[PDF] Top 20 Role of cyclin E in the pathogenesis of hepatocellular carcinoma
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Role of cyclin E in the pathogenesis of hepatocellular carcinoma
... active cyclin E, miR-34a,c in DNs and early HCCs with congruent loss of p53 function associated with cell cycle checkpoint failure, diminished apoptosis and increased proliferative ...and cyclin ... See full document
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Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance
... Abstract: Hepatocellular carcinoma (HCC) is one of the most common primary hepatic malignancies and one of the fastest-growing causes of cancer-related mortality in the United ...the pathogenesis of ... See full document
13
Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma
... the role of pyroptosis in human hepatocellular carcinoma (HCC) remains largely ...the pathogenesis of ...the pathogenesis of HCC, and may be a new neoplastic target for the treatment of ... See full document
8
Role of microRNAs in hepatocellular carcinoma: a clinical perspective
... injury and regeneration. Increased hepatocyte turnover, inflammation, and oxidative DNA damage are implicated in the pathogenesis of the disease. The prevalent risk factors for HCC are also the cause of liver ... See full document
12
Emerging role of Toll-like receptor 4 in hepatocellular carcinoma
... Although many factors are involved in the pathogenesis and progression of HCC, its underlying mechanisms remain unknown. Recent research demonstrated that Toll- like receptor (TLR)4 expression levels were strongly ... See full document
7
<p>Anisodamine Suppressed the Growth of Hepatocellular Carcinoma Cells, Induced Apoptosis and Regulated the Levels of Inflammatory Factors by Inhibiting NLRP3 Inflammasome Activation</p>
... Chronic in fl ammation plays an important role in the pathogenesis of cancer. The NOD-like receptor family, pyrin domain containing 3 (NLRP3) in fl ammasome is an important in fl ammatory complex discovered in ... See full document
12
<p>Lichen sclerosus: the role of oxidative stress in the pathogenesis of the disease and its possible transformation into carcinoma</p>
... of cyclin-dependent kinase inhibitors that is essential for cell cycle control; p16I INK4 and p27 Kip1 work as negative regulators of the cell cycle (G1 phase) and are considered tumor ... See full document
10
Clinicopathological role of miR-30a-5p in hepatocellular carcinoma tissues and prediction of its function with bioinformatics analysis
... It should be emphasized that limitation exists in this study. First, the survival data are missing due to the fact that most patients were lost after they were discharged from our hospital. The prognostic value of ... See full document
11
Role of Beclin1 expression in patients with hepatocellular carcinoma: a meta-analysis
... Methods: PubMed, Cochrane Library, Web of Science, EMBASE, Chinese CNKI, and Chinese WanFang databases were searched for published articles on Beclin1 expression in hepatocellular tissues. Standard-compliant ... See full document
11
Emerging role of Hpo signaling and YAP in hepatocellular carcinoma
... HCC remains a disease with a poor prognosis, due to the inef- fective therapies for advanced disease. Recent studies have further elucidated the inner workings of the Hpo-signaling cascade and unmasked this critical ... See full document
10
A Study to investigate the role of p27 and Cyclin E immunoexpression as a prognostic factor in early breast carcinoma
... of cyclin E with distant metastases in all invasive carci- nomas, in the IDC group only and in the node negative group when cyclin E was stratified as negative and posi- tive ...of ... See full document
9
The comparison of surgical patients with primary hepatic squamous cell carcinoma or adenosquamous carcinoma and surgical patients with hepatocellular carcinoma
... the pathogenesis. Simi- larly, though some pathogenesis of primary hepatic ASC had been proposed previously, it was still ...The pathogenesis was also believed to be that the chronic inflammation ... See full document
8
The role of external beam radiotherapy for hepatocellular carcinoma patients with lymph node metastasis: a meta-analysis of observational studies
... Our study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We systemically searched the studies from PubMed, Embase, Medline, and Cochrane library published until December 24, 2017. The ... See full document
11
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma
... is involved in chromosome stability and maintains the oscillation attenuation of the mitotic spindle micro- tubule. Therefore, dysfunction of KIF18A can lead to chromosome instability [2 – 7]. Several studies have shown ... See full document
8
<p>Profile of lenvatinib in the treatment of hepatocellular carcinoma: design, development, potential place in therapy and network meta-analysis of hepatitis B and hepatitis C in all Phase III trials</p>
... important role in diverse cell functions, including prolif- eration, differentiation, apoptosis, and migration, and also in tumor proliferation, angiogenesis, migration, and ... See full document
8
<p>Role of OCT1 in hepatocellular carcinoma</p>
... promoter sequence, even in certain introns described in pre- vious reports. However, we still have no complete under- standing about the biological implication of numerous SNPs in the untranslated regions. 32–34 Except ... See full document
10
The role of PHD2 mutations in the pathogenesis of erythrocytosis
... Indeed, many HIF target genes are involved in cell proliferation and survival, such as angiogenesis (vascular endothelial growth factor and platelet derivative growth factor), cell proliferation (transforming growth ... See full document
20
The utility of biomarkers in hepatocellular carcinoma: review of urine-based <sup>1</sup>H-NMR studies – what the clinician needs to know
... compared to blood tests, which can cause discomfort or harm. Greater understanding of this topic offers further insight into disease development, prognosis, and pathogenesis. This is done through achieving ... See full document
12
<p>The Role of Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease</p>
... immune response. Several scienti fi c groups have found that during TCR activation TLR2 signal mediated MyD88- dependent signaling pathway enhances the expression of key Th17 transcription factors activating IL-17 ... See full document
13
<p>Profile of Cabozantinib for the Treatment of Hepatocellular Carcinoma: Patient Selection and Special Considerations</p>
... Abstract: Management of advanced hepatocellular carcinoma is challenging. With an increasing number of options for the fi rst and second-line treatment, understanding and developing optimal systemic ... See full document
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