[PDF] Top 20 Regulated processing of hepatitis C virus core protein is linked to subcellular localization.
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Regulated processing of hepatitis C virus core protein is linked to subcellular localization.
... various C-terminal trun- cations of core protein, up to residue 164, result in the nuclear localization (16, 19, 23, ...between core protein proteolytic processing and its ... See full document
6
Interaction between hepatitis C virus core protein and E1 envelope protein.
... the core protein and the E1 enve- lope protein in ...the core protein could indeed interact with the E1 envelope protein, we have also performed an immunofluorescence ... See full document
6
Charged Residues in the Transmembrane Domains of Hepatitis C Virus Glycoproteins Play a Major Role in the Processing, Subcellular Localization, and Assembly of These Envelope Proteins
... in virus budding (26), which is a late stage of virus assem- bly corresponding to the acquisition of a membrane that sur- rounds the nucleocapsid ...(17). Virus budding can occur at the plasma ... See full document
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Subcellular Localization of Hepatitis C Virus Structural Proteins in a Cell Culture System That Efficiently Replicates the Virus
... capsid protein is detected in association with lipid drop- lets in infected ...the C protein was not directly associated with the lipid droplets, and this suggests a localiza- tion of the C ... See full document
10
Subcellular Localization and Function of an Epitope-Tagged p7 Viroporin in Hepatitis C Virus-Producing Cells
... This localization of p7 in the ER and its colocalization with E2 and NS2 reflect the position of p7 in the viral ...E2, core, or NS5A, was ...p7 protein, or might simply be too transient to be ... See full document
15
Inhibition of Hepatitis C Virus Production by Aptamers against the Core Protein
... the virus, these tests cannot distinguish between individuals who have resolved their infection and those who remain actively infected with the ...HCV core antigen test detects circulating core ... See full document
10
Subcellular Localization, Stability, andtrans-Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines
... cific for the ER and mitochondria (48) (data not illustrated). In addition, the tubular structures observed in UNS3-4A cells corresponded to the pattern revealed by the fluorescent dye rhodamine-123, which labels ... See full document
12
The Native Form and Maturation Process of Hepatitis C Virus Core Protein
... Hepatitis C virus (HCV) is the major causative agent of posttransfusion and sporadic non-A, non-B hepatitis (3, ...chronic hepatitis, cirrhosis, and hepatocellular carcinoma (5, 16, ... See full document
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Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles
... serine/threonine protein kinases that block NS5A hyperphosphorylation facili- tate replication of a non-culture-adapted replicon (3, ...membrane protein-associated protein subtype A, a cel- lular ... See full document
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Genetic Analysis of the Carboxy-Terminal Region of the Hepatitis C Virus Core Protein
... intracellular core protein levels, which may ac- count for the observed reduction in progeny ...of core protein expressed in BHK cells (10) and to decrease SPP processing and membrane ... See full document
8
Characterization of Hepatitis C Virus Core Protein Multimerization and Membrane Envelopment: Revelation of a Cascade of Core-Membrane Interactions
... of core plasmids and analyses of membrane-bound and -free core ...strain core protein and C-terminal-truncated mutants tagged with the influenza virus HA epitope at the N ... See full document
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Intramembrane Processing by Signal Peptide Peptidase Regulates the Membrane Localization of Hepatitis C Virus Core Protein and Viral Propagation
... Cell lines and HCV infection. HCV subgenomic RNA was removed from the replicon cell line 9-13 (16) by treatment with alpha interferon. A cell line that was highly permissive for JFH-1 infection was cloned from the ... See full document
13
Molecular Determinants for Subcellular Localization of Hepatitis C Virus Core Protein
... Hepatitis C virus (HCV) core protein is a putative nucleocapsid protein with a number of regulatory ...HCV core protein is mainly located at the endoplasmic ... See full document
11
Subcellular Localization and Topology of the p7 Polypeptide of Hepatitis C Virus
... the subcellular localization of ...its C terminus with a Myc epitope was still detected at the cell surface (data not shown), indicating that the presence of all the HCV proteins does not alter the ... See full document
11
A Disulfide-Bonded Dimer of the Core Protein of Hepatitis C Virus Is Important for Virus-Like Particle Production
... Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, affecting approximately 200 million people worldwide (13, 29, ...for ... See full document
10
Modulation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 by Hepatitis C Virus Core Protein
... HCV core derived from both ge- notype 1b and genotype ...influenza virus-infected cells (10), we selected MAPKAPK3 to explore a possible involvement in HCV-infected ...the protein array data, we per- ... See full document
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Effect of core protein phosphorylation by protein kinase C on encapsidation of RNA within core particles of hepatitis B virus.
... 12 0022-538X194/$04.00+0 Copyright X 1994, American Society for Microbiology Effect of Core Protein Phosphorylation by Protein Kinase C on Encapsidation of RNA within Core Particles of H[r] ... See full document
8
Subcellular Localization and Rearrangement of Endoplasmic Reticulum by Brome Mosaic Virus Capsid Protein
... and protein expression levels in each re- spective ...physically linked and enclose a single, continuous lumen that extends beyond the boundaries of individual cells via the plasmodesmata (PD) (45) that ... See full document
11
Subcellular localization of the Vif protein of human immunodeficiency virus type 1.
... To determine whether regions important for the association of Vif with membranes are also important for function, a transient complementation assay was used to examine the abilities of t[r] ... See full document
9
Hepatitis C Virus Core Protein Is a Dimeric Alpha-Helical Protein Exhibiting Membrane Protein Features
... HCV core protein is a highly basic, RNA-binding pro- tein that presumably forms the viral ...this protein have been relatively poorly characterized, and its structure is ...a C-terminal ... See full document
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