[PDF] Top 20 Role of prothrombin complex concentrate in perioperative coagulation therapy
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Role of prothrombin complex concentrate in perioperative coagulation therapy
... in perioperative pa- tients without hereditary coagulation disorders has been increasingly reported in anecdotal case series, retrospect- ive, and prospective clinical studies ...severe perioperative ... See full document
9
The role of prothrombin complex concentrates in reversal of target specific anticoagulants
... factor prothrombin complex concentrates have been available for several years in Europe, and recently became available in the United States with approval of ...of prothrombin complex ... See full document
9
Prothrombin complex concentrate in the reduction of blood loss during orthotopic liver transplantation: PROTON-trial
... Patients with end-stage liver disease have an abnormal hemostatic system which is characterized by reduced plasma levels of both pro- and anticoagulant proteins. This results in a hemostatic balance that is more fragile ... See full document
12
Guideline concordant administration of prothrombin complex concentrate and vitamin K is associated with decreased mortality in patients with severe bleeding under vitamin K antagonist treatment (EPAHK study)
... normalize coagulation within one hour (62.2 versus 9.6%; P <0.05) [8]. The role of vitamin K in association with PCC, in maintaining the normalized coagulation over six hours has been emphasized ... See full document
9
Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital
... established role of PCC as preferred treatment for emergency ACR ...of coagulation factors, and there have been no major studies of PCC in bleeding patients without pre-existing coag- ...had ... See full document
7
Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model
... K-dependent coagulation factors [26] and therefore serves not only as a sensitive measure of the effects of anticoagulation therapy, but also of its reversal by PCCs or ...dabigatran therapy in the ... See full document
10
Efficacy of prothrombin complex concentrates for the emergency reversal of dabigatran induced anticoagulation
... concomitant therapy, making the specific impact of PCC/aPCC on dabigatran anticoagulation dif- ficult to ...of coagulation parame- ters or reduction of bleeding ... See full document
15
Fatal Myocardial Infarction Following Therapy with Prothrombin Complex Concentrates in a Young Man with Hemophilia A
... Infusions of prothrombin complex concentrates have been associated with disseminated intravas- cuban coagulation and thromboembolic phenomena in nonhemophiliac patients with liven diseas[r] ... See full document
5
Safety of 4-factor prothrombin complex concentrate (4F-PCC) for emergent reversal of factor Xa inhibitors
... Four-factor prothrombin complex concentrate (4F-PCC), although not FDA approved for factor Xa inhibitor reversal, ap- pears to show the most ...improved coagulation pro- file, decreased blood ... See full document
6
An Exploratory Cohort Study Comparing Prothrombin Complex Concentrate and Fresh Frozen Plasma for the Treatment of Coagulopathy After Complex Cardiac Surgery
... normalized prothrombin time at the time of surgery .... Prothrombin complex concentrates have a smaller volume of administration than FFP for a similar concentration of coagulation factors, ... See full document
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Endogenous thrombin potential following hemostatic therapy with 4 factor prothrombin complex concentrate: a 7 day observational study of trauma patients
... standard coagulation pa- rameters may lead to unnecessary PCC therapy when the true thrombin potential is adequate, potentially increasing the patient’s risk of ...standard coagulation tests for ... See full document
12
Safety and efficacy of prothrombin complex concentrate as first line treatment in bleeding after cardiac surgery
... Since January 2012, PCC has been used systematically as first-line therapy in coagulation management, com- pletely replacing FFP, and this PCC use was consistently followed. Therefore, the PCC study group ... See full document
9
A review of the clinical utility of INR to monitor and guide administration of prothrombin complex concentrate to orally anticoagulated patients
... transfusion therapy and outcome in surgical patients in- cluding trauma ...routine coagulation analysis and also that transfu- sion requirements and need for re-do surgery is lower in patients treated based ... See full document
8
Four-factor prothrombin complex concentrate improves thrombin generation and prothrombin time in patients with bleeding complications related to rivaroxaban: a single-center pilot trial
... and therapy instead of anticoag- ulants such as unfractionated heparin, low molecular weight heparin or vitamin K antagonists, because it is considered to have a wider therapeutic range and a more predictable ... See full document
10
Prothrombin complex concentrate in surgical patients: retrospective evaluation of vitamin K antagonist reversal and treatment of severe bleeding
... anticoagulation therapy are scarce, despite reports dating back more than a decade of their potential and their routine use in massive hemorrhage in many European countries ...severe perioperative or ... See full document
15
Goal directed coagulation management of major trauma patients using thromboelastometry (ROTEM®) guided administration of fibrinogen concentrate and prothrombin complex concentrate
... for coagulation factors in situations of severe bleeding ...reliable coagulation monitoring, and a targeted therapeutic approach according to the test results ...standard coagulation tests (PT and ... See full document
11
Prothrombin complex concentrate versus placebo, no intervention, or other interventions in critically bleeding patients associated with oral anticoagulant administration: a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
... the coagulation cascade over the course of days dependent on especially the weekly warfarin dose and the baseline international normalised ratio [33, ...the coagulation cascade is a function of the ... See full document
13
The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor
... The fact that PCC is widely used as a reversal agent in rivaroxaban-treated patients is partly based on findings in the study performed by Eerenberg et al. [16] where the effect of PCC as an effective reversal agent was ... See full document
8
Comparison of 3-Factor Prothrombin Complex Concentrate and Low-Dose Recombinant Factor VIIa for Warfarin Reversal
... Based on inclusion and exclusion criteria, 74 PCC3 patients and 32 LDrFVIIa patients were included in the final analysis (Figure 1). There were no significant dif- ferences between the groups with regards to age, gender, ... See full document
7
Activated prothrombin complex concentrate factor VIII inhibitor bypassing activity (FEIBA) for the reversal of warfarin-induced coagulopathy
... of coagulation factors VII, IX, X and ...active coagulation factors ...with prothrombin complex concentrate (PCC) and recombinant activated factor VII as alternatives [9, ... See full document
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