[PDF] Top 20 Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication
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Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication
... Mutational escape from CD8 ⫹ T-cell responses is well defined in many viral infections (3, 70), and studies of both HIV-1 and SIV illustrate that CTL escape is a hallmark of both acute ... See full document
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Lack of strong immune selection pressure by the immunodominant, HLA A*0201 restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus 1 infection
... the virus readily adapts and even slight advantages in replication rates can allow one strain to dominate the viral population very rapidly ...CTL response to HIV-1, with pCTL frequencies ... See full document
9
HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition
... also associated with viral control ...expressing HLA-B57/B*5801 (11, 17, ...viral replication capacity (VRC) by both clinical observation and in vitro experiments (8, 23, ...TW10 escape ... See full document
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Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection
... CTL response as a result of mother-to-child transmission of a virus that has adapted successfully to the maternal class I alleles (10, ...their HLA class I alleles with their mothers, it might be ... See full document
6
Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein
... CTL escape mutations on HIV replication capacity in a relevant and reproducible manner is an important step in acquiring the data necessary for teasing apart the contributions of multiple, and at times ... See full document
9
Novel Cytotoxic T-Lymphocyte Escape Mutation by a Three-Amino-Acid Insertion in the Human Immunodeficiency Virus Type 1 p6Pol and p6Gag Late Domain Associated with Drug Resistance
... (Table 1) but lacked detectable serum HIV-1-specific antibod- ...⫹ T-cell counts (median, 1,047 cells/ l) despite a viral load fluctuating between 17,036 to 95,388 copies/ml after the first 3 weeks ... See full document
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Identification of Novel HLA-A2-Restricted Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Epitopes Predicted by the HLA-A2 Supertype Peptide-Binding Motif
... HIV-1 replication (reviewed in ref- erence ...this HLA-Aⴱ0201-restricted epitope was efficiently processed in cell lines infected with HIV-1, inducing lysis of the infected cells by CTL ... See full document
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Frequent and Variable Cytotoxic-T-Lymphocyte Escape-Associated Fitness Costs in the Human Immunodeficiency Virus Type 1 Subtype B Gag Proteins
... CTL escape-associated fitness costs by utilizing a well-described pro- tein folding energy algorithm, FOLDEF (for FOLD-X Energy Function) (51), which can estimate the Gibbs free energy of fold- ing ( ⌬ G) ... See full document
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Antiretroviral Drug Therapy Alters the Profile of Human Immunodeficiency Virus Type 1-Specific T-Cell Responses and Shifts the Immunodominant Cytotoxic T-Lymphocyte Response from Gag to Pol
... of HLA- A2-restricted Gag-specific (SL9) responses in favor of Pol- specific (PR 76-84) responses in treated subjects was having on viral ...responses from established epitopes ...CTL ... See full document
6
Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope despite Multiple Variations in the Epitope Flanking Sequences
... Cytotoxic T lymphocytes (CTL) that recognize viral antigen presented by major histocompatibility complex (MHC) class I antigens have been shown to control viral replication in vivo in animal models ... See full document
8
HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load
... of HLA class I alleles have been associated with slow HIV disease progression, but the relative contribution of the presenting allele versus the restricted epitopes towards this relative protection ... See full document
8
HLA-Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying gag-protease from Elite Controllers of Human Immunodeficiency Virus Type 1
... Human immunodeficiency virus type 1 (HIV-1)-infected persons who maintain plasma viral loads of <50 copies RNA/ml without treatment have been termed elite controllers ...an ... See full document
10
Structural and Functional Constraints Limit Options for Cytotoxic T-Lymphocyte Escape in the Immunodominant HLA-B27-Restricted Epitope in Human Immunodeficiency Virus Type 1 Capsid
... postulated to restore a replication defect (33), although in one report CTL escape in KK10 via development of R 264 G was not associated with E 260 D (8). We now demonstrate that E 260 D does indeed ... See full document
12
Escape and Compensation from Early HLA-B57-Mediated Cytotoxic T-Lymphocyte Pressure on Human Immunodeficiency Virus Type 1 Gag Alter Capsid Interactions with Cyclophilin A
... 4. Escape in TW10 reduces HIV-1 replication ...in replication were seen between the WT (black line) and any of the TW10-associated ...Student’s t test, and the slope of the WT ... See full document
11
Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants
... of escape in HIV transmitters: sample timing is ...taken from D1 before and after week 0 ...p17 Gag HLA A*0301- restricted epitope RLRPGGKKK in R1 (RLRPGGRKK; sub- stitutions are ... See full document
10
Sequence Variation in a Newly Identified HLA-B35-Restricted Epitope in the Influenza A Virus Nucleoprotein Associated with Escape from Cytotoxic T Lymphocytes
... resulting from immune pressure mediated by specific ...for escape from antibody-mediated immunity, further evidence which shows that influenza viruses can escape from CTL-mediated ... See full document
6
Loss of viral fitness and cross recognition by CD8+ T cells limit HCV escape from a protective HLA B27–restricted human immune response
... viral replication (Figure ...viral replication (Figure 3C) and the high degree of conservation at these sites (Figure ...moderate reduction in viral replication (~50% of WT; Figure 3C), ... See full document
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Immunization with a Modified Vaccinia Virus Expressing Simian Immunodeficiency Virus (SIV) Gag-Pol Primes for an Anamnestic Gag-Specific Cytotoxic T-Lymphocyte Response and Is Associated with Reduction of Viremia after SIV Challenge
... significant reduction in plasma viremia was observed in a parallel study evaluating the relative efficacy of MVA recombinants expressing Gag-Pol, Env or a combination of Gag-Pol and Env (40, ... See full document
8
Antiviral Activity of Human Immunodeficiency Virus Type 1 Gag-Specific Cytotoxic T Lymphocyte Targeting Is Not Necessarily Intrinsically Superior to Envelope Targeting
... viral replication (1, 4, ...of 1:4. HIV-1 p24 antigen capture enzyme-linked immunosorbent assays (ELISAs) (PerkinElmer) were performed on medium supernatants at days 3 and 6 after infection to ... See full document
5
High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control
... CTL response and epitope presentation, without taking into consideration several additional factors that are likely important in deter- mining the in vivo efficiency of these ...CTL response independently ... See full document
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