[PDF] Top 20 Role of Conserved Cysteines in the Alphavirus E3 Protein
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Role of Conserved Cysteines in the Alphavirus E3 Protein
... disrupt protein func- tion but rather induced the formation of a disulfide bond between two adjacent Cys residues ...system. Role of the PPCXPCC motif in ...in E3 correlated with infec- tivity of ... See full document
8
Conserved Cysteines of the Human Immunodeficiency Virus Type 1 Protease Are Involved in Regulation of Polyprotein Processing and Viral Maturation of Immature Virions
... reactive cysteines in the HIV-1 protease may be only one of several factors that prevent immature virions from undergoing com- plete maturation following removal of the protease ...a role in altering and/or ... See full document
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Mutating Conserved Cysteines in the Alphavirus E2 Glycoprotein Causes Virus-Specific Assembly Defects
... assembly, E3 plays a chaperone role for E2 folding (6, 40, 43) and the presence of E3 is thought to prevent the spikes from prema- turely converting from the stable conformation to the meta-stable ... See full document
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The Domain I-Domain III Linker Plays an Important Role in the Fusogenic Conformational Change of the Alphavirus Membrane Fusion Protein
... The alphavirus Semliki Forest virus (SFV) infects cells through a low-pH-dependent membrane fusion reaction mediated by the virus fusion protein ...highly conserved histidine (H3) on the E1 ... See full document
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Dissecting the Role of E2 Protein Domains in Alphavirus Pathogenicity
... precise role for both domains A and B in cell ...important role in ...a role in receptor mediated entry (reviewed in reference ...and E3 have been shown to play an important role in ... See full document
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Role of Conserved Histidine Residues in the Low-pH Dependence of the Semliki Forest Virus Fusion Protein
... Based on their sequence conservation and proximity to charged residues in the prefusion and postfusion structures, the alpha- virus E1 residues H125 and H3 were suggested as candidates to control low-pH triggering (18). ... See full document
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Cysteines and N-Glycosylation Sites Conserved among All Alphaherpesviruses Regulate Membrane Fusion in Herpes Simplex Virus 1 Infection
... the role of disulfide bond reduction in the conversion of many viral fusion proteins from a pre- to postfusion conformation is that the probable disulfide linkage between cysteines 82 and 243 of gK acts as a ... See full document
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Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI
... each protein fused with mCherry fluorescent tag, stably transformed into a line expressing a functional VIRprom:GFP-VIR construct ...splicing protein SR34 fused to RFP (Lorkovi c et ...each protein ... See full document
16
Role of Simian Virus 40 Vp1 Cysteines in Virion Infectivity
... the role of cysteine residues in the for- mation of infectious virions by individually mutating the seven cysteines in the major capsid protein, ...strictly conserved cysteine across the ... See full document
6
The Alphavirus E3 Glycoprotein Functions in a Clade-Specific Manner
... of alphavirus particles are required for mediating viral entry into a host ...proteins, E3, E2, 6K and its translational frameshift product TF, and E1. E3 is a small, ⬃65-amino-acid glycoprotein that ... See full document
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Palmitoylation on Conserved and Nonconserved Cysteines of Murine IFITM1 Regulates Its Stability and Anti-Influenza A Virus Activity
... HA-mIFITM1 protein level was observed in cell lysates, while no change in the level of HA-mIFITM1-4C¡A was observed upon zDHHC7 overexpression ...overall protein level is likely due to palmitoylation ... See full document
5
The Role of E3 in pH Protection during Alphavirus Assembly and Exit
... decreases protein secretion (39, 40), and, indeed, viral production from WT-infected cells was decreased ⬃3 logs by ba- filomycin ...the E3 Y47/48A mutations had no detectable effects on virus pH de- ...the ... See full document
8
Characterization of E3/49K, a Novel, Highly Glycosylated E3 Protein of the Epidemic Keratoconjunctivitis-Causing Adenovirus Type 19a
... the E3/49K form with 13 oligosaccharides lacks a glycan at position 343 and that with 12 glycans might in addition be devoid of carbohydrates at position 312 or 317 ...for E3/19K molecules of Ad19a ... See full document
12
Noncapped Alphavirus Genomic RNAs and Their Role during Infection
... Alphaviruses are enveloped positive-sense RNA viruses that exhibit a wide host range consisting of vertebrate and invertebrate species. Previously we have reported that the infectivity of Sindbis virus (SINV), the model ... See full document
13
Regulation of Protein Kinase C function by phosphorylation on conserved and non conserved sites
... While A-loop phosphorylation is required for catalytic activity of most PKC isoforms, a notable exception is PKC (Table 1). Mutation of the A-loop residue of PKC has no effect on in-vitro catalytic activity [30,31,13]. ... See full document
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Genetic Determinants of Sindbis Virus Mosquito Infection Are Associated with a Highly Conserved Alphavirus and Flavivirus Envelope Sequence
... envelope protein to mosquito but not mammalian cells, indicating that this region has more specific- ity for insect cells ...Mut-5-like alphavirus and flavivirus residues align spatially but their sequences ... See full document
9
A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine
... VSV/CHIKV recombinants induce cellular immune re- sponses in C57BL/6 mice. Because VSV-based vaccine vectors are known to be potent inducers of both humoral and cellular im- mune responses (36, 37), we also looked at the ... See full document
8
The conserved role of sirtuins in chromatin regulation
... Sir-2.1 is Type I sirtuin and the sirtuin most closely related to ScSir2p. The fact that Sir-2.1 has a nuclear localization and is phylogenetically close to mammalian SirT1 (Frye, 2000) suggests that it is probably a ... See full document
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Region E3 of subgroup B human adenoviruses encodes a 16-kilodalton membrane protein that may be a distant analog of the E3-6.7K protein of subgroup C adenoviruses.
... the E3 transcription unit of adenovirus type 3 (Ad3) and Ad7 that could encode a protein of 16 kDa (16K ...16K protein is expressed in Ad3- and Ad7-infected cells at early and late stages of ... See full document
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A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis
... of cysteines in the core of this domain had a major effect on aggregation of the ANCL ...of cysteines 8-10 to alanines led to a band-shift in wild-type CSPα, consistent with removal of palmitoylated resi- ... See full document
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