[PDF] Top 20 A pooled analysis of mesenchymal stem cell-based therapy for liver disease

... all liver func- tion parameters evaluated—this must be verified since the trim-and-fill sensitivity analysis altered this result at two time ...of pooled studies that could be used to assess an ... See full document

... of liver failure At present, although there are fewer clinical studies on MSC therapy for liver failure, previous studies have con- sistently agreed that MSCs can effectively treat liver fail- ... See full document

... B cell- activating factor of the tumor necrosis factor family (BAFF), belimumab anti-Blys, was the first targeted ther- apy to demonstrate its efficacy in mild to moderate SLE by a randomized clinical trial ... See full document

... Crohn’s disease can be treated with ...combination therapy of Pro- chymal (an MSC-based product) and steroids had no therapeutic effect ...the therapy of immunosuppressant-resistant ... See full document

... of stem cell scientists as well as medical ...vivo analysis showed that MSC could differentiate into func- tional adipocyte, neuron, chondrocyte, myocyte, and ...in stem cell ... See full document

... of disease (pathophysiology), therapeutics and cure; in addition to applying biotechnological innovations to the population with ...modifications. Based on these concepts the present work has proposed to ... See full document

... joint disease. Current mainstays of therapy include activity modification, conservative pain management strategies, weight loss, and if necessary, replacement of the affected ...joint. Mesenchymal ... See full document

... The effectiveness of genetically modified auto-MSCs has been reported in different disease models [50–52]. Similarly, the protective effect of allo-MSCs was im- proved by gene modification. de la Garza-Rodea et ... See full document

... expression analysis, it il- lustrated that more effective UCB-MSC displayed dis- tinctive expression patterns of specific genes including ANGPTL4, ADM, SLC2A3, and CDON after hypoxic preconditioning, and the ... See full document

... Research advances have been made towards improving effectiveness of iPSC generation in the absence of c-Myc. Inhibitors of DNA methyltransferase, histone deacetylase, and valproic acid (VPA) were reported to improve ... See full document

... MSC-based therapy in RILI, clinical research is still lacking despite some employing MSCs in chronic lung disease [6, ...standard therapy drugs, such as nonste- roidal anti-inflammatories, ... See full document

... bone cell, and fat ...generally based on a comparison on basis of hematogenic system, where MSCs are placed inside bone core, undergo self-renewal, and form cells transforming to many scar tissue ...a ... See full document

... of liver inflammation and fibrosis, and the possible use of MSCs in the therapy of immune-mediated liver ...of liver infiltrated inflammatory cells and compare effects of engrafted MSCs versus ... See full document

... ontology analysis showed that various miRNAs, such as miR148a, miR532-5p, miR378, and let-7f, are enriched in the culture medium of MSCs, and these miRNAs can be isolated to regulate different pathways, including ... See full document

... Although MSCs have demonstrated the unique abil- ity and promise to combat degenerative diseases such as OA, they possess another mechanism of regenera- tive abilities not previously discussed: their exosomal products. ... See full document

... severe liver damage caused by a variety of reasons, resulting in serious disorders or decompensation of its synthesis, detoxification, excretion, biotransformation, and other functions, which leads to a group of ... See full document

... limitations, liver transplantation is still very limited in clinical practice, and artificial liver support systems can only temporarily replace and assist liver function, but they are unable to ... See full document

... Adipose-derived mesenchymal stem cell; ALD: Alcoholic liver disease; BM-MSC: Bone marrow-derived mesenchymal stem cell; CB-MSC: Cord blood- derived ... See full document

... staining, liver samples were maintained in 4% para-formaldehyde during over- ...frozen liver sections were directly trans- ferred to a − 70 °C freezer ...of liver tissue excised from the mice were ... See full document

... moiety. Cell surface engineering using the hydrophobic insertions provides an excellent solution to enhance the homing of MSCs to the injured myocar- ...the cell membrane with therapeutic molecules ... See full document