[PDF] Top 20 Proatherogenic immune responses are regulated by the PD 1/PD L pathway in mice
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Proatherogenic immune responses are regulated by the PD 1/PD L pathway in mice
... cell immune-mediated responses (10, 11). PD-L1 and PD-L2 are highly expressed after antigen stimulation on APCs, specifically DCs, macrophages, and B cells ...(12). PD-1 on T ... See full document
10
The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients
... of immune tolerance. PD-1 negatively regulates innate immune cells, the failure of which can cause the activation of autoimmunity ...between PD-1 and PD- L1 promoted ... See full document
12
Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
... 2010). Mice are not a natural host of influenza; however, several strains have been adapted by serial passage for use in mouse ...of mice leads to infection of epithelial cells in the bronchi and ...in ... See full document
129
The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies
... of PD-1, and natural killer T-cells express low levels of ...that PD-L1 is expressed at high levels by activated CD4+T cells ...Although PD- 1 was not preferentially expressed in pro-B ... See full document
6
Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts
... the mice or GVHD, supports a tumor-specific ...the responses to the tumor would be more robust in these mice, which should harbor a higher frequency of tumor-reactive specificities, than a patient, ... See full document
16
Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma
... myeloma-bearing mice, and anti-myeloma synergy occurred when the PD-1/PD-L1 axis was blocked in combination with blocking TIM-3, LAG-3, or ...of PD-L1 plus the ligand for 2B4, CD48, did ... See full document
15
Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway
... However, immune checkpoints such as cytotoxic T-lymphocyte- associated antigen (CTLA)-4 and programmed cell death (PD)-1 receptor and its ligands (PD-L1, PD-L2) suppress the activity of ... See full document
9
Promotion of a Subdominant CD8 T Cell Response during Murine Gammaherpesvirus 68 Infection in the Absence of CD4 T Cell Help
... for immune control of murine gammaherpesvirus 68 ( ␥ HV68) ...immunocompetent mice, acute ␥ HV68 infection results in lifelong latency, but in the absence of CD4 T cell help, mice succumb to viral ... See full document
8
Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer
... file 1: Figure S1). Our results further showed that HAT1 regulated PD-L1 expression in pan- creatic cancer ...and PD-L1 has been reported to promote tumor cell growth not only via ... See full document
12
Emerging biomarkers for PD-1 pathway cancer therapy.
... infiltrating immune cells by gene expression profiling and IHC of colorectal cancer samples, high densities of CD3 + T cells, CD8 + cytotoxic T cells and CD45RO + memory T cells were associated with decreased ... See full document
35
Cancer immunotherapies targeting the PD-1 signaling pathway
... The concept of cancer immunotherapy goes back to the late nineteenth century. In 1891, a young New York sur- geon named William Coley began intra-tumoral injec- tions of bacterial products and observed tumor shrinkage in ... See full document
11
PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective
... anti-tumor immune responses, leading to eradica- tion of distal tumors ...general immune homeostasis, targeting this pathway could be met with severe autoimmune toxicities, which was shown to ... See full document
8
Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?
... the PD-1/PD-L1 pathway has elicited durable antitumor responses in the therapy of a broad spectrum of ...cancers. PD-L1 is constitutively expressed in certain tumors and host ... See full document
8
Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions
... family, PD-L1 (B7-H1). PD-L1 binds to PD-1, an inhibitory immune checkpoint receptor, and delivers a negative signal to shut down T cell activation (13, ...tested PD-L1 levels ... See full document
15
Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients
... broad immune sup- pressive activity ...tumor immune responses in pre-clinical studies [6, ...active PD-1/PD-L1 pathway limited the effective- ness of the treatment ... See full document
8
The importance of the PD 1/PD L1 pathway at the maternal fetal interface
... mune responses. Checkpoint inhibitors (PD-1, TIM-3, TIGIT, ...effector immune responses and cellular interactions pre- venting from deleterious autoimmune effects, but their ... See full document
12
IL 6/JAK1 pathway drives PD L1 Y112 phosphorylation to promote cancer immune evasion
... signaling pathway for initiating the glycosylation process of PD-L1 is not well ...anti– PD-1/PD-L1 treatment or a new marker-guided combination ...IL-6/JAK1/ PD-L1–p-Y112/STT3A ... See full document
16
Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November–2 December, 2017, Naples, Italy)
... dabrafenib (a BRAF inhibitor) and trametinib (a MEK mitogen-activated protein kinase inhibitor), obesity was associated with improved outcomes [7]. Indeed, there was an inverse linear relationship between body mass index ... See full document
13
Immune checkpoint blockade: the role of PD-1-PD-L axis in lymphoid malignancies
... antitumor immune responses offering a better support for subsequent ...of immune checkpoint blockade concomitantly with classical chemotherapy could enhance the antitumor response by creating a tumor ... See full document
15
Co-mutations of TP53 and KRAS serve as potential biomarkers for immune checkpoint blockade in squamous-cell non-small cell lung cancer: a case report
... to PD-1 blockade immunotherapy ...the PD-1 blockade immunotherapy, such as weak PD-L1 ex- pression, MSI and TMB-low, had indicated invalid im- ...up-regulating PD-L1 expression, ... See full document
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