[PDF] Top 20 The role of heterogeneity in asthma: a structure-to-function perspective

... with frequency [12, 14]. These data do not reflect much detail in the why or where or how they become abnor- mal in diseased states such as asthma. In contrast, lower frequency ranges (<10 Hz) have been found ... See full document

... Fourth, in the absence of heteroskedasticity, the model performance deteriorates con- siderably. Note that we can obtain the homoskedastic version of the model by simply setting the coefficients of the ARCH term (α) and ... See full document

... But these limits are imposed by our Constitution, and they serve an important function. Arbitrary or policy-laden decisions by courts erode our constitutional structure. They foster dependence on judges and ... See full document

... heterogeneous structure with a huge flood of Konkor participants, different ethnic groups, and young population ...geographical heterogeneity have been influential on the scientific system as ... See full document

... the role played by the ECM and cellular receptors, such as integrins, in the differential function and disease association of adipose tissue depots is less well ...complex structure consisting of a ... See full document

... new asthma susceptibity genes that are expressed in the airway epithelium and innate immunity ...sentinel role played by airway epithelium function and innate immunity in asthma promote the ... See full document

... with asthma and serum total IgE ...mRNA structure as our bioinformatics results suggest [45]. The role of Th17 in asthma pathogenesis, however, needs further investiga- tions, as ... See full document

... lung structure and function among ...primitive function with lower surface activity because larger respira- tory units are more compliant and the risk of end-expiratory collapse is far ...alveolar ... See full document

... allelic heterogeneity and different linkage disequilibrium patterns according to different ethnicities, 24 genes previously associated with FEV 1 /FVC with proba- bility values less than ...lung function, ... See full document

... discovered role in mount- ing a type 2 immune response against parasitic helminths, tuft-1 and tuft-2 cells expressed the type 2 cytokine Il25 and the type 2– related cytokine receptors Il17rb, Il4ra, and Il13ra ... See full document

... domain and those containing MORN domains we split the plant MORN repeat sequence database into proteins with or without a PIP5K domain. The general linear model was used to compare each amino acid site using the Amino ... See full document

... quality-adjusted life years (QALY) and £5,238 costs over a lifetime horizon, resulting in an incremental cost-effectiveness ratio of £21,906 per QALY gained (based on 2012 pricing). It was concluded that in adults with ... See full document

... important role in the co- ordination and persistence of inflammation in asthma, although the precise role of each cytokine remains to be determined [ ...and function via cytokine cascade [ ... See full document

... their role in bacterial killing [8], they have been more recently associated with non-infectious disorders like thrombosis, vasculitis, systemic lupus erythematosus, diabetes, cancer, asthma or chronic ... See full document

... with asthma severity including sociodemographic characteristics and several measures of health ...of asthma severity likely provide considerable protection against bias from an unrecognized ...severe ... See full document

... In this paper we developed a model of international trade with oligopol- istic competition to explore the effects of trade liberalization on R&D, firm and industry productivity, production patterns and social ... See full document

... their asthma and mothers’ concerns regarding their children’s asthma were related in the present study, but this correlation was weak (r = ...their asthma than their mothers ...child’s asthma ... See full document

... considered to be multifactorial. The preva- lence of bronchial asthma has increased in worldwide more than 45% since 1970s 4 . In the present days, the prevalence varies considera- bly within countries and between ... See full document

... tant role in these responses, as tissue eosinophilia is a common feature in asthmatic airways, and eosinophils have been demonstrated to cause mucosal injury and likely contribute to the generation of altered lung ... See full document

... Recently developed 133xenon techniques were used in the present investigation of 10 patients whose asthma was "in remission." The aims were to document further the phenomenon of regional[r] ... See full document