[PDF] Top 20 Kaposi's Sarcoma-Associated Herpesvirus K8 Is an RNA Binding Protein That Regulates Viral DNA Replication in Coordination with a Noncoding RNA
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Kaposi's Sarcoma-Associated Herpesvirus K8 Is an RNA Binding Protein That Regulates Viral DNA Replication in Coordination with a Noncoding RNA
... of K8 in coordination with T1.4 RNA in regulating KSHV DNA replication during de novo ...as noncoding regions is actu- ally transcribed and gives rise to stable ...of ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus mRNA Accumulation in Nuclear Foci Is Influenced by Viral DNA Replication and Viral Noncoding Polyadenylated Nuclear RNA
... Quantification of FISH and IF images. Image analysis was performed with ImageJ on an assembled stack of the different fluorescent stains and the merged image. Measurements were first scaled according to the scale bar ... See full document
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Interplay between Polyadenylate-Binding Protein 1 and Kaposi's Sarcoma-Associated Herpesvirus ORF57 in Accumulation of Polyadenylated Nuclear RNA, a Viral Long Noncoding RNA
... PAN RNA re- mains ...performed RNA pulldown assays using a PAN RNA oligomer, oJM35, that covers the MRE 9-nt core region in MRE stem-loop II FIG 2 KSHV ORF57 interacts with ...PABPC1 protein ... See full document
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The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus
... transcriptome-wide binding profile of SND1 to cellular and KSHV mRNAs, revealing SND1 as a bona fide RNA-binding protein that targets m 6 A-modified RNAs in KSHV-infected cells, including the ... See full document
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The tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus
... transcriptome-wide binding profile of SND1 to cellular and KSHV mRNAs, revealing SND1 as a bona fide RNA-binding protein that targets m 6 A-modified RNAs in KSHV-infected cells, including the ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus ORF68 Is a DNA Binding Protein Required for Viral Genome Cleavage and Packaging
... Herpesviral DNA packaging into nascent capsids requires multiple con- served viral proteins that coordinate genome ...ORF68 protein of Kaposi’s sarcoma-associated herpesvirus ... See full document
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A Mobile Functional Region of Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein Independently Regulates DNA Binding and Protein Abundance
... of DNA binding by p53 the C-terminal basic region allows p53 to search DNA for its spe- cific response elements that are ultimately bound in a se- quence-specific ...of viral lytic cycle ... See full document
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Autoregulation of DNA Binding and Protein Stability of Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein
... Kaposi’s sarcoma-associated herpesvirus (KSHV) initiates the viral lytic ...ORF50 protein activates downstream KSHV target genes by at least two mechanisms: direct recognition of ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Hijacks RNA Polymerase II To Create a Viral Transcriptional Factory
... efficient binding to DNA templates, facilitating RNA polymerase II recruitment and frequent reutilization of stable preinitiation ...effective viral transcription by focal assembly of ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Lytic Origin (ori-Lyt)-Dependent DNA Replication: Identification of the ori-Lyt and Association of K8 bZip Protein with the Origin
... ori-Lyt’s. K8 protein ap- pears to need the entire identical duplicated region for stable ...the binding of K8 to the ori-Lyt DNA is only stable when the whole replication ... See full document
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CTCF Regulates Kaposi's Sarcoma-Associated Herpesvirus Latency Transcription by Nucleosome Displacement and RNA Polymerase Programming
... CTCF binding to a cluster of three sites in the first intron of the KSHV major latency ...in viral gene expression, mRNA pro- cessing, RNAPII enrichment, RNAPII-accessory factor interac- tions, histone ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication
... default replication mode of ...lytic replication is primarily controlled at the viral chromatin level through histone and DNA modifica- tions ...given viral transcript when KSHV-infected ... See full document
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RNA Binding Protein RBM38 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19, Which Facilitates Viral DNA Replication
... B19V DNA replication and virion release through the regulation of 11-kDa protein ...decreases viral DNA replication and virion release via reduction of 11-kDa protein ... See full document
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Expression of the Antisense-to-Latency Transcript Long Noncoding RNA in Kaposi's Sarcoma-Associated Herpesvirus
... of noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and lncRNAs, which have been shown to exert critical regulatory functions without coding for recognizable ...key viral lncRNA, ALT, by physically ... See full document
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The K1 Protein of Kaposi's Sarcoma-Associated Herpesvirus Augments Viral Lytic Replication
... reported that the expression of lytic cycle genes was diminished up to 80% in the presence of a K1 dominant negative mutant, which inhibited wild-type K1 signal transduction in BCBL-1 cells that were induced into ... See full document
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The Kaposi's Sarcoma-Associated Herpesvirus K8 Protein Interacts with CREB-Binding Protein (CBP) and Represses CBP-Mediated Transcription
... 3. K8 represses the transcription of AP-1 in a CBP-dependent ...and K8 expression plasmids CMV2N3T K8, K8(190–237), and ...by K8 in a dose-dependent manner, but does not activate the ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus ori-Lyt-Dependent DNA Replication: cis-Acting Requirements for Replication and ori-Lyt-Associated RNA Transcription
... The goal of this study was to understand the structure and function of KSHV ori-Lyt and identify cis-acting elements that are essential for origin function. A systematic mutational anal- ysis was performed on the core ... See full document
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RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication.
... The hepatitis B virus capsid or core protein (p21.5) binds nucleic acid through a carboxy-terminal protamine region that contains nucleic acid-binding motifs organized into four repeats [r] ... See full document
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Specific Binding of Tombusvirus Replication Protein p33 to an Internal Replication Element in the Viral RNA Is Essential for Replication
... genome replication in plus-strand RNA viruses is poorly under- ...replicase protein binds specifically to an internal replication element (IRE) located within the p92 RNA- dependent ... See full document
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RNA-binding protein CPEB1 remodels host and viral RNA landscapes.
... decreasing protein levels through frameshifts and nonsense mediated decay, either of which can change the cellular environment to support viral ...the associated proliferation ... See full document
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