[PDF] Top 20 Prognostic and predictive values of PD-L1 expression in patients with digestive system cancer: a meta-analysis

... “digestive system cancer,” “colorectal neoplasms,” “esophageal neoplasms,” “gastric cancer,” “hepatocellular carcinomas,” “pancreatic carcinomas,” “biliary tract neoplasms,” and ... See full document

... gastric cancer (GC). However, whether the expression of PD-L1 in tumor cells or blood serum is associated with the prognosis of patients with GC remains ...a meta-analysis ... See full document

... published meta-anal- ysis elucidating the prognostic value of some immune checkpoints in head and neck cancer were completely different from our meta-analysis and the previous study of ... See full document

... of digestive sys- tem ...of cancer cases, includ- ing lymph node metastasis, tumor grade, and differentiation, were not adjusted for in some ...this analysis was conducted using as many multivariate ... See full document

... in cancer and plays a pivotal role in the initiation and progression of ...and prognostic value of PD-L1 in pancreatic cancer (PC) remains ...a meta-analysis to ... See full document

... Our meta-analysis enrolled 3000 NSCLC patients, which far exceeded their sample ...our meta-analysis and our data were fresh compared to ... See full document

... and prognostic roles. As Liu et al. [27] reported, PD-L1 expressed on tumour cells was negatively correlated with the prognosis, while PD-L1 expressed on macrophages was positively ... See full document

... the prognostic and clinical value of PD-L1 for ...high PD-L1 expression predicted poor OS and DFS/RFS in HCC; in addition, high PD-L1 expression was ... See full document

... L1 expression in colorectal ...rst meta-analysis focus on the prognosis and clinicopatho- logical characteristics of patients with colorectal ...that PD-L1 overexpression ... See full document

... Normally, PD-L1 expression maintains the homeostasis of the immune ...immune system, the activation of the PD-1/PD-L1 path- way can limit autoimmunity and inhibit the ... See full document

... most patients have already been in the advanced stage [5, ...of patients with metastatic disease is still less than 10% [7], which is prob- ably due to the inability to diagnose early and the lack of ... See full document

... type patients in melanoma group, and the squamous cancer patient or non-squamous cancer patients in NSCLC group had gained better outcome of ...in patients without smoking history and ... See full document

... the patients had completed comprehensive treatment and when routine blood examination had returned to normal, a sample of heparinized peripheral blood (50–60 mL) was ...phenotypic analysis and the detection ... See full document

... the prognostic value of CXCL12 methylation can be transferred to a biopsy-based cohort, its analysis may be a promising tool in order to identify patients with innocuous tumors that can safely be ... See full document

... In patients with a metastatic and/or unresectable GC, biopsy specimens might be obtained from the liver metastases, rather than the primary tumor, and biomarker expression between the primary GC and the ... See full document

... The expression of PD-L1 and PD-1 in 80 patients diagnosed with PNETs were inves- ...Immunohistochemical analysis was performed on 80 formalin-fixed paraffin-embedded tissue ... See full document

... APE1 expression, and its expression was associated with tumor infiltration depth, lymph node metastasis, histopathologic type, and the prognosis of gastric cancer patients ...positive ... See full document

... subgroup analysis by factors of sample size (fewer than 100 or more than 100), type of cancer (digestive system or non-digestive sys- tem carcinoma), follow-up time (fewer than 100 or ... See full document

... high PD-L1 expression heterogeneity in the tumor microenvironment could further reduce the potential role applicability of such predictive biomarker for clinical setting ...Indeed ... See full document

... current meta-analysis had some limita- tions calling for cautious interpretation of the ...our meta-analysis, and the data of three cohorts were from databases online (such as TCGA and ... See full document