[PDF] Top 20 Role of the C terminal domain in the structure and function of tetrameric sodium channels
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Role of the C terminal domain in the structure and function of tetrameric sodium channels
... bundle structure (Supplementary Figs S3 and S4a), suggested that the agreement was good for A221C at the base of the pore and for D250C, A260C and R268C in the coiled-coil, confirming the expected square ...the ... See full document
11
The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes
... cartilage structure leading to a significant reduced body ...the role of the CTD in chondrocyte function and cartilage ...the role of CTD in chondrocyte matrix ... See full document
13
The structure function of the death domain of human IRAK-M
... dosome structure (Figure ...intermediate domain that ex- tends immediately from the DD’s of MyD88 and IRAK-1 are extremely important for function ...the C-terminal domain of ... See full document
19
Investigating Adenovirus E1A as an RNA Polymerase II C-Terminal Domain Mimic and its Role in Transcription Activation
... their structure. E4orf3 may function to inhibit the DNA damage response and play a role in viral replication (Carvalho et ...can function in conjunction with E1B to inhibit p53 and the MRN ... See full document
138
Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1
... essential role in viral transcription, nuclear export of intronless RNAs, translation of viral transcripts, and virion host shutoff ...central role in viral replication and infection, very little is known ... See full document
12
A Single Amino Acid Residue Constitutes the Third Dimerization Domain Essential for the Assembly and Function of the Tetrameric Polycystin-2 (TRPP2) Channel
... undergo C-terminal dimerization (PC2– 4M) were still able to form ER- based Ca 2 ⫹ release channels and could partially rescue the LR defect seen in zebrafish embryos though not the cystic pro- ... See full document
8
Salt, sodium channels, and SGK1
... its role in Liddle’s syndrome, Nedd4-2 is a Hect domain–containing ubiquitin ligase that interacts with the C-terminal tail of ENaC subunits and ubiquitinylates a set of N-terminal ... See full document
5
Differential lipid dependence of the function of bacterial sodium channels
... Full-length sodium channels from ...partially C-terminal truncated channel from ...NavSp channels migrated in SDS denaturing gels at positions corre- sponding to slightly smaller than ... See full document
11
Structure-function relation of the NH2-terminal domain of the Semliki Forest virus capsid protein.
... by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) after being extracted by immunoprecipitation with a monoclonal anti-C antibody (36-1-9 [13]), polyclonal anti-C antiserum ... See full document
8
Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels
... human channels, notably at the beginning of the transmem- brane S3 helix in all domains of all nine human iso- ...functional role for the ...human sodium channels, they are all associated with ... See full document
11
Characterization of the C-terminal binding domain from bacterial Enzyme I
... the role of structural heterogeneity and conformational disorder in regulation of the C-terminal substrate binding domain (EIC) of bacterial Enzyme I ...between structure, ... See full document
89
Structure of the C terminal domain of the Prokaryotic Sodium Channel Orthologue NsvBa
... helical structure, mostly likely a ...a role in stabilising the tetrameric channels, but such a structure is not found (or necessary) in eukaryotic Navs, which are formed of single ... See full document
23
The emerging role of voltage gated sodium channels in tumor biology
... transmembrane domain linking the extracellular N-terminus and the intracellular ...protein domain with a secretory ...pore structure of the channel, but changes the gating, voltage dependence, and ... See full document
8
Structure and function of the β subunit of voltage-gated Ca2+ channels
... Fig. 1. VGCC topology and the structure of the Ca v β core in complex with the AID. (A) Schematic representation of the predicted transmembrane topology of the α 1 subunit of VGCC. The AID, marked in red, is ... See full document
11
Terminal regions confer plasticity to the tetrameric assembly of human HspB2 and HspB3
... that C-terminal sequences are known to mediate assembly in other sHsps, and that residues downstream of the IXI/V motifs in HspB1, B4 and B5 are highly flexible [48–51], whereas the HspB3 sequence ... See full document
15
Terminal regions confer plasticity to the tetrameric assembly of human HspB2 and HspB3
... and C ( ...region C-terminal to β9 strand ( Fig. 1 c) docked into partner ACD β4/β8 ...the C-terminal region of human HspB2 binds to the β4/β8 pockets of human HspB5 ACD dimer ... See full document
14
The C-Terminal Domain of ERp29 Mediates Polyomavirus Binding, Unfolding, and Infection
... The ERp29 helix ␣ 9 mutants bind less efficiently to PyV than WT ERp29. The helix ␣ 9 ERp29 mutants failed to pro- mote unfolding of the PyV VP1 or to stimulate infection. As these mutants dimerize and do not appear to ... See full document
9
NMR structure of C-terminally tagged gramicidin channels
... All experiments were conducted without spinning the sample. All spectra were recorded at 55³C in order to give narrower linewidths and to compare results with previous data for gA and its analogues [8]. Phase- ... See full document
9
Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity
... unique C-termi- nal 41 or 61 ...the role of the C-terminal unique region in shutoff ...PA-X C-terminal deletion mutants, we found that the first 9 amino acids were sufficient for ... See full document
11
Role of the C terminal domain of the HIV 1 glycoprotein in cell to cell viral transmission between T lymphocytes
... Env-CT domain has also been shown to impact intracellular local- isation of Gag and the subcellular localisation of particle ...Env-CT domain and in particular a membrane-proximal tyrosine-based signal ... See full document
11
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