[PDF] Top 20 Role of the PB2 627 Domain in Influenza A Virus Polymerase Function
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Role of the PB2 627 Domain in Influenza A Virus Polymerase Function
... auxiliary PB2 cap-binding and the PA endonuclease domains are both involved in cap snatching, but the role of the auxiliary PB2 627 domain, implicated in host range restriction of ... See full document
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Conserved Features of the PB2 627 Domain Impact Influenza Virus Polymerase Function and Replication
... the virus through mutation, reassortment of its eight genomic RNA segments, or ...the polymerase plays a key role in regulating this process of cross-species transmission ...The polymerase is ... See full document
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Ubiquitination Upregulates Influenza Virus Polymerase Function
... entire influenza virus life ...proviral role of the ubiqui- tin-proteasome system, showing that all of the proteins in the viral replication machinery are subject to ubiquitination and this is ... See full document
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The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix
... of PB2 with MAVS is not a determinant of its mitochondrial association; PB2 of seasonal hu- man influenza viruses shows the same pattern of mitochondrial localization in MAVS knockout cells as in ... See full document
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Association of the Influenza Virus RNA Polymerase Subunit PB2 with the Host Chaperonin CCT
... the PB2 protein in mammalian ...the PB2 protein but not with the PB1 or PA protein. However, PB2 in association with PB1 or PB1 and PA did not interact with ...that PB2 proteins of different ... See full document
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Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit.
... vaccinia virus encoding T7 RNA ...RNA polymerase activity in vivo by cotransfection with proteins NP, PB1, and PA and a virion-like RNA encoding the cat gene into vaccinia virus T7-infected COS-1 ... See full document
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Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences
... tested influenza A virus poly- merases to inhibition by PB2 1-37 -GFP could be explained by different hypotheses, two of which we discuss here in more ...and PB2 1-37 domains does not play a ... See full document
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Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures
... the polymerase genes are known to play a major role in avian influenza virus adaptation to mammalian ...and PB2, the 2009 pandemic H1N1 virus (pH1N1) can replicate well in ... See full document
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Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans
... RING domain E3 ligases (CRL) that act as protein ...the function of viral proteins, thereby taking part in cellular antiviral response processes that constrain viral infection ... See full document
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Influenza Virus Nucleoprotein Interacts with Influenza Virus Polymerase Proteins
... the function of NP in replication of vRNA remains ...the role of NP in the transcription- to-replication ...the polymerase protein complex from transcription mode to replication ...This ... See full document
9
PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host Cells
... H5N1 influenza viruses has suggested viral mutation as one mechanism for the emergence of novel human influenza A ...the polymerase complex is known to be a key component in host adaptation, ... See full document
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Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals
... The PB2 E627K mutation is known to play a prominent role in the mammalian adaptation of ...the PB2 E627K mutation upon replication in ...low polymerase activity attributed to the viral PA ... See full document
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Mutational and Metal Binding Analysis of the Endonuclease Domain of the Influenza Virus Polymerase PA Subunit
... the PB2 subunit and that the endonuclease activity is situated in the N-terminal domain of the PA subunit ...The influenza endonuclease is a member of the PD-(D/E)XK family of nucleases that use ... See full document
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Structure and Function of the N-Terminal Domain of the Vesicular Stomatitis Virus RNA Polymerase
... viral polymerase, which performs a unique set of reactions to produce genome- and subgenome-length RNA ...the polymerase of vesicular stomatitis virus, a member of the rhabdoviruses, which has served ... See full document
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The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus
... important role in the evolution and host specificity of the influenza A ...different polymerase genes, but the same HA and NA segments, can be used to fur- ther test the hypothesis of viral ... See full document
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Diversity of the RNA Polymerase in the H7N9 Influenza A Virus
... novel influenza virus of the H7N9 subtype has infected more than 350 people in China since 19 February ...the virus is a reassortant originated from H7, N9 and H9N2 avian influenza viruses, ... See full document
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The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon
... pandemic influenza viruses of the 20th cen- tury, only the 1918 “Spanish” influenza virus encodes an as- partic acid at position 9, while the 1957 “Asian” influenza and 1968 “Hong Kong” ... See full document
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Identification of Residues Critical for the Interferon Antagonist Function of Langat Virus NS5 Reveals a Role for the RNA-Dependent RNA Polymerase Domain
... (SH2) domain containing tyrosine phosphatase 1 (SHP-1) and SHP-2, PTP1B/T-cell PTP, and ...NS5’s function as a JAK-STAT antagonist is not itself directly medi- ated by tyrosine ... See full document
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Recognition of Cap Structure by Influenza B Virus RNA Polymerase Is Less Dependent on the Methyl Residue than Recognition by Influenza A Virus Polymerase
... the influenza virus genome has been derived from studies on FluA, while little has been demonstrated for ...the PB2 cap-binding domain of the FluA polymerase with m 7 GTP has been ... See full document
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Association of the Influenza A Virus RNA-Dependent RNA Polymerase with Cellular RNA Polymerase II
... the influenza virus RNA-dependent RNA polymerase is dependent on cellular RNA pro- cessing activities that are known to be associated with cellular RNA polymerase II (Pol II) transcription, ... See full document
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