[PDF] Top 20 Potential of Equine Herpesvirus 1 as a Vector for Immunization
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Potential of Equine Herpesvirus 1 as a Vector for Immunization
... novel vector for immunizations and gene therapy. In some cell types, EHV-1 led to the estab- lishment of nonlytic infection, because marker gene expression could be propagated by continuous passage of ... See full document
10
Intramuscular Immunization of Mice with the Live-Attenuated Herpes Simplex Virus 1 Vaccine Strain VC2 Expressing Equine Herpesvirus 1 (EHV-1) Glycoprotein D Generates Anti-EHV-1 Immune Responses in Mice
... combat equine herpesvirus 1 (EHV-1) infection, and several different strategies of vaccination have been investi- gated and developed over the past few ...virus 1 (HSV-1) VC2 ... See full document
15
Impact of ETIF Deletion on Safety and Immunogenicity of Equine Herpesvirus Type 1-Vectored Vaccines
... viral vector systems is often limited by factors such as preexisting immunity, toxicity, low packaging capacity, or weak immunogenic ...viral vector system derived from equine herpesvirus type ... See full document
12
Immunization by Replication-Competent Controlled Herpesvirus Vectors
... the immunization effects of once-activated replication-competent controlled vectors that undergo one round of ...as potential vaccines ...upon immunization is not supposed to be capable of ... See full document
20
Equine Herpesvirus 1 Bridles T Lymphocytes To Reach Its Target Organs
... ABSTRACT Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing ... See full document
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Characterization of the trans-Activation Properties of Equine Herpesvirus 1 EICP0 Protein
... Cells and virus. Cultures of L-M (murine fibroblast) cells were maintained as described previously (40, 43). The Kentucky A (KyA) strain of EHV-1 was propagated in L-M suspension culture at a low multiplicity of ... See full document
9
Detection of latency-associated transcripts of equid herpesvirus 1 in equine leukocytes but not in trigeminal ganglia.
... into vector pSPT18 as described in Materials and ...Constructs 1, 7, 3, and 9 are coterminal nested deletions, and constructs 2, 5, and 8 are ...construct 1 by digestion with restriction endonuclease ... See full document
7
An equine herpesvirus type 1 (EHV 1) vector expressing Rift Valley fever virus (RVFV) Gn and Gc induces neutralizing antibodies in sheep
... delivery vector. Equine herpesvirus type 1 (EHV-1) is a member of the genus Varicellovirus in the subfamily ...virus vector against various ...the vector and provide ... See full document
8
Experimental infection with equine herpesvirus type 1 (EHV-1) induces chorioretinal lesions
... as potential causes of the lesions ...experiment 1, although preliminary in nature, do not suggest that EHV-1 translocates to the eye by direct extension through the cen- tral nervous system using ... See full document
15
The Unique IR2 Protein of Equine Herpesvirus 1 Negatively Regulates Viral Gene Expression
... (iii) CAT and luciferase reporter plasmids. Plasmids pgK-CAT, pgK( ⫺ 153/ ⫹14)-CAT, pgK(⫺83/⫹14)-CAT, pIE-CAT [pIE(⫺802/⫹73)-CAT], pTK-CAT, and pEICP0-CAT [pEICP0( ⫺ 335/-21)-CAT], and pEICP22(E)-CAT have been described ... See full document
9
Mapping the termini and intron of the spliced immediate-early transcript of equine herpesvirus 1.
... Finally, although potential splice donor and splice acceptor sites were identified at the 3' terminus of the IE gene by DNA sequencing 28, splicing in this region was not detected by usi[r] ... See full document
10
Regulatory function of the equine herpesvirus 1 ICP27 gene product.
... of equine herpesvirus 1 (EHV-1) KyA strain is a homolog of the ICP27 a regulatory protein of herpes simplex virus type 1 (HSV-1) and the ORF 4 protein of varicella-zoster ... See full document
8
Equine Herpesvirus Type 1-Mediated Oncolysis of Human Glioblastoma Multiforme Cells
... EHV-1 has many favorable properties that make it a potential new member in the arsenal of anticancer agents. The virus has a short, well-defined growth cycle that results in the death of in- fected cells, ... See full document
5
Bovine herpesvirus 4 based vector as a potential oncolytic virus for treatment of glioma
... with 1 TCID50/cell of a recom- binant BoHV-4 expressing EGFP (BoHV-4EGFPΔTK) [3] and its effects were observed after 24, 48, 72, 96, 144, 216 hours post infection with an epi-fluorescence microscope ...which ... See full document
6
Expression and function of the equine herpesvirus 1 virion-associated host shutoff homolog.
... phosphoprotein (7, 28). Because the predicted UL13 protein sequence contains motifs with homology to known protein kinases, its potential role in phosphorylation of viral and host proteins has been examined with ... See full document
9
Equine Multinodular Pulmonary Fibrosis in association with asinine herpesvirus type 5 and equine herpesvirus type 5: a case report
... Equine herpesvirus type 5 (EHV-5) is one of the nine herpesviruses known to infect Equidae ...as equine gammaherpesviruses ...the potential role of EHV-5 causing clinically or subclinical ... See full document
5
Mapping the Sequences That Mediate Interaction of the Equine Herpesvirus 1 Immediate-Early Protein and Human TFIIB
... parent vector pTriEx-1 (lane 2) or with pTriExIE (1–1487) containing the entire IE gene (lane 3) or were cotransfected with pTriExIE and pTriExhIIB containing the entire human TFIIB (hTFIIB) gene ... See full document
12
Cloning, Expression, and Functional Characterization of the Equine Herpesvirus 1 DNA Polymerase and Its Accessory Subunit
... pTM1 vector, which con- tains the EMV 5 ⬘ UTR downstream from the T7 promoter ...Fig. 1, a protein of approximately 45 kDa, corre- sponding to the predicted 405-aa pORF18, was synthesized from pTM1-ORF18 ... See full document
12
The Equine Herpesvirus 1 UL20 Product Interacts with Glycoprotein K and Promotes Egress of Mature Particles
... within vector pTZ18R and encompasses UL20 encoding, as well as upstream and downstream sequences ...bp 1 to 208 or the complete 719-bp UL20 ORF (gene 41 [31]) was amplified by ...either vector ... See full document
13
Immunization with Attenuated Equine Herpesvirus 1 Strain KyA Induces Innate Immune Responses That Protect Mice from Lethal Challenge
... no equine vaccine that has a label claim for protection against the neurological strain of the ...KyA immunization greatly increased the number of genes with changed expression, as well as the levels of ... See full document
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