[PDF] Top 20 MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells
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MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells
... RESULTS MxB does not bind to the HIV-1 core bearing the capsid muta- tion ...Although MxB is a restriction factor with the ability to block HIV-1 infection, the ... See full document
9
Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection
... I interferon inhibits viruses through inducing the expression of an- tiviral proteins, including the myxovirus resistance (Mx) ...the MxB protein has been reported to specifically inhibit primate ... See full document
13
Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo
... human interferon alpha (IFN- ␣) bind the same receptor, recent results have demonstrated that they elicit unique host responses and display distinct efficacies in the control of different viral ...in ... See full document
13
Characterization of the Alpha Interferon-Induced Postentry Block to HIV-1 Infection in Primary Human Macrophages and T Cells
... of HIV-1 cDNA in macrophages challenged with ...and cells that had or had not received IFN- ␣ were treated (or not) for 15 min prior to viral ...the infection, bringing the total time ... See full document
13
Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice
... activation observed in HIV-infected human subjects is reproduced in HIV- infected BLT mice, allowing investigators to address preventive measures in a relevant in vivo ...which HIV-infected ... See full document
10
Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon
... with HIV-1 Env- or MLV-A Env-pseudotyped lentivec- tors were not affected or were even enhanced in THP-1 ...and HIV-1 (reviewed in reference ...that HIV-1 infection ... See full document
20
Dynamics of Persistent TT Virus Infection, as Determined in Patients Treated with Alpha Interferon for Concomitant Hepatitis C Virus Infection
... intact cells with little or no ...TTV infection should be expected to produce substantial ...the cells supporting TTV replication in infected hosts are still poorly defined, current evidence points ... See full document
6
Interferon Alpha Enhances NK Cell Function and the Suppressive Capacity of HIV-Specific CD8+ T Cells
... NK cells. To determine whether IFN- ␣ treatment of NK cells could impact their control of HIV-1 replication in vitro, we assessed the suppressive capacities of HD and ES NK cells with ... See full document
14
Myxovirus Resistance Gene A (MxA) Expression Suppresses Influenza A Virus Replication in Alpha Interferon-Treated Primate Cells
... is responsible for suppressing human seasonal influenza A virus replication in primate ...primate cells before primary transcription of the negative- strand virus genome to ...we observed is ... See full document
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“Self” and “Nonself” Manipulation of Interferon Defense during Persistent Infection: Bovine Viral Diarrhea Virus Resists Alpha/Beta Interferon without Blocking Antiviral Activity against Unrelated Viruses Replicating in Its Host Cells
... MDBK cells we did not observe Mx induction with any of the cp and ncp BVDV strains tested, and Mx induction was only rarely detected with cp strains of BVDV in monocyte-derived M ...induction observed in ... See full document
10
Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors
... to HIV-1. Since we observed an increased sensitivity of the P90A CA mutant virus to IFN- ␣-induced MX2-independent antiviral effec- tors ...(Fig. 1), we hypothesized that the host protein ... See full document
12
Host and viral determinants for MxB restriction of HIV 1 infection
... its infection or integration ...of MxB expression on HIV-1 ...from MxB-expressing cells notably supported similar levels of in vitro integration activities as those isolated from ... See full document
20
Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1
... full-length MxB on host cell protein nuclear import and thereby limit cellular damage or even counteract antiviral activity? We should be open to ...the MxB antiviral ...HSV-1-infected cells ... See full document
9
Selective decrease in human immunodeficiency virus type 1 (HIV-1)-induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection.
... FERBAS, 1 † JEANNINE NAVRATIL, 1 ALISON LOGAR, 1 AND CHARLES RINALDO 1,2 * Department of Infectious Diseases and Microbiology 1 and Department of Pathology, 2 University of Pittsburgh Graduate ... See full document
5
Blocking of the Alpha Interferon-Induced Jak-Stat Signaling Pathway by Japanese Encephalitis Virus Infection
... Sinica, 1 and Department of Microbiology and Immunology, National Defense Medical Center, 2 Taipei, Taiwan, Republic of China Received 10 February 2004/Accepted 23 April 2004 The induction of alpha/beta ... See full document
10
MxB binds to the HIV 1 core and prevents the uncoating process of HIV 1
... of MxB to bind to the HIV-1 core in vitro and during ...that MxB interacts with in vitro assembled HIV-1 capsid- nucleocapsid (CA-NC) complexes, which recapitulate the surface of ... See full document
14
Natural Alpha Interferon-Producing Cells Respond to Human Immunodeficiency Virus Type 1 with Alpha Interferon Production and Maturation into Dendritic Cells
... to HIV-1 infection. It is noteworthy that heat-inactivated HIV-1 that lost infec- tivity as shown by provirus integration assay elicited biological effects on IPCs similar to ... See full document
8
Differential expression of interferon induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha
... The limitations of this study included the relatively small number of patients with CHC on whom miRNA analyses were performed. Indeed, although we found dif- ferences in IFN-induced miRNA expression between healthy ... See full document
9
Relative resistance of HIV 1 founder viruses to control by interferon alpha
... with HIV-1 and viruses produced from IMCs of founder HIV genomes can be partially inhibited by type 1 IFNs in ...with HIV-1 were significantly more re- sistant to in vitro ... See full document
18
Contribution of MxB Oligomerization to HIV-1 Capsid Binding and Restriction
... The alpha interferon (IFN- ␣)-inducible restriction factor myxovirus B (MxB) blocks HIV-1 infection after reverse transcription but prior to ...integration. MxB binds to ... See full document
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