[PDF] Top 20 Protein Array Identification of Substrates of the Epstein-Barr Virus Protein Kinase BGLF4
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Protein Array Identification of Substrates of the Epstein-Barr Virus Protein Kinase BGLF4
... a BGLF4-expressing vector. Inducible expression of BGLF4 in the Akata-BGLF4 cells and expression of endogenous EBNA1 are illustrated in the West- ern blots in ...where BGLF4 was detected using ... See full document
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SUMO Binding by the Epstein-Barr Virus Protein Kinase BGLF4 Is Crucial for BGLF4 Function
... mSIM-N BGLF4 mutant had no effect on ZTA SUMOylation ...the kinase activity of BGLF4 played a role in abolishing ZTA SUMOylation, ZTA was cotransfected with the kinase-dead BGLF4 ...of ... See full document
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Epstein-Barr Virus Protein Kinase BGLF4 Is a Virion Tegument Protein That Dissociates from Virions in a Phosphorylation-Dependent Process and Phosphorylates the Viral Immediate-Early Protein BZLF1
... homologue BGLF4 is a serine/threonine protein kinase and is the only protein kinase identified in the EBV genome (2, 3, 13, 14, ...The BGLF4 gene is expressed in the lytic ... See full document
10
Maribavir Inhibits Epstein-Barr Virus Transcription through the EBV Protein Kinase
... 1 Protein expression in induced PK knockout and revertant cell ...against BGLF4, RR1, and BMRF1. The faint bands in the BGLF4 panel are likely ...fluorescent protein (GFP)-labeled EBV genome ... See full document
5
Epstein-Barr Virus BGLF4 Kinase Suppresses the Interferon Regulatory Factor 3 Signaling Pathway
... directed kinase, the Gal4-IRF3 fusion protein (wild type or S339A), which contains aa 57 to 427 of IRF3, and the Gal4- luciferase reporter system (60) were used to determine whether BGLF4 adapts a ... See full document
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Simian Virus 40 T/t Antigens and Lamin A/C Small Interfering RNA Rescue the Phenotype of an Epstein-Barr Virus Protein Kinase (BGLF4) Mutant
... EBV kinase induces hyperphosphorylation of the EBV BMRF1 protein, neither the HCMV nor the KSHV kinases can induce this hyperphosphorylation (data not ...its kinase function and not shared by the ... See full document
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Epstein-Barr Virus BGLF4 Kinase Induces Disassembly of the Nuclear Lamina To Facilitate Virion Production
... at BGLF4 target sites reduces EBV BFRF1/BFLF2 protein expression and virion ...The protein expression was detected by anti-GFP JL-8, anti-lamin A/C 636, NPC-47 serum (for EBNA-1), anti-Zta 4F10, ... See full document
14
Epstein-Barr virus latent membrane protein 2 associates with and is a substrate for mitogen-activated protein kinase.
... fusion protein, they were both phosphorylated principally on serine ...of kinase activations following signal ...were substrates for MAPK when acti- vated MAPK was added to the fusion proteins in ... See full document
9
Sumoylation of the Epstein-Barr Virus BZLF1 Protein Inhibits Its Transcriptional Activity and Is Regulated by the Virus-Encoded Protein Kinase
... ) and was a gift from Diane Hayward. pGal4-Z-WT(1-167), pGal4-ZK12A(1-167), and pGal4- ZK12R(1-167) were generated by amplifying amino acids 1 to 167 from pSG5-Z, pSG5-ZK12A, and pSG5-ZK12R, respectively, with ... See full document
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Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus.
... 450 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest By using amino acid sequence patterns motifs diagnostic of conserved regions within the catalytic domains of protein[r] ... See full document
6
Epstein-Barr Virus BGLF4 Kinase Downregulates NF-κB Transactivation through Phosphorylation of Coactivator UXT
... Epstein-Barr virus (EBV) BGLF4 is a member of the conserved herpesvirus kinases that regulate multiple cellular and viral sub- strates and play an important role in the viral lytic ...cycles. ... See full document
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Hyperphosphorylation of EBNA2 by Epstein-Barr Virus Protein Kinase Suppresses Transactivation of the LMP1 Promoter
... nor kinase-dead PK alone activates LMP1 promoter ...the kinase-dead PK has no such ...with kinase- dead PK ...the kinase activity of PK is involved in this ... See full document
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Epstein-Barr Virus BGLF4 Kinase Induces Premature Chromosome Condensation through Activation of Condensin and Topoisomerase II
... that BGLF4 regulates chromosome condensation and other mito- sis-like events, such as lamin disassembly and rearrangement of the cytoskeleton, in a manner dependent on kinase activity ...by BGLF4 ... See full document
16
The Epstein-Barr Virus BILF1 Gene Encodes a G Protein-Coupled Receptor That Inhibits Phosphorylation of RNA-Dependent Protein Kinase
... cellular protein kinases, extracts of viral GPCR- expressing COS-7 cells were used in an immunoblot screen with an array of antibodies directed against a variety of phos- phoproteins (Kinetworks ... See full document
9
Epstein-Barr Virus Protein Kinase BGLF4 Targets the Nucleus through Interaction with Nucleoporins
... of BGLF4 or GFP-BGLF4 were gener- ated using a single-primer mutagenesis protocol ...generating BGLF4 mutants are listed elsewhere (data not shown; ...with kinase domain mutations D195A, ... See full document
14
The Epstein-Barr Virus Protein Kinase BGLF4 and the Exonuclease BGLF5 Have Opposite Effects on the Regulation of Viral Protein Production
... ⌬ BGLF4 mutant showed an altered ...⌬ BGLF4-Rev revertant had regained the wild-type allele (lane ...⌬ BGLF4 and 293/ ⌬ BGLF4-Rev). The ⌬ BGLF4-Rev DNA was further digested with BglII ... See full document
15
Epstein-Barr Virus-Encoded Protein Kinase (BGLF4) Is Involved in Production of Infectious Virus
... EBV BGLF4 knockdown phenotype in order to begin to understand the biological role of the PK encoded by this ...the BGLF4 knockdown phenotype and a BFRF1 knockout phe- notype reported previously ...US3 ... See full document
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A Protein Kinase Activity Associated with Epstein-Barr Virus BGLF4 Phosphorylates the Viral Early Antigen EA-D In Vitro
... of BGLF4 in a eukaryotic system and autophos- phorylation of ...situ kinase assay (22), but the result was negative (data not ...the protein was required for kinase ...the BGLF4 ... See full document
12
Expression and Localization of the Epstein-Barr Virus-Encoded Protein Kinase
... The protein kinase (PK) encoded by the Epstein-Barr Virus (EBV) BGLF4 gene is the only EBV protein ...the protein were analyzed with a polyclonal antiserum raised ... See full document
7
Regulation of the Epstein-Barr Virus C Promoter by AUF1 and the Cyclic AMP/Protein Kinase A Signaling Pathway
... FIG. 5. CBF2/AUF1 binding activity is increased by induction of the cAMP/ PKA signal transduction pathway. (A) Autoradiograph of an EMSA that shows CBF2/AUF1 binding from heparin-Sepharose-purified CA46 control extracts ... See full document
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