[PDF] Top 20 Quantification of rimonabant in rat plasma by high performance liquid chromatography and its application to pharmacokinetic studies

... Accuracy data in the present study ranged from 98.59 to 99.76% (Table 3) indicates that there was no interference from endogenous plasma components. Inter-day as well as intra-day replicates of RMT, gave an R.S.D. ... See full document

... from rat plasma. Detection of imatinib in rat plasma by the high performance liquid chromatography method was accurate and precise with a quantitation limit of ... See full document

... The plasma samples were treated with the protein precipitating agent for the analysis of ...spiked plasma with PRQ (different concentration) and diazepam (fixed concentration) were taken in ...blank ... See full document

... blank plasma demonstrated the selectivity of the method. Blank plasma was spiked with standard solution analytes and IS while plasma samples were obtained from different groups at 2 min after ... See full document

... in plasma samples is essential for pharmacokinetic ...the quantification of metformin in human plasma or in pharmaceutical forms, these ultraviolet (UV) spectrometry (Vesterqvis et ...for ... See full document

... Optimization of physicochemical variables was performed using a multivariate experimental design. Following the recommendations given in the Veterinary International Conference on Harmonization guides (VICH GL02 and VICH ... See full document

... the quantification of budesonide in human plasma samples obtained for pharmacokinetic ...gave high recovery for the ...(BA/BE) studies and routine therapeutic drug monitoring with the ... See full document

... in rat plasma, bench top stability, freeze thaw stability, auto injector stability and long term stability studies were carried out by using six replicates of the low and high plasma ... See full document

... in rat plasma. To study the pharmacokinetic interaction between these two drugs in hyperlipidemic rats, we developed the new, simple method for simultaneous estimation of simvastatin and nifedipine ... See full document

... spiked plasma samples (six each of low, medium and high QCs) with the peak area of analytes in samples prepared by spiking extracted drug-free plasma samples with the same amounts of analytes at the ... See full document

... in rat plasma using liquid chromatography coupled to tandem mass spectrometry with electro spray ionization in the positive-ion ...simple liquid-liquid extraction of MEM and ... See full document

... the quantification of IRI in rat plasma, suitable for pharmacokinetic evaluation in preclinical ...optimize chromatography and sample extraction ... See full document

... A liquid chromatographic procedure was developed for the determination of a new anticancer agent bicalutamide in plasma using fluorescence ...detection. Chromatography was performed using a reversed ... See full document

... and its metabolites in rabbit plasma was ...and its metabolites in rabbit plasma and the structure of the metabolites were characterized through retro-synthesis followed by MS and NMR ... See full document

... stress studies should be carried out on active pharmaceutical ingredient to establish its inherent stability characteristics, leading to separation of degradation products and hence supporting the ... See full document

... the pharmacokinetic study was conducted by giving a dose of 20 mg of vortioxetine ...reliable liquid chromatography/electro spray ionization tandem mass spectrometry (LC-MS/MS) (Agilent Technologies) ... See full document

... Male Wistar rats weighing in the range of 200 –250 gm were purchased from National Institute of Biosciences, Pune, India.All the animals were housed in solid bottom polypropylene cages at an ambient temperature of 24 ... See full document

... Many Chinese medicines comprised of herb combin- ation are purported to offer synergism of therapeutic ef- ficacy while lessening adverse effects (Yang et al. 2014). Thai traditional medicines often include a combination ... See full document

... Waters Aquity TM Ultra Performance LC (UPLC), binary solvent manager connected to a Waters Aquity TM Ultra Performance LC sample manager autosampler. Separation was performed on a reversed-phase column ... See full document

... rat plasma. For this purpose, 50 μL of IS (40.0 ng/mL) and 100 μL of plasma sample (respective concentration) was added into labeled polypropylene tubes and vortexed ... See full document