response to mTOR inhibition in these cells ...of PI3K. Thus ... See full document
18
An anti-ErbB2 fully human antibody circumvents trastuzumab resistance
... We used flow cytometry to determine the apoptosis- inducing activity of H2-18 in BT-474, SKBR-3, HCC-1954, HCC-1419 cell lines by using Dead Cell Apoptosis Kit. In H2-18-treated HCC-1954 cells, the percentage of Annexin ... See full document
13
Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway
... the breast cancer cells were seeded into six-well plates at a density of 2 × 10 5 ...tion, breast cancer cells were exposed to 50 μg/ml of AM extract for 24 ...Afterward, breast ... See full document
8
<p>Frequency of germline mutations in BRCA1 and BRCA2 in ovarian cancer patients and their effect on treatment outcome</p>
... 2 mutations were detected in 22 patients ...detected mutations, 19 were pathogenic, 1 was of uncertain signi fi cance, and 1 was ...Fifteen mutations were Frameshifts, two were missense, two nonsense, ... See full document
10
Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance
... DTC-positive breast cancer patients will relapse over a ten year period, while the other half will remain free of disease [8] (Table ...additional mutations) as well as in the surrounding ... See full document
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