[PDF] Top 20 Plasticity and Epitope Exposure of the HIV-1 Envelope Trimer
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Plasticity and Epitope Exposure of the HIV-1 Envelope Trimer
... The intraprotomer interface between V1V2 and the gp120 core shown in Fig. 2 was analyzed to identify side chains that contribute significantly to the interactions be- tween the two domains. Because mutations on the V1V2 ... See full document
17
CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity
... are metastable, our assay is best viewed as providing snapshots of a shifting equilibrium between conformational states. By exposing the Env to a wide range of sCD4 concentrations, we demonstrate a simple strategy to ... See full document
27
Exposure of Epitope Residues on the Outer Face of the Chikungunya Virus Envelope Trimer Determines Antibody Neutralizing Efficacy
... CHIKV envelope glycoproteins E2 and ...postexposure. Epitope mapping using a comprehensive shotgun mutagenesis library of 910 mutants with E2/E1 alanine mutations demonstrated that IM-CKV063 binds to an ... See full document
16
Immunogenicity of a Prefusion HIV-1 Envelope Trimer in Complex with a Quaternary-Structure-Specific Antibody
... Our immunization data from guinea pigs verified that the PGT145-trimer complex induced lower titers of antibodies to the V3 region than those induced by the ligand-free trimer, as mea- sured by both binding ... See full document
16
Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens
... present epitope clusters in a targeted ...PGT145 epitope would most likely ben- efit from EDC cross-linking followed by PGT145 positive selec- tion, whereas the PGT151 epitope would be best presented ... See full document
16
Structural Constraints at the Trimer Apex Stabilize the HIV 1 Envelope in a Closed, Antibody Protected Conformation
... entire HIV-1 Env trimer, as shown by their profound impact on distant antigenic sites, argues against a direct role of epitope alteration as a major mechanism for the disrupted neutralization ... See full document
15
Structure and Dynamics of HIV-1 Env Trimer
... on HIV-1 Env contains are epitopes for broadly neutralizing antibodies (bNAbs), those regions are usually conserved regions among all HIV-1 viral strain, and neutralizing antibodies targeting ... See full document
145
Epitope-Independent Purification of Native-Like Envelope Trimers from Diverse HIV-1 Isolates
... BF520.e3 trimer shared similar structural order in regions probed by most diagnostic peptides; however, in peptides from V2, spanning 165 to 181, significant deuterium exchange was observed, suggesting that those ... See full document
12
Mutations in HIV-1 Envelope That Enhance Entry with the Macaque CD4 Receptor Alter Antibody Recognition by Disrupting Quaternary Interactions within the Trimer
... local perturbations of a single epitope. Rather, the data are consis- tent with a model in which this mutation relaxes both constraints on Env in the context of the trimer. Analysis of heterotrimeric Env ... See full document
14
Distinct Mechanisms Regulate Exposure of Neutralizing Epitopes in the V2 and V3 Loops of HIV-1 Envelope
... tier 1 and tier 2 viruses by V2i MAbs compared to V3 ...affect HIV-1 neutralization by V2i and V3 ...the HIV-1 Env trimer, this study indicates that the exposure of V3 and ... See full document
13
An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum
... native trimer on the surface of HIV-1-infected ...Env trimer with regard to the C1 region is dramatically different between viri- ons and virus-infected ...T/F HIV-1 isolates ... See full document
8
Relationships between CD4 Independence, Neutralization Sensitivity, and Exposure of a CD4-Induced Epitope in a Human Immunodeficiency Virus Type 1 Envelope Protein
... Generally, these regions are exposed transiently as a conse- quence of the conformational changes initiated by receptor binding. Such structural intermediates of the fusion process can be targets for small molecule ... See full document
10
Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors
... A HIV-1 ...an epitope in the V2/V3 region of a single protomer that is usually, but not exclusively, conferred to the gp120 envelope glycoprotein by trimer formation and distinguished ... See full document
12
A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype B env Gene
... type 1 (HIV-1) envelope glycoprotein (Env) spike should expose as many epitopes as possible for broadly neutralizing antibodies (bNAbs) but few, if any, for nonneutralizing antibodies ... See full document
16
Evolutionary Dynamics of the Glycan Shield of the Human Immunodeficiency Virus Envelope during Natural Infection and Implications for Exposure of the 2G12 Epitope
... of exposure of neutralizing epitopes on the envelope of HIV-1 during the course of infec- tion may explain how HIV can escape the immune system or why its envelope is such a poor ... See full document
13
Chemically Modified Peptides Based on the Membrane-Proximal External Region of the HIV-1 Envelope Induce High-Titer, Epitope-Specific Nonneutralizing Antibodies in Rabbits
... of epitope-specific B cells with a potential to neutralize HIV may be more ...as trimer bundles with a notable amount of steric protection from gp120 above the MPER and the viral membrane below the ... See full document
8
Stabilizing HIV 1 envelope glycoprotein trimers to induce neutralizing antibodies
... the exposure of this epitope one could hide it, for example by placing the trimer on a ...and trimer bottom non- NAb responses is an attractive hypothesis, there is no formal proof yet that ... See full document
11
Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers
... SOSIP trimer as it is soluble, does not aggregate, and is easier to express and ...SOSIP trimer is ideally suited for further structural investigation of bNAb com- ...the HIV-1 Env V1/V2 and ... See full document
8
Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro
... type 1 (HIV-1) are be- ing tested as immunogens in different animal ...a trimer, and any charged compounds in the formulation could bind to countercharged regions of the trimer and ... See full document
19
Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer
... any HIV vaccine with a protein component (for ei- ther priming or boosting) requires production of a recombinant form to mimic the trimeric, functional HIV-1 envelope spike in quantities ... See full document
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