[PDF] Top 20 Platelets have more than one binding site for von Willebrand factor
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Platelets have more than one binding site for von Willebrand factor
... the binding of 125I-vWF to normal platelets stimulated by thrombin or a combination of ADP + EPI, but completely blocked ristocetin- induced ...binding. Binding induced by thrombin to ... See full document
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Patients with Congenital Factor V Deficiency have Decreased Factor Xa Binding Sites on their Platelets
... Human platelets have binding sites for plasma coagulation Factor X a that are available only after the platelet release ...reaction. Platelets from 15 normal donors bound 216±52 (SD) ... See full document
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Functional domains on von Willebrand factor Recognition of discrete tryptic fragments by monoclonal antibodies that inhibit interaction of von Willebrand factor with platelets and with collagen
... We have identified two functional domains on the von Willebrand factor (VWF) moiety of the Factor VIII-von Willebrand factor complex (FVIII-VWF), one ... See full document
10
Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen
... the binding of von Willebrand factor to collagen type I and type ...the binding of 125I-von Willebrand factor to extracellular matrices of endothelial cells, to ... See full document
10
Interaction of von Willebrand factor with human platelets in the plasma milieu
... The binding of von Willebrand factor (vWf) to stimulated platelets in the plasma milieu was performed using a radiolabeled monoclonal antibody to ...vWf binding to activated ... See full document
9
Distinct abnormalities in the interaction of purified types IIA and IIB von Willebrand factor with the two platelet binding sites, glycoprotein complexes Ib IX and IIb IIIa
... Willebrand factor (vWF) molecules, both lacking the larger multimeric forms, with the two vWF binding sites on platelets, the glycoprotein (GP) Ib-IX and GP IIb-IIIa ...for binding of ... See full document
9
Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets
... for binding is from ...the binding; however, 20 mM of Ca++, Mg++, or EDTA have little ...effect. Binding sites for FVIII/vWF were found only on platelets, and no significant ... See full document
10
Thrombin induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets
... concentration-dependent binding of 125I-labeled F. VIIIVWF in a steady-state system. The binding induced by thrombin was specific because it was inhibited by a 100-fold molar excess of unlabeled ...VIIIVWF ... See full document
12
von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure
... Variant von Willebrand disease designated as type I New York or type Malmö is characterized by enhanced ristocetin-induced platelet agglutination with normal von Willebrand factor ... See full document
10
von Willebrand factor binds to platelets and induces aggregation in platelet type but not type IIB von Willebrand disease
... washed platelets, although at higher concentrations than required for platelet- rich ...washed platelets only when plasma is ...Unstimulated platelets in platelet-rich plasma from patients ... See full document
12
Asialo von Willebrand factor interactions with platelets Interdependence of glycoproteins Ib and IIb/IIIa for binding and aggregation
... 50% more AS-vWf binds to the platelet, and this additional AS-vWf binds almost exclusively to ...enhanced binding of AS-vWf in the absence of fibrinogen, platelet aggregation is much less than that ... See full document
8
Variant von Willebrand's Disease: CHARACTERIZATION OF TWO SUBTYPES BY ANALYSIS OF MULTIMERIC COMPOSITION OF FACTOR VIII/VON WILLEBRAND FACTOR IN PLASMA AND PLATELETS
... We have examined the multimeric composition of factor VIII/von Willebrand factor in plasma and platelet lysates by means of sodium dodecyl sulfate agarose electrophoresis followed by ... See full document
9
Structural basis of von Willebrand factor binding to platelet glycoprotein Ib and collagen Effects of disulfide reduction and limited proteolysis of polymeric von Willebrand factor
... von Willebrand factor (vWF) is a large, multimeric glycoprotein that helps platelets adhere to vascular ...vWF binding to platelet receptors and connective tissue constituents is of ... See full document
8
The Effects of Ristocetin and von Willebrand Factor on Platelet Electrophoretic Mobility
... of platelets in the presence of von Willebrand ...the binding of ristocetin and then the von Willebrand factor acts as a bridge between ...and von Willebrand ... See full document
9
von Willebrand factor binding to platelet GpIb initiates signals for platelet activation
... that von Willebrand factor (vWF) binding to platelet membrane glycoprotein Ib (GpIb) initiates intracellular pathways of platelet activation was ...human platelets treated with ... See full document
7
Factor VIII/von Willebrand factor protein Galactose a cryptic determinant of von Willebrand factor activity
... normal Factor VIII/von Willebrand factor protein has the ability to agglutinate or aggregate normal platelets in the presence of ristocetin (von Willebrand factor ... See full document
5
Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin Role of platelet activation, fibrinogen, and two distinct membrane receptors
... formalin-fixed platelets that was blocked only by the anti-GPIb antibody, suggesting that the binding of vWF to GPIb, even in the absence of ristocetin, results in platelet-platelet interaction that is ... See full document
9
Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings.
... observations have challenged this ...that platelets could act as a bridge between activated brain endothelium not expressing CD36 and IE that only bind to CD36 4 ... See full document
7
von Willebrand factor
... thrombosis. Platelets contribute to maintaining the normal circulation of blood through the preservation of vascu- lar integrity and the control of hemorrhage after ...how platelets respond to vascular ... See full document
7
Functionally thrombasthenic state in normal platelets following the administration of ticlopidine
... Willebrand Factor in response to ristocetin, shape change in response to ADP, collagen, thrombin, or arachidonic acid, or binding of prostaglandin E1 to resting ...and von Willebrand ... See full document
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