[PDF] Top 20 Quantitative Structure Activity Relationship Study of Some Antipsychotics by Multiple Linear Regressions
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Quantitative Structure Activity Relationship Study of Some Antipsychotics by Multiple Linear Regressions
... The objectives of this work were to investigate the retention behavior of this kind of compound using reversed-phase thin-layer chromatography, to determine their lipophilicity, to inves[r] ... See full document
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Quantitative Structure Activity Relationship Study of Naphthoquinone Analogs as Possible DNA Topoisomerase Inhibitors
... proposed quantitative model, we tried to interpret the activity of these compounds based on the different multivariate statistical analysis methods like, the principal components analysis (PCA) and ... See full document
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Validation Method Used In Quantitative Structure Activity Relationship
... Quantitative structure activity relationship is study of relationship between physiochemical (independent) properties and biological (dependent) activity of bioactive ... See full document
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QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDIES OF SULFADIAZINE SALICYLALDEHYDE SCHIFF BASE AS AN ANTI MYCOBACTERIAL AGENTS
... ABSTRACT: Quantitative structure activity relationship is among the most widely used computational technology for analogue-based drug ...anti-mycobacterial activity from recently ... See full document
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QSAR, Molecular Docking and Dynamics Studies of Pyrrolo[2,3-b]Pyridine Derivatives as Bruton’s Tyrosine Kinase Inhibitors
... in multiple signaling pathways regulating the B cell receptor, which is identified as an attractive drug target for lymphoid ...present study were to develop a model of Quantitative Structure ... See full document
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Application of neural network to quantitative structure anti-HIV activity relationships of flavonoid compounds
... (anti-HIV) activity for 26 flavonoîd compounds based on quantitative structure- activity relationship method ...stepwise multiple linear regressions technique (MLR) ... See full document
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Quantitative structure activity relationship (QSAR) study of octanol-water partition coefficients of some of environmental toxic of petroleum substances
... the quantitative structure-activity relationship (QSAR) methods that imply analysis of correlations and representation of ...the linear QSAR ...GA-PLS linear model has good ... See full document
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Quantitative structure activity relationship study of parasubstituted trans and cis tamoxifen derivatives
... The QSAR equations were obtained by the stepwise Multiple Linear Regression (MLR) analysis using the SPSS 16.0 software (SPSS Inc.). The HBD (number of hydrogen bond donors) parameter was excluded from the ... See full document
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Structure Activity Relationship Analysis of Antioxidant Activity of Simple Benzene Carboxylic Acids Group Based on Multiple Linear Regression
... Quantitative structure–activity relationship (QSAR), originally evolved from physical organic chemistry, has now evolved as a well-recognized tool for application in chemistry when a ... See full document
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Application of QSAR Methods on the Study of Bioactive Molecules Derived from Isatin
... A study of quantitative structure-activity relationship (QSAR) is applied to a set of 47 molecules derived from isatin, in order to predict the anticancer biological activity of ... See full document
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Hyaluronidase Inhibitory Activity of Pentacylic Triterpenoids from Prismatomeris tetrandra (Roxb ) K Schum: Isolation, Synthesis and QSAR Study
... via structure modification of ursolic acid 1 or commercially ...inhibitory activity of these compounds on the hyaluronidase enzyme was ...A quantitative structure activity ... See full document
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IDENTIFICATION OF NEW HIV 1 PROTEASE INHIBITORS BY MULTIPLE LINEAR REGRESSION (MLR) AND PHYSICO CHEMICAL DESCRIPTORS
... modeling, quantitative structure activity relationship (QSAR) studies were performed on some 5, 6-dihydro-2-pyrones derivatives using statistical ...best multiple linear ... See full document
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Quantitative structure activity relationship studies of anti-proliferative activity of some indole derivatives combining DFT calculations and statistical results
... the quantitative structure-activity relationship ...This study was carried out using the principal component analysis (PCA) method, the multiple linear regression method ... See full document
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Pharmacoinformatic Studies on 4-Thiazolyl-phenoxy Tail Containing Indanyl Acetic Acid Derivatives as PPAR-Pan Agonists as Potent Anti-Diabetic Agent
... Methods: Quantitative Structure-Activity Relationship (QSAR) study is performed by means of Multiple Linear Regression (MLR) analysis on a set of indanyl acetic acid ... See full document
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QSAR PREDICTION OF N-OCTANOL/WATER PARTITION COEFFICIENT FOR POLYCHLORINATED BIPHENYLS
... compounds. Quantitative structure–activity relationship (QSAR) model for logKow of 133 polychlorinated biphenyls (PCBs) is analyzed using multiple linear regression analysis ... See full document
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Molecular modeling of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile as a dipeptidyl peptidase IV (DPP4) inhibitor
... inhibitory activity, 2D-quantitative structure–activity relationship (QSAR) study was carried out to build a linear correlation between physicochemical properties ... See full document
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CoMFA, CoMSIA, HQSAR and molecular docking analysis of ionone-based chalcone derivatives as antiprostate cancer activity
... The β-ionone-based chalcones 1–15, α-ionone-based chalcones 16–22 and 4-hydroxy-β-ionone-based chalcones 23–43 showed considerable cytotoxicity in LNCaP cell line as antiprostate activity (Table 1). Compound 25 ... See full document
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QSAR, Molecular Docking and Dynamics Studies of Quinazoline Derivatives as Inhibitor of Phosphatidylinositol 3-Kinase
... pathway; some of which are in clinical development including PF-04691502 (Pfizer), BEZ235 (Novartis), XL765 (Exelixis/Sanofi-Aventis) and GSK2126458 (GlaxoSmithKline) ... See full document
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3D QSAR OF N SUBSTITUTED IMIDAZOLES AS ANTIFUNGAL AGENTS
... Fluconazole was not considered either for generation or validation of QSAR models, as is doesn‟t have imidazole ring, which is common to all other structures. A training set of fifty molecules (Table 1) was used for ... See full document
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Quantitative Structure Activity Relationship Studies of 4-Methyl-2-(p-Substitutedphenyl) Quinoline Derivatives as Potential Antifungal Agents
... QSAR study of a series of quinoline derivatives has been carried out to find out their antifungal ...The study includes 8 descriptors which have been selected to develop the best fit ...antifungal ... See full document
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