[PDF] Top 20 Protocol for treatment of Achilles tendon ruptures; a systematic review with network meta-analysis

... the Achilles tendon, surgery may result in devastating wound complications and infections [2, ...operative treatment, leading some to advise surgery for more active patients [9, ... See full document

... The extracted records retrieved by both of the databases will be merged and duplicates will be removed on the basis of title and year of publication using MS Excel 2007. In the first phase, two reviewers with experience ... See full document

... of treatment benefit; however, these categorical measures are created arbitrarily from underlying continu- ous rating scale data ...inflate treatment differences relative to the mean change on the ... See full document

... The network of treatments will be judged based on the available study data presented and evaluated ...in network with no available data, if there is a high number of comparisons based on single studies, if ... See full document

... (systematic review, system- atic review and meta-analysis, meta-analysis, or network meta-analysis); publication date; number of databases sourced and ... See full document

... Since insulin deficiency occurs in T1DM, the treatment of this condition requires the use of insulin. Basal insulin replacement can be achieved with human or purified porcine intermediate-acting insulin, including ... See full document

... indirect treatment comparison) and consistency (for mixed-treatment comparison) before conducting a net- work ...every treatment group of every study and specify the relations among the effect sizes ... See full document

... UK, treatment for NOAF is based upon the Na- tional Institute for Health and Care Excellence (NICE) guidelines for the management of AF, whilst in the USA, treatment recommendations are based upon the ... See full document

... however, treatment of idiopathic SSNHL is controversial because some patients recover ...planned systematic review and network meta-analysis (NMA) will assess the relative ... See full document

... In this study, the meta-analysis by McMahon et al. [14] was selected according to the Jadad decision algorithm. Their study demonstrated that there were no differences between MIS and OS with respect to ... See full document

... Continuous outcome data from behavioural tests will be extracted by two independent authors (DTL and ACP), and any disagreement will be discussed with a third author (EHG). Data will be extracted directly from the ... See full document

... A survey conducted expressly to evaluate practitioners' beliefs concerning a set of clinical questions may support a claim of clinical equipoise for a particular trial. For example, a survey was conducted, and reported ... See full document

... anti-CTLA-4 treatment in BRCA1 deficient ovarian can- cer model ...combination treatment completely eliminated visible tumor mass and maintained a long-term tumor- free survival in most of mice ... See full document

... a protocol for the systematic review search strategy, extraction method, synthesis and appraisal of the quality of published evidence in relation to maternity service organisational interventions ... See full document

... first systematic review on physical therapies for AT to utilise methodological quality ratings and conduct meta-analyses, there are limitations that must be ...three meta-analyses were ... See full document

... of systematic reviews ...of systematic reviews and meta-analyses published in the field of ophthalmology has dramatically increased over the last decade [24, ... See full document

... injections, versus Shetty et al 8 in which the authors found a statistically significant difference in favor of PRP for similar patient-reported functional outcomes when they also compared PRP to corticosteroid ... See full document

... A Trial Steering Committee (TSC) and a Data and Safety Monitoring Committee (DSMC) will be set up. The study DSMC will adopt a DAMOCLES (DAta MOnitoring Committees: Lessons, Ethics, Statistics) charter which defines its ... See full document

... We will assess for heterogeneity between studies using the Mantel-Haenszel χ 2 statistic (P < 0.01 indicating sub- stantial heterogeneity) and the I 2 statistic [16]. We con- sider I 2 > 50% to indicated a ... See full document

... for analysis with the standardised mean differences ...ate meta-analyses will be ...statistic. Meta-analysis with an I 2 > 40% will be considered to have substantial heterogeneity, and ... See full document