[PDF] Top 20 Quantifying the effects of mutations on receptor binding specificity of influenza viruses
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Quantifying the effects of mutations on receptor binding specificity of influenza viruses
... of receptor binding affinity from swine to human ...90 mutations applied to each consensus HA1 sequence, swine binding or human ...32 mutations that resulted in the amplitude change at ... See full document
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Receptor binding specificity and origin of 2009 H1N1 pandemic influenza virus
... human influenza viruses bind preferen- tially to α2,6 receptors, typically found in the upper air- way of humans, whereas avian influenza viruses tend to bind to α2,3 receptors, also found in ... See full document
15
Subtle differences in receptor binding specificity and gene sequences of the 2009 pandemic H1N1 influenza virus
... HA mutations have an impact on the host cell receptor ...identify mutations in the influenza viruses within or between hosts, and to quantify the contribution from each mutation to ... See full document
10
Effects of Receptor Binding Specificity of Avian Influenza Virus on the Human Innate Immune Response
... the viruses with SA ␣ 2,6 receptor binding receptor ...avian influenza viruses in human respiratory epithelial cells showing that avian influenza viruses induce a ... See full document
11
Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013
... all viruses belong to the clade ...Cambodian viruses clustered in a discrete group made up of samples collected only in Cambodia during 2013 ...all viruses in the 2013 group shared mutations ... See full document
13
The Impact of Receptor Binding Avidity and Immune History on the Antigenic Determination of Influenza A Viruses
... of influenza throughout their lifetime even though protective neutralizing antibodies against the viral hemagglutinin (HA) are generated after both natural infection and ...accumulating mutations in HA ... See full document
91
Highly conserved domains in hemagglutinin of influenza viruses characterizing dual receptor binding
... primary receptor binding preference in [12] (Table ...primary receptor binding preference in different subtypes were discovered (Table ...of receptor binding specificity ... See full document
10
Identification of highly conserved domains in hemagglutinin associated with the receptor binding specificity of influenza viruses: 2009 H1N1, avian H5N1, and swine H1N2
... the mutations and co-mutations, the stalk motifs, and the phylogenetic ...tential mutations and strongly co-mutated positions of NA were ...The mutations of HA in 2009 H1N1 were found and ... See full document
10
In Vitro Assessment of Attachment Pattern and Replication Efficiency of H5N1 Influenza A Viruses with Altered Receptor Specificity
... avian influenza (HPAI) H5N1 virus has been a cause of great ...acquiring specificity for the human influenza A virus receptor, ␣ 2,6-linked sialic acids (SA), and being able to transmit ... See full document
9
Molecular Basis of the Receptor Binding Specificity Switch of the Hemagglutinins from both the 1918 and 2009 Pandemic Influenza A Viruses by a D225G Substitution
... avian receptor to enable dual receptor binding ...H1N1 influenza virus may be partially explained by HA’s high binding affinity and long binding half-life for the ␣2,6 linkage ... See full document
10
Mutations in Hemagglutinin of H5N1 Influenza That Switch Receptor Specificity from Avian to Human Types
... five mutations are required for H5N1 to become transmissible between ferrets via the air ...known mutations: PB2-627K efficient for replica- tion in mammals and HA-Q222L/G224S for human type receptor ... See full document
6
Involvement of the Mannose Receptor in Infection of Macrophages by Influenza Virus
... viral binding or entry has been described previously for certain other envel- oped ...protein receptor (ASGPR) was shown to represent an alter- native route into HepG2 hepatoma cells under conditions where ... See full document
8
Molecular Mechanisms of Serum Resistance of Human Influenza H3N2 Virus and Their Involvement in Virus Adaptation in a New Host
... H3N2 viruses become resistant to horse serum due to their reduced affinity for 4-O-acetylated ...HA mutations (34) (Table ...those viruses became resistant to serum because of a reduced bind- ing to ... See full document
8
Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6
... Crystallization, data collection, and structure determination. Crys- tallization conditions were screened using the hanging-drop vapor diffu- sion method with commercial kits (Hampton Research). H13 crystals were ... See full document
9
Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat
... avian influenza virus, A/duck/Shandong/Q1/2013 (DkQ1), was isolated from domestic ...H5N8 viruses which have been reported in eastern China ...H5N8 viruses circulating in South Korea and Japan in ... See full document
6
A Mutant Influenza Virus That Uses an N1 Neuraminidase as the Receptor-Binding Protein
... of viruses by reverse genetics (16) for a series of other ...of receptor-binding ...no mutations or reversions in HA, but one point mutation, G147R (N2 numbering), was identified in ... See full document
10
Neuraminidase Receptor Binding Variants of Human Influenza A(H3N2) Viruses Resulting from Substitution of Aspartic Acid 151 in the Catalytic Site: a Role in Virus Attachment?
... other mutations selected during in vitro passage, such as the Q136K substitution, which substantially reduces zanamivir susceptibility (14, 33), may give misleading conclusions as to the drug susceptibility of the ... See full document
13
Development of ideas on the nature of viruses
... The preparation of so many plant-viruses in forms with characteristic chemical and physical properties has fostered two unfortunate illusions: that there is a qualitative dis- tinction b[r] ... See full document
5
Genetics, Receptor Binding, and Virulence in Mice of H10N8 Influenza Viruses Isolated from Ducks and Chickens in Live Poultry Markets in China
... in receptor-binding preference from ␣ 2,3-linked sialic acids (Sias) (avian-type receptors) to ␣ 2,6-linked Sias (hu- man-type receptors) is important for an avian influenza virus to transmit among ... See full document
5
Role of Sialic Acid Binding Specificity of the 1918 Influenza Virus Hemagglutinin Protein in Virulence and Pathogenesis for Mice
... the viruses expressing the HA and NA genes rep- resenting the 1918 virus sequences was not solely due to the ability of these viruses to bind ␣ 2-6 ...chimeric viruses. Both the Av-wt and 1918-NYmut ... See full document
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