[PDF] Top 20 Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes.
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Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes.
... A low infectious dose approximately 0.05 infectious unit per cell of vif-positive and vif-negative virus stock produced in either SupTl, C8166, Jurkat, or CEM cells was used to initiate [r] ... See full document
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Phosphatidylinositol 3-Kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages
... In the case of HIV-1, only viruses competent to induce signaling through the CCR5 coreceptor are able to establish productive infection within macrophages (4). Primary viral iso- lates and laboratory-adapted ... See full document
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Efficient Replication of Human Immunodeficiency Virus Type 1 in Resting CD4+ T Lymphocytes Is Induced by Coculture with Autologous Dendritic Cells in the Absence of Foreign Antigens
... a virus-specific immune response since they are recognized as the most potent antigen-presenting cells of the immune system, yet they also play a pivotal role in establishment and dissemination of hu- man ... See full document
5
Association of Human Immunodeficiency Virus Type 1 Vif with RNA and Its Role in Reverse Transcription
... modulate virus infectiv- ity. Vif is a lentiviral protein which modulates viral replication (22, 23, 39) and, consequently, pathogenicity ...of virus assembly by enabling the establishment of ... See full document
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Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary CD4+ T Lymphocytes, Monocytes, and Dendritic Cells by Cytotoxic T Lymphocytes
... Besides lymphocytes, other CD4-expressing cells are thought to be infected in ...the replication of monocyte-tropic (M-tropic, R5) strains of HIV-1 in ...of virus in vivo that may decay ... See full document
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Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytes.
... The Vif protein of human immunodeficiency virus type 1 (HIV-1) determines HIV-1 infectivity as a function of the cell type producing the virus (7, 8, ... See full document
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Role of Vif in Stability of the Human Immunodeficiency Virus Type 1 Core
... Most replication-defective gag mutants exhibit altered core morphology with round rather than cone-shaped cores (16, 21, 31, ...and vif mutant virions. It has been suggested that maturation of the ... See full document
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Plasma Membrane-Targeted Raf Kinase Activates NF-κB and Human Immunodeficiency Virus Type 1 Replication in T Lymphocytes
... in the ATP-binding site of Raf, which abolishes kinase activity (kinase-dead mutants [KD]). HA-tagged Raf-C4 is a dominant negative carboxy-terminal deletion mutant of Raf-1 and contains the Ras-binding domain ... See full document
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Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction between Vif and ElonginC
... on virus replication in different types of human T cell lines in a spreading infection assay ...or Vif-deficient virus NL4-3 ⌬ Vif was used to infect non- permissive (CEM ... See full document
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Partial Activation and Induction of Apoptosis in CD4+ and CD8+ T Lymphocytes by Conformationally Authentic Noninfectious Human Immunodeficiency Virus Type 1
... HIV-1 virus was replicating in the freshly isolated PBMC cells by measuring the levels of HIV strong-stop, gag, and 2-LTR circle DNA present in the cells by quantitative real-time PCR ...HIV ... See full document
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Human Immunodeficiency Virus Type 1 (HIV-1)-Induced GRO-α Production Stimulates HIV-1 Replication in Macrophages and T Lymphocytes
... and lymphocytes (C and D) were gated according to forward and side scatter and, in some experiments, by the presence of CD4 or ...and lymphocytes, n ⫽ 6 ... See full document
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Dendritic Cells Preferentially Transfer CXCR4-Using Human Immunodeficiency Virus Type 1 Variants to CD4+ T Lymphocytes in trans
... Human immunodeficiency virus type 1 (HIV-1) preferentially utilizes the CCR5 coreceptor for target cell entry in the acute phase of infection, while later in disease progression ... See full document
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Intracellular expression of RNA transcripts complementary to the human immunodeficiency virus type 1 gag gene inhibits viral replication in human CD4+ lymphocytes.
... FIG. 1. Structure and expression of retroviral vector carrying the antisense C-gag fragment. (A) Detailed map of the HIV-1 genome corresponding to the C-gag sequence. 59 SD, 59 splice donor site of the ... See full document
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Human Immunodeficiency Virus Type 1-Associated CD40 Ligand Transactivates B Lymphocytes and Promotes Infection of CD4+ T Cells
... and human lymphoid tissue cultured ex vivo (44), there is no information regarding the molecular mecha- nism responsible for the insertion of this cell surface molecule within viruses or on the potential ... See full document
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Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes.
... the 1-week coculture, transient transfec- tions, and in vitro transcription experiments were stimulated with mitogen to increase cell numbers and viral transcription as previously described for assays with ... See full document
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CXCR4-Dependent Infection of CD8+, but Not CD4+, Lymphocytes by a Primary Human Immunodeficiency Virus Type 1 Isolate
... ing CD4 molecules ...primary T cells, as discussed above, expression of CCR5 is limited to a very small fraction of the CD4 ⫹ T ...lated CD4 ⫹ cells, further affecting infection by the ... See full document
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Nef-Mediated Resistance of Human Immunodeficiency Virus Type 1 to Antiviral Cytotoxic T Lymphocytes
... it virus spe- cific through the direct interaction of the hybrid receptor with gp120 on the surface of infected cells, bypassing the need for antigen processing ...nef-deleted virus, in contrast to ... See full document
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Human Endothelial Cells Enhance Human Immunodeficiency Virus Type 1 Replication in CD4+ T Cells in a Nef-Dependent Manner In Vitro and In Vivo
... circulating lymphocytes within the microvasculature, especially within capillaries and venules ...memory T cells, resulting in proliferation and cytokine elaboration (28, 31, ...Cultured human ECs, ... See full document
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An Antigenic Threshold for Maintaining Human Immunodeficiency Virus Type 1-specific Cytotoxic T Lymphocytes
... CD8 T cell-mediated immunity plays a piv- otal role in controlling retroviral infections in vivo ...in human subjects, we examined the number of CTL in two groups of patients whose viremia levels ... See full document
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Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.
... proteins, virus- specific CTL are thought to inhibit virus replication by lysing infected cells before infectious virions can be ...of virus produced by HIV-1-infected cells before be- ... See full document
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