[PDF] Top 20 THE ROLE OF P38 MAPK IN CELL CYCLE CHECKPOINT CONTROL FOLLOWING DNA DAMAGE
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THE ROLE OF P38 MAPK IN CELL CYCLE CHECKPOINT CONTROL FOLLOWING DNA DAMAGE
... Dr. Xiang Ye (Oncology Division, Lilly Research Labs, Eli Lilly & Co.) and Prof. Uttam Surana (Institute of Molecular and Cellular Biology, A*STAR & Dept of Pharmacology NUS) for their continuous help, advice and ... See full document
291
Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo
... weeks following crush injury, many small-diameter axons with a thin myelin sheath were observed in both groups, al- though large-diameter axons were coexisting in wt ...physiological role of p38 ... See full document
13
Original Article Renoprotective effect of total glucosides of paeony in STZ-induced diabetic rats: role of thioredoxin-interacting protein
... Protein extraction from the kidneys was per- formed as follows. Kidney samples were ho- mogenized and lysed in Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) sample buffer, boiled, centrifuged, and ... See full document
10
Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes
... significant role for leptin, the product of the obese gene, has been ...of p38 MAPK in cardiac cells and utilization of the p38 MAPK inhibitor, SB203580, demonstrated that this kinase ... See full document
13
Nuclear Localization of p38 MAPK in Response to DNA Damage
... its role in the induction of cell cycle checkpoints in response to DSBs inducing stimuli, little is known about the intracellular distribution of p38 MAPK following its ... See full document
10
Integrin linked kinase regulates p38 MAPK dependent cell cycle arrest in ureteric bud development
... these cell functions on collagen I ...the role for ILK in the regulation of CD cell polarity, cells were grown on transwells until confluent and stained with ZO1 ...two cell lines in ZO1 or ... See full document
11
Hepatitis B Virus X Protein Activates the p38 Mitogen-Activated Protein Kinase Pathway in Dedifferentiated Hepatocytes
... the p38 MAPK plays a physiologically im- portant role in liver, acting as a growth-inhibiting regulator of hepatocyte proliferation during liver development ...high p38 MAPK activity ... See full document
10
Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
... which p38 MAPK can promote survival of tumor cells is by in- hibition of autophagy, such in the case of colon cancer cells ...for cell death other than apopto- sis because it is a mechanism to ... See full document
9
Possible attenuation of the G2 DNA damage cell cycle checkpoint in HeLa cells by extremely low frequency (ELF) electromagnetic fields
... of checkpoint stringency is a feature of oncogenic transformation [14,15]; the gene encoding the p53 tu- mour suppressor that plays such a pivotal role in the G1 DNA damage checkpoint ... See full document
12
Possible attenuation of the G2 DNA damage cell cycle checkpoint in HeLa cells by extremely low frequency (ELF) electromagnetic fields
... of checkpoint stringency is a feature of oncogenic transformation [14,15]; the gene encoding the p53 tu- mour suppressor that plays such a pivotal role in the G1 DNA damage checkpoint ... See full document
11
Cell Cycle Progression in G1 and S Phases Is CCR4 Dependent following Ionizing Radiation or Replication Stress in Saccharomyces cerevisiae
... a role in the repair of S-phase ...mediated checkpoint adaptation on another replication and/or repair system that acts on spontaneous or replication-associ- ated DSBs occurring in S ...for DNA ... See full document
17
BRCA1 tumor suppressor network: focusing on its tail
... the DNA damage response (DDR), to coordinate multiple cellular responses including DNA repair, cell cycle checkpoint regulation, transcription, senescence or apoptosis ...to ... See full document
10
Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control.
... the cell cycle but will also be crucial to under- standing the role of Vpr in HIV-1 replication and in the de- velopment of therapeutic agents to inhibit the activity of ... See full document
8
Anticancer drug targets: cell cycle and checkpoint control
... the cell cycle machinery are frequently altered in human ...of cell cycle ...between cell cycle phases, is controlled by their association with cyclins and cdk inhibitors, by ... See full document
10
DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization
... induced following DNA ...1998), p38 (Bulavin et al., 2003), DNA demethylation (Barreto et ...and p38 together with a marked loss of p38-mediated MK2 activation, only at late ... See full document
16
The Activation of ATR in Response to Double-Stranded DNA Breaks
... with DNA methylation inhibitors 159 ...with DNA polymerase processivity clamp PCNA 111 ...of damage. Caffeine inhibits a damage-independent function of ATM and ATR, which is required for ... See full document
101
The role of Plk4 in DNA damage pathways and entry into mitosis.
... Cdc25C, Cyclin B l nuclear accumulation is also necessary for mitotic entry to occur. Interestingly, evidence indicates that the initial activation of the Cdkl/Cyclin B complex occurs at the centrosome (Jackman et al., ... See full document
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<div>Icotinib hydrochloride enhances chemo- and radiosensitivity by inhibiting EGFR signaling and attenuating RAD51 expression and function in Hela S3 cells</div>
... Notes: raD51 mrna levels at indicated time points after exposure to irradiation (A) or cisplatin (B) were detected using qrT-Pcr. (C and D) raD51 protein levels were examined by Western blotting at indicated time points ... See full document
14
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP
... (ERK) MAPk cascade, but not that of p38 MAPk. A specific p38 MAPk inhibitor (SK&F 86002) blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis ... See full document
13
Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells
... on cell growth, autophagy, and epithelial-to-mesenchymal transition (EMT) and to delineate the possible molecular mechanisms in human pancreatic cancer PANC-1 and BxPC-3 ...potent cell growth inhibitory, ... See full document
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