[PDF] Top 20 The role of Ras and its downstream targets on cell cycle control
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The role of Ras and its downstream targets on cell cycle control
... T cell activation by phytohaemagglutinin (Reibel et ...serum-induced cell cycle progression from quiescence in Swiss 3T3 cells (Lamarche e ta l, 1996; Olson et ...of Ras in fibroblast ...that ... See full document
266
Cell cycle control of Notch signaling and the functional regionalization of the neuroepithelium during vertebrate neurogenesis
... and cell specification, although miRNA function has lately been related to neuronal plasticity and CNS-related diseases (for reviews, see Kosik, 2006; Fiore et ...a role in neurogenesis (Krichevsky et ... See full document
14
Kinase inhibitors as potential agents in the treatment of multiple myeloma
... stem cell transplantation, these modalities have nearly doubled the disease’s five-year survival rate over the last three decades to about ...the targets and their inhibitors examined are receptor and ... See full document
43
Ras Signaling Gets Fine-Tuned: Regulation of Multiple Pathogenic Traits of Candida albicans
... function downstream of the Ras1/cAMP pathway of ...whereas its overexpression rescues the biofilm defects of the ras1, cyr1, and tpk2 mutants, indicating that Efg1 functions down- stream of these genes to ... See full document
10
Role of β-Catenin and TCF/LEF Family Members in Transcriptional Activity of HIV in Astrocytes
... the cell mem- brane to regulate cellular adhesion or can translocate to the nu- cleus, where it functions as a transcriptional ...by its phosphorylation state, which is regulated by a wide variety of ... See full document
11
Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium
... of cell divisions and cell fate, we demonstrate that: (1) the control of NSC proliferation by Notch primarily targets cell cycle re-entry from quiescence, and thus NSC ... See full document
13
Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species
... apparent role in multiple myeloma has been confound- ...vertebrate cell lines using the multiple myeloma- specific Dis3 mutations indicate they reduce, rather than enhance, cell growth and ... See full document
20
Wild-type N-Ras complements mutant K-Ras in pancreatic cancer cell lines but K-Ras has a specific role in cell cycle independent regulation of G2 cyclins
... important role in cell proliferation and growth as well as cell ...cancer cell lines, I wanted to determine if N-Ras was able to function (independently or with K-Ras) in ... See full document
175
Menin determines K RAS proliferative outputs in endocrine cells
... Despite its dominant role in stimulating growth in the exocrine pancreas (5), our data reveal that K-RAS acts to suppress growth in the pancreatic endocrine cells of the islets of ...divergent ... See full document
10
Anticancer drug targets: cell cycle and checkpoint control
... the cell cycle machinery are frequently altered in human ...of cell cycle ...between cell cycle phases, is controlled by their association with cyclins and cdk inhibitors, by ... See full document
10
Original Article SGK1 protein expression is a prognostic factor of lung adenocarcinoma that regulates cell proliferation and survival
... and downstream bio- logical pathways continue to be expansively explored and elucidated in various cancer mod- els, information about the role of SGK1 as a prognostic factor in human cancers is much more ... See full document
18
Real-time in vivo imaging of p16Ink4agene expression: a new approach to study senescence stress signaling in living animals
... oncogenic Ras or its downstream mediator initiates cellular senes- cence, the state of irreversible cell cycle arrest, through up-regulation of cyclin-dependent kinase (CDK) inhibitors, ... See full document
8
The Role of Intelligence and Locus of Control to Improve the Competence of Employee Individuals
... positive role of intelligence variables in relation to human resource strategies and the performance of knowledge-based innovations can be a source of sustainable benefits because of the knowledge and social ... See full document
5
Role of Baculovirus IE2 and Its RING Finger in Cell Cycle Arrest
... affected cell division, the number of viable SF-21 cells was quantified by staining of the pBs-PstN- or pBs-transfected cells with ...the control pBs-transfected culture had increased more than fourfold, ... See full document
9
The control of cell motility and differentiation by Ras pathways
... The CMF receptor has not been identified although several lines of evidence suggest that is closely linked to the cAMP receptor cARl, probably by a G-protein linked mechanism. Firstly, some of the intracellular responses ... See full document
220
The neurotensin gene is a downstream target for Ras activation
... eukaryotic cell types. Stable transfection of Ha-ras into the human colon cancer line CaCo2 results in the morphologic differentiation to a small bowel ...the Ras regulatory pathway plays a ... See full document
10
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2
... as cell cycle regulation, cell proliferation, apoptosis, differentiation, and survival, in part through promoting the degradation of its substrate proteins [2, ...important role in ... See full document
7
Tocotrienol-rich mixture inhibits cell proliferation and induces apoptosis via down-regulation of the Notch-1/NF-κB pathways in NSCLC cells
... Notes: A549 (A) and H520 (B) cells were seeded treated seeded into Matrigel-coated inserts with TRMC or DMSO. Cells that invaded the lower surface of the insert over a period of 20 hours were stained with crystal violet ... See full document
12
DNA methylation and its role in the trophoblast cell lineage
... the role of DNA methylation in the embryonic cell lineage, the role in the trophoblast lineage has not been explored ...essential role of DNA methylation in the normal development and function ... See full document
9
Effects of different environmental factors on...
... life cycle stages of flies in the sample 2 was completed in 20 days from larviposition to emergence of adult fly at the average temperature ranging from ... See full document
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