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A screen for modifiers of Deformed function in Drosophila.
... Identification of mutations at known loci: We used two methods to test whether the mutants isolated from our screen corresponded to previously identified loci: embryonic cutic[r] ... See full document
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A Screen for Dominant Modifiers of the irreC-rst Cell Death Phenotype in the Developing Drosophila Retina
... the Drosophila retina requires activity of the irregular chiasmC-roughest (irreC-rst) ...genetic screen for dominant enhancers and suppressors of the adult rough eye ...dominant modifiers that ... See full document
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A Screen for Modifiers of Cyclin E Function in Drosophila melanogaster Identifies Cdk2 Mutations, Revealing the Insignificance of Putative Phosphorylation Sites in Cdk2
... in Drosophila melanogaster for mutations that act as dominant modifiers of an eye phenotype caused by a Sevenless-CycE transgene that directs ectopic Cyclin E expression in postmitotic cells of eye imaginal ... See full document
12
A Genetic Screen for Modifiers of E2F in Drosophila melanogaster
... pathway is mutated in most forms of cancer, suggesting that the deregulation of E2F, and hence the cell cycle, is a common event in tumorigenesis. Extragenic mutations that enhance or suppress E2F activity are likely to ... See full document
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Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila
... Results: To systematically identify novel components of the PD pathways, we generated a genetic background that allowed us to perform a genome-wide F1 screen for modifiers of Drosophila parkin (park) ... See full document
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A Genetic Screen for Modifiers of a Kinase Suppressor of Ras-Dependent Rough Eye Phenotype in Drosophila
... to function downstream of RAS in multiple receptor tyrosine kinase (RTK) ...molecular function of KSR remains ...KSR function, we conducted a dominant modifier screen in Drosophila ... See full document
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A Genetic Screen for Dominant Modifiers of a Small-Wing Phenotype in Drosophila melanogaster Identifies Proteins Involved in Splicing and Translation
... catalytic function in the spliceosome of all ...The function of this domain is unclear, but it is also found in proteasome regulatory subunits, eIF-3 subunits, F igure ... See full document
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A Genetic Screen for Modifiers of Drosophila Src42A Identifies Mutations in Egfr, rolled and a Novel Signaling Gene
... Drosophila Src42A, a close relative of the vertebrate c-Src, has been implicated in the Ras-Mapk signaling cascade. An allele of Src42A, Su(Raf )1, dominantly suppresses the lethality of partial ... See full document
15
A Genetic Screen for Dominant Modifiers of a cyclin E Hypomorphic Mutation Identifies Novel Regulators of S-Phase Entry in Drosophila
... our screen, binds to the planar polarity regulate the Wg-Arm pathway (Katoh ...in Drosophila, it would provide another ...junction function and the Egfr tions between Zn72D and Actin 5C, a component ... See full document
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A Genetic Screen of the Drosophila X Chromosome for Mutations That Modify Deformed Function
... of Drosophila encode tran- ment of Hox specification in the many disparate develop- scriptional regulators that bind DNA through a 60- mental pathways required to pattern a metameric ani- amino-acid homeodomain ... See full document
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A Screen for Dominant Modifiers of roDom, a Mutation That Disrupts Morphogenetic Furrow Progression in Drosophila, Identifies Groucho and Hairless as Regulators of atonal Expression
... in Drosophila provides a striking example of an intricate similarity to members of the Achaete-Scute complex (Jar- pattern of diverse cell fates that is achieved in a short man et ...ato function is ... See full document
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A Screen for Modifiers of decapentaplegic Mutant Phenotypes Identifies lilliputian, the Only Member of the Fragile-X/Burkitt's Lymphoma Family of Transcription Factors in Drosophila melanogaster
... genetic screen for new dpp signaling pathway components. The screen exploited a transvection-dependent dpp phenotype: heldout ...The screen generated 30 mutations that appear to disrupt transvection ... See full document
10
A Green Fluorescent Protein Reporter Genetic Screen That Identifies Modifiers of Hox Gene Function in the Drosophila Embryo
... genetic screen designed to identify functions required for the control of the wingless (wg) and empty spiracles (ems) target genes by the Hox Abdominal-A and Abdominal-B ... See full document
14
Identification of Chromosome Inheritance Modifiers in Drosophila melanogaster
... recovered that significantly increased J21A transmission, A sensitized P-element screen to identify dominant ranging from 38% to as high as 51% (completely stable) mutations that affect chromosome inheritance: The ... See full document
15
Identification of Trans-dominant Modifiers of Prat Expression in Drosophila melanogaster
... a screen for ethyl methanesulfonate (EMS)-induced are divergently transcribed and partly transcriptionally mutations in region 84E1-2, five Prat alleles that had a controlled by nuclear respiratory factor 1, which ... See full document
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Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson’s Disease
... initial screen, we pursued the top association candidates and neuron projection candidates (25 genes total) to test their ability to influence the LRRK2 G2019S locomotor ... See full document
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Drosophila melanogaster as a model organism for Alzheimer’s disease
... genome-wide screen for modifiers of Aβ42-induced neurodegeneration ...performed screen, we tested RNAi lines targeting corresponding Drosophila orthologs of known susceptibility genes identi- ... See full document
12
The Basis of VCP-Mediated Degeneration: Insights From a Drosophila Model of Disease
... a Drosophila model of disease that recapitulated VCP mutation-dependent ...its function. The three remaining dominant modifiers identified were all RNA-binding proteins including TBPH, the ... See full document
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The Lighten up (Lip) gene of Drosophila melanogaster, a modifier of retroelement expression, position effect variegation and white locus insertion alleles.
... The Lighten up (Lip) gene in Drosophila melanogasterwas identified in a mutagenic screen to detect dominant second site modifiers of white-blood (w"), a retrotran[r] ... See full document
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Genetic Modifiers of Tauopathy in Drosophila
... Both modifiers enhanced the loss of eye pigmenta- tion and induced necrotic black dots (Figure 3C, ...a Drosophila homolog of ...modifier screen, previous Drosophila genetic screens for ... See full document
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