[PDF] Top 20 Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
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Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
... altered antigen presentation, and indeed, the major peptide supplier to the ER, TAP, has been shown to be the target of a number of different ...cient antigen presentation ... See full document
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Requirements for the Selective Degradation of Endoplasmic Reticulum-Resident Major Histocompatibility Complex Class I Proteins by the Viral Immune Evasion Molecule mK3
... surface class I expression by targeting nascent class I molecules in the ER for degradation in a proteasome-dependent manner (5, 53, ...ER-resident class I heavy chains are ... See full document
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Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Revealed by Two Peptide Complex Structures and Insights into Immune Escape of Simian Immunodeficiency Virus
... MHC class I (MHC I) molecules of rhesus macaques have been thoroughly se- quenced genetically, indicating their close relationship with susceptibility and the pathogenesis of SIV infection (27, 48, ... See full document
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Posttranscriptional Inhibition of Class I Major Histocompatibility Complex Presentation on Hepatocytes and Lymphoid Cells in Chronic Woodchuck Hepatitis Virus Infection
... of class I heterodimers and the availability of processed viral peptides for their ...increased presentation of class I complexes on liver cells irrespective of the phase of ... See full document
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Cytotoxic T-Lymphocyte Target Proteins and Their Major Histocompatibility Complex Class I Restriction in Response to Adenovirus Vectors Delivered to Mouse Liver
... by antigen-specific ...lysed target cells in vitro very efficiently and resulted in rapid target cell destruction and hence transient gene expression in ...MHC peptide binding sites which are ... See full document
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Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides
... 5 Peptide binding with FLA-E*01801 indicated by in vitro ...FLA-E*01801 complex were tested by alanine scanning, CD spectroscopy, and peptide ...a peptide was included as a negative ... See full document
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Initial Studies for the Characterization of a Major Histocompatibility Complex Class I Restricted, Peptide-Specific Cytotoxic T Lymphocyte Response in Dogs.
... and presentation of peptides from whole proteins is a complex process involving many steps including protein degradation by the proteasome and transport of peptides into the ER by the TAP ...the ... See full document
164
Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains.
... dominant target of CTLs after infection of mice by murine CMV is the immediate-early protein pp89 (31, ...IE1 peptide presentation on the cell ...the viral latent or persistent phase or during ... See full document
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Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells.
... of class I-deficient target cells to NK cells; this occurred under conditions in which class I expression on the plasma membrane was not reduced, leading to specu- lation that ... See full document
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Inhibition of HLA-DR Assembly, Transport, and Loading by Human Cytomegalovirus Glycoprotein US3: a Novel Mechanism for Evading Major Histocompatibility Complex Class II Antigen Presentation
... expresses viral genes weakly or not at all in cultured cells that express class ...of viral genes is often low in those macrophages that are ...of class II molecules has been observed with ... See full document
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Downregulation of Major Histocompatibility Complex Class I Molecules by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Proteins
... MHC class I molecules (26). In this report, we add two KSHV proteins to an increasing list of viral proteins which apparently interfere with cellular ...the viral genome and are ... See full document
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Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression
... Nef proteins have evolved different surfaces to carry out interactions with the same cellular factors and why they have evolved different mechanisms to achieve similar perturbations of target cell bi- ... See full document
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An Efficient and Versatile Mammalian Viral Vector System for Major Histocompatibility Complex Class I/Peptide Complexes
... Class I molecules of the major histocompatibility complex (MHC)—human leukocyte antigen (HLA) in humans—play crucial roles in cellular immune responses in ...MHC class ... See full document
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Human Cytomegalovirus pp71 Stimulates Major Histocompatibility Complex Class I Presentation of IE1-Derived Peptides at Immediate Early Times of Infection
... of viral mutants contain different amounts of ...IE1 peptide presentation at IE times of infection with pp65-negative mutants correlated with the particular pp71 levels that the mu- tants ...HCMV ... See full document
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Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus
... Despite reduced protein synthesis, production of antigenic peptides is quantitatively similar in macrophages and fibro- blasts. The pp89 protein is not part of the virion, and its detection requires de novo viral ... See full document
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Human Herpesvirus 7 U21 Tetramerizes To Associate with Class I Major Histocompatibility Complex Molecules
... of class I MHC molecules to lysosomes, the simplest is one exemplified by the MCMV m06 immunoevasin ...m06-class I MHC complex to the lysosomal compartment ...of class I ... See full document
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Molecular Determinants of Peptide Binding to Two Common Rhesus Macaque Major Histocompatibility Complex Class II Molecules
... Rev peptide pool (1 g of each peptide/ sample) was tested in three different ...Flu peptide (SNEGSYFI; 1 g/ sample) was used as a negative control, and staphylococcal enterotoxin B (SEB) (10 g/ml; ... See full document
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Influenza Virus Infection Augments NK Cell Inhibition through Reorganization of Major Histocompatibility Complex Class I Proteins
... increased inhibition of NK cell cytotoxicity, whereas NKp46- mediated activation is observed only later. What is the physi- ological importance of these time differences between inhibi- tion and activation? One possible ... See full document
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Human T-cell leukemia virus type I trans activator induces class I major histocompatibility complex antigen expression in glial cells.
... 8 0022-538X/90/084002-05$02.00/0 Copyright C 1990, American Society for Microbiology Human T-Cell Leukemia Virus Type I trans Activator Induces Class I Major Histocompatibility Complex A[r] ... See full document
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Characterization of a major histocompatibility complex class I antigen-binding glycoprotein from adenovirus type 35, a type associated with immunocompromised hosts.
... Ad35 E29 is analogous to the group C Ad2 early glycoprotein E3-19K E19, which has been shown to interfere with the expression of class I antigens on the cell surface H.. In contrast to t[r] ... See full document
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